Intermittent Theta Burst Stimulation Drives Bi-Directional Changes in Excitability in Prefrontal Cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: Jyoti Mishra and Dhakshin Ramanathan | Authors: Morteza Salimi, Milad Nazari, Jonathan Mishler, Jyoti Mishra and Dhakshin Ramanathan | Summary: Summary: Theta burst stimulation (TBS), an FDA-cleared treatment for depression, is hypothesized to modulate excitability in the prefrontal cortex, though this has not definitively been shown in vivo. We performed calcium imaging on […]


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A Real-time Multi-Subject Three Dimensional Pose Tracking System for Analyzing Social Behaviors of Non-human Primates

Posted by dbos Hopkins

Kavli Affiliate: Xiaoqin Wang | Authors: Chaoqun Cheng, Zijian Huang, Ruiming Zhang, Guozheng Huang, Han Wang, Likai Tang and Xiaoqin Wang | Summary: Summary: The ability to track positions and poses (body parts) of multiple monkeys in a 3D space in real time is highly desired by non-human primate (NHP) researchers in behavioral and systems […]


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Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury

Posted by dbos Hopkins

Kavli Affiliate: David Linden | Authors: Patrick R Cooke and David J Linden | Summary: Summary: It is widely believed that axons in the central nervous system of adult mammals do not regrow following injury. This failure is thought, at least in part, to underlie the limited recovery of function following injury to the brain […]


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CellCover Captures Neural Stem Cell Progression in Mammalian Neocortical Development

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan and Laurent Younes | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Summary: Definition of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. Marker […]


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Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation

Posted by dbos Rockefeller

Kavli Affiliate: Robert B. Darnell | Authors: Ruth A Singer, Veronika Rajchin, Kwanghoon Park, Nathaniel Heintz and Robert B Darnell | Summary: Neuronal diversity and function are intricately linked to the dynamic regulation of RNA metabolism, including splicing, localization, and translation. Electrophysiologic studies of synaptic plasticity, models for learning and memory, are disrupted in Fragile […]


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CellCover Defines Temporal Progression in Conserved Cell Types and Informs oRG Evolution using scRNA-seq Data in Mammalian Neocortical Development

Posted by dbos Hopkins

Kavli Affiliate: Donald Geman and Laurent Younes | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Accurate identification of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. Such […]


Continue.. CellCover Defines Temporal Progression in Conserved Cell Types and Informs oRG Evolution using scRNA-seq Data in Mammalian Neocortical Development

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Katy Boerner, Philip D Blood, Jonathan C Silverstein, Matthew Ruffalo, Sarah A Teichmann, Gloria Pryhuber, Ravi S Misra, Jeffrey M Purkerson, Jean Fan, John W Hickey, Gesmira Molla, Chuan Xu, Yun Zhang, Griffin M Weber, Yashvardhan Jain, Danial Qaurooni, Yongxin Kong, Andreas Bueckle and Bruce W Herr II | […]


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Spontaneous calcium transients in hair cell stereocilia

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Saman Hussain, Miloslav Sedlacek, Runjia Cui, Wendy Zhang-Hooks, Dwight E Bergles, Jung-Bum Shin, Katie Kindt and Bechara Kachar | Summary: The hair bundle of auditory and vestibular hair cells converts mechanical stimuli into electrical signals through mechanoelectrical transduction (MET). The MET apparatus is built around a tip link that […]


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Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self

Posted by dbos UCSF

Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris and Christopher Timmermann | Summary: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory […]


Continue.. Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self

Relative phase of distributed oscillatory dynamics implements a working memory in a simple brain

Posted by dbos UCSF

Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: We report the existence of a working memory system in the nematode C. elegans that is employed for deferred action in a […]


Continue.. Relative phase of distributed oscillatory dynamics implements a working memory in a simple brain