Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Hannah Mummey, Weston Elison, Katha Korgaonkar, Ruth Elgamel, Parul Kudtarkar, Emily Griffin, Paola Benaglio, Michael Miller, Alokkumar Jha, Jocelyn E Manning Fox, Mark Mccarthy, Sebastian Preissl, Anna L Gloyn, Patrick E Macdonald and Kyle J Gaulton | Summary: Physiological variability in pancreatic cell type gene regulation and the impact […]


Continue.. Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Ashley L Kiemen, Cristina Almagro Perez, Valentina Matos Romero, André Forjaz, Alicia M Braxton, Lucie Dequiedt, Jeeun Parksong, Courtney D Cannon, Xuan Yuan, Sarah M Shin, Jaanvi Mahesh Babu, Elizabeth D Thompson, Toby C Cornish, Won Jin Ho, Laura D Wood, PeiHsun Wu, Arrate Munoz-Barrutia, Ralph H Hruban and […]


Continue.. 3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

Posted by dbos UCSF

Kavli Affiliate: Xin Duan | Authors: Travis D Goode, Jason Bondoc Alipio, Antoine Besnard, Devesh Pathak, Michael Kritzer-Cheren, Ain Chung, Xin Duan and Amar Sahay | Summary: Adaptive regulation of feeding depends on linkage of internal states and food outcomes with contextual cues. Human brain imaging has identified dysregulation of a hippocampal-lateral hypothalamic area (LHA) […]


Continue.. A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

Conservation, alteration, and redistribution of mammalian striatal interneurons

Posted by dbos UCSF

Kavli Affiliate: Alex Pollen | Authors: Emily K Corrigan, Michael DeBerardine, Aunoy Poddar, Miguel Turrero Garcia, Matthew T Schmitz, Corey Harwell, Mercedes Paredes, Fenna M Krienen and Alex Aaron Pollen | Summary: Mammalian brains vary in size, structure, and function, but the extent to which evolutionarily novel cell types contribute to this variation remains unresolved1–4. […]


Continue.. Conservation, alteration, and redistribution of mammalian striatal interneurons

A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: David Porubsky, Harriet Dashnow, Thomas A. Sasani, Glennis A. Logsdon, Pille Hallast, Michelle D. Noyes, Zev N. Kronenberg, Tom Mokveld, Nidhi Koundinya, Cillian Nolan, Cody J. Steely, Andrea Guarracino, Egor Dolzhenko, William T. Harvey, William J. Rowell, Kirill Grigorev, Thomas J. Nicholas, Keisuke K. Oshima, Jiadong Lin, Peter Ebert, […]


Continue.. A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]


Continue.. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Hierarchical gradients of multiple timescales in the mammalian forebrain

Posted by dbos Hopkins

Kavli Affiliate: Daeyeol Lee | Authors: Min Song, Eun Ju Shin, Hyojung Seo, Alireza Soltani, Nicholas A Steinmetz, Daeyeol Lee, Min Whan Jung and Se-Bum Paik | Summary: Many anatomical and physiological features of cortical circuits, ranging from the biophysical properties of synapses to the connectivity patterns among different neuron types, exhibit consistent variation along […]


Continue.. Hierarchical gradients of multiple timescales in the mammalian forebrain

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

Posted by dbos UCSF

Kavli Affiliate: Arturo Alvarez-Buylla Arnold R. Kriegstein Xin Duan | Authors: Li Wang, Cheng Wang, Juan A. Moriano, Songcang Chen, Guolong Zuo, Arantxa Cebrian-Silla, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Mengyi Song, Lilian G. de Oliveira, Qiuli Bi, Jonathan J. Augustin, Xinxin Ge, Mercedes F. Paredes, Eric J. Huang, Arturo Alvarez-Buylla, Xin Duan, Jingjing Li […]


Continue.. Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

Humans use local spectrotemporal correlations to detect rising and falling pitch

Posted by dbos Yale

Kavli Affiliate: Damon Clark | Authors: Parisa A Vaziri, Samuel D McDougle and Damon A Clark | Summary: To discern speech or appreciate music, the human auditory system detects how pitch increases or decreases over time. However, the algorithms used to detect changes in pitch, or pitch motion, are incompletely understood. Here, using psychophysics, computational […]


Continue.. Humans use local spectrotemporal correlations to detect rising and falling pitch

A microglia clonal inflammatory disorder in Alzheimer’s Disease

Posted by dbos Rockefeller

Kavli Affiliate: Damon Clark | Authors: Parisa A Vaziri, Samuel D McDougle and Damon A Clark | Summary: To discern speech or appreciate music, the human auditory system detects how pitch increases or decreases over time. However, the algorithms used to detect changes in pitch, or pitch motion, are incompletely understood. Here, using psychophysics, computational […]


Continue.. A microglia clonal inflammatory disorder in Alzheimer’s Disease