Neural Mechanisms Linking Global Maps to First-Person Perspectives

Kavli Affiliate: Douglas Nitz | Authors: Hin Wai Lui, Elizabeth R. Chrastil, Douglas A. Nitz and Jeffrey L. Krichmar | Summary: Humans and many animals possess the remarkable ability to navigate environments by seamlessly switching between first-person perspectives (FPP) and global map perspectives (GMP). However, the neural mechanisms that underlie this transformation remain poorly understood. […]


Continue.. Neural Mechanisms Linking Global Maps to First-Person Perspectives

Effective Multiple Scattering Correction for Accurate Quantitative OCT

Kavli Affiliate: Xingde Li | Authors: Cheng-Yu Lee and Xingde Li | Summary: We present an effective approach to compensate for multiple scattering effects in Quantitative Optical Coherence Tomography (qOCT) imaging, with the goal of accurately extracting tissue attenuation coefficients, which is crucial for precise clinical diagnosis. In clinical practice, especially for intra-operative imaging, an […]


Continue.. Effective Multiple Scattering Correction for Accurate Quantitative OCT

Topographically organized dorsal raphe activity modulates forebrain sensory-motor computations and adaptive behaviors.

Kavli Affiliate: Emre Yaksi | Authors: Aytac Kadir Mutlu, Bram Serneels, Christoph Wiest, Anh-Tuan Trinh, Ricarda Bardenhewer, Fabrizio Palumbo, Oda Bjornevik Frisvold, Inger Kristine Fjeldskaar Aukrus, Anna Maria Ostenrath and Emre Yaksi | Summary: The dorsal raphe nucleus (DRN) plays an important role in shaping a wide range of behaviors, including mood, motivation, appetite, sleep, […]


Continue.. Topographically organized dorsal raphe activity modulates forebrain sensory-motor computations and adaptive behaviors.

Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders

Kavli Affiliate: Michael Miller | Authors: Zinan Zhou, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, Kisong Kim, Mingyun Bae, Diane D Shao, Bezawit Sahile, Michael B Miller, August Yue Huang, Peter J Park, Clotilde Lagier-Tourenne, Eunjung Alice Lee and Christopher A Walsh | Summary: Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s […]


Continue.. Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders

Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

Kavli Affiliate: Michael Miller | Authors: Guanlan Dong, Chanthia C Ma, Shulin Mao, Samuel M Naik, Katherine Sun-Mi Brown, Gannon A McDonough, Junho Kim, Samantha L Kirkham, Jonathan Cherry, Madeline Uretsky, Elizabeth Spurlock, Ann McKee, August Yue Huang, Michael B Miller, Eunjung Alice Lee and Christopher A Walsh | Summary: Chronic traumatic encephalopathy (CTE) is […]


Continue.. Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

Effectiveness of Digital Dispersion Compensation in OCT

Kavli Affiliate: Xingde Li | Authors: Fengquan Liu and Xingde Li | Summary: Dispersion mismatch in optical coherence tomography (OCT) is typically addressed through either physical or digital compensation. In this study, we investigate the impact of dispersion on OCT detection sensitivity and compare the effectiveness of physical and digital compensation across varying degrees of […]


Continue.. Effectiveness of Digital Dispersion Compensation in OCT

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

Kavli Affiliate: Alexandra Nelson and Anatol Kreitzer | Authors: Katerina L Rademacher, Zak Doric, Dominik Haddad, Aphroditi Mamaligas, Szu-Chi Liao, Rose Creed, Kohei Kano, Zac Chatterton, Yuhong Fu, Joseph H Garcia, Victoria Vance, Yoshitaka Sei, Anatol Kreitzer, Glenda Halliday, Alexandra Nelson, Elyssa Margolis and Ken L Nakamura | Summary: Parkinson’s disease (PD) is characterized by […]


Continue.. Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

Differential glutamatergic and GABAergic responses drive divergent prefrontal cortex neural outcomes to low and high frequency stimulation

Kavli Affiliate: Jyoti Mishra and Dhakshin Ramanathan | Authors: Morteza Salimi, Milad Nazari, Jonathan Mishler, Mishra Jyoti and Dhakshin Ramanathan | Summary: Background Repetitive brain stimulation is hypothesized to bidirectionally modulate excitability, with low-frequency trains decreasing and high-frequency (>5 Hz) trains increasing activity. Most insights on the neuroplastic effects of repetitive stimulation protocols stem from […]


Continue.. Differential glutamatergic and GABAergic responses drive divergent prefrontal cortex neural outcomes to low and high frequency stimulation

Neural representation of action symbols in primate frontal cortex

Kavli Affiliate: Winrich Freiwald | Authors: Lucas Y Tian, Kedar U Garzón, Adam G Rouse, Mark AG Eldridge, Marc H Schieber, Xiao-Jing Wang, Joshua B Tenenbaum and Winrich A Freiwald | Summary: At the core of intelligence is proficiency in solving new problems, including those that differ dramatically from problems seen before. Problem-solving, in turn, […]


Continue.. Neural representation of action symbols in primate frontal cortex

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primates

Kavli Affiliate: Vincent Ferrera | Authors: Alec J. Batts, Robin Ji, Sua Bae, Fotios N. Tsitsos, Sergio Jiménez-Gambín, Nancy Kwon, Samantha L. Gorman, Deny Tsakri, Rebecca L. Noel, Jonas Bendig, Daniella A. Jimenez, Melody DiBenedetto, Sofia A. Del Castillo, Filimon B. Keleta, James Caicedo, Alexander Romanov, Colleen T. Curley, Yulia Dzhashiashvili, Greglynn D. Walton-Gibbs, Bradley […]


Continue.. Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primates