The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning

Posted by dbos UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Yan-Feng Zhang, Jean-Philippe Dufour, Peter Zatka-Haas, Peter Redgrave, Melony J Black, Armin Lak, Ed Mann, Stephanie J Cragg, Wickliffe Abraham and John NJ Reynolds | Summary: In classical Pavlovian conditioning, it is well-established that midbrain dopamine neurons respond to conditioned stimuli (CS) that predict a reward. However, how the […]


Continue.. The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning

Targeted stimulation of motor cortex neural ensembles drives learned movements

Posted by dbos UCSD / Salk

Kavli Affiliate: Takaki Komiyama | Authors: An Wu, Qiyu Chen, Bin Yu, Soyoung Chae, Zijing Tan, Assaf Ramot and Takaki Komiyama | Summary: During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated whether M1 […]


Continue.. Targeted stimulation of motor cortex neural ensembles drives learned movements

C. elegans LET-381/FoxF and DMD-4/DMRT control development of the mesodermal HMC endothelial cell

Posted by dbos Rockefeller

Kavli Affiliate: Shai Shaham | Authors: Nikolaos Stefanakis, Jasmine Xi, Jessica Jiang and Shai Shaham | Summary: Endothelial cells form the inner layer of blood vessels and play key roles in circulatory system development and function. A variety of endothelial cell types have been described through gene expression and transcriptome studies; nonetheless, the transcriptional programs […]


Continue.. C. elegans LET-381/FoxF and DMD-4/DMRT control development of the mesodermal HMC endothelial cell

Pathological microcircuits initiate epileptiform events in patient hippocampal slices

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Matthew Elliott, John P. Andrews, Tjitse van der Molen, Jinghui Geng, Alex Spaeth, Anna Toledo, Kateryna Voitiuk, Cordero Core, Thomas Gillespie, Ari Sinervo, David F. Parks, Ash Robbins, Daniel Solis, Edward F. Chang, Tomasz J Nowakowski, Mircea Teodorescu, David Haussler and Tal Sharf | Summary: How seizures begin at […]


Continue.. Pathological microcircuits initiate epileptiform events in patient hippocampal slices

Navigating the Maze: Identifying Potential Pitfalls in Attention State Classification from fMRI Brain Patterns

Posted by dbos Hopkins

Kavli Affiliate: David Linden | Authors: Ruben Andreas Bressler, Assunta Ciarlo, Sophie Raible, Giancarlo Valente, Michael Lührs, Ralph Tier, David E Linden and Rainer Goebel | Summary: Multi-voxel pattern analysis (MVPA) is a powerful technique to decode brain states from functional magnetic resonance imaging (fMRI) activity patterns. In neurofeedback (NF) applications, it has been used […]


Continue.. Navigating the Maze: Identifying Potential Pitfalls in Attention State Classification from fMRI Brain Patterns

Gene regulatory networks and essential transcription factors for de novo originated genes

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Bing-Jun Wang, Nicolas Svetec and Li Zhao | Summary: The regulation of gene expression is crucial for the functional integration of evolutionarily young genes, particularly those that emerge de novo. However, the regulatory programs governing the expression of de novo genes remain unknown. To address this, we […]


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A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping.

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B Kennedy | Summary: Long-term potentiation (LTP) is a biochemical process that underlies learning in excitatory glutamatergic synapses in the Central Nervous System (CNS). The critical early driver of LTP is autophosphorylation of the abundant postsynaptic enzyme, […]


Continue.. A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping.

Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds – Copy

Posted by dbos Rockefeller

Kavli Affiliate: Roderick MacKinnon | Authors: Venkata Shiva Mandala and Roderick MacKinnon | Summary: Gating in voltage-dependent ion channels is regulated by the transmembrane voltage. This form of regulation is enabled by voltage sensing domains (VSDs) that respond to transmembrane voltage differences by changing their conformation and exerting force on the pore to open or […]


Continue.. Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds – Copy

Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds

Posted by dbos UCSF

Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Greg D Field, Michael P Stryker and Steven W Zucker | Summary: A challenge in sensory neuroscience is understanding how populations of neurons operate in concert to represent diverse stimuli. To meet this challenge, we have created “encoding manifolds” that reveal the overall responses of brain areas […]


Continue.. Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds

Image Processing in the Acute to Chronic Pain Signatures (A2CPS) Project

Posted by dbos Hopkins

Kavli Affiliate: Brian Caffo | Authors: Patrick Sadil, Konstantinos Arfanakis, Enamul Hoque Bhuiyan, Brian Caffo, Vince D Calhoun, Daniel J Clauw, Mark C DeLano, James C Ford, Ramtalik Gattu, Xiaodong Guo, Richard E Harris, Eric Ichesco, Micah A Johnson, Heejung Jung, Ari B Kahn, Chelsea M Kaplan, Nondas Leloudas, Martin A Lindquist, Qingfei Luo, Todd […]


Continue.. Image Processing in the Acute to Chronic Pain Signatures (A2CPS) Project