A multi-institutional investigation of psilocybin’s effects on mouse behavior

Kavli Affiliate: Vikaas Sohal and Mazen Kheirbek | Authors: Odilia D Lu, Katrina White, Kendall Raymond, Christine Liu, Alexandra S Klein, Nathaniel Green, Sam Vaillancourt, Austin Gallagher, Lena Shindy, Alyssa Li, Ruoxian Li, Mila Zou, Kira Wallquist, Austen B Casey, Lindsay P Cameron, Matthew B Pomrenze, Vikaas Sohal, Mazen A Kheirbek, Andrea M Gomez, Stephan […]


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Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami, Nick Belenko, Griffin Dennis, Cuidong Wang, Maria Esterlita Siantoputri, Yurie Maeda, Christina Pressl and Nathaniel Heintz | Summary: Fluorescent imaging enables visualization of the specific molecules of interest with high contrast, and the use of multiple fluorophores in a single tissue sample allows visualization of complex […]


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TUCL-Seq for miRNA single molecule sequencing

Kavli Affiliate: Li Zhao | Authors: Jicai Fan, Zhao Li, Xuejiao You, Lei Liu, Huan Jin, Ping Wu, Yushan Han, Lei Sun, Pengwei Xu, Yongfeng Liu, Jianjun Luo and Qin Yan | Summary: MicroRNAs (miRNAs) are pivotal regulatory molecules in gene expression, and their precise quantification is essential for elucidating their roles in diverse biological […]


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Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]


Continue.. Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]


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Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency

Kavli Affiliate: Robert B. Darnell | Authors: Maria Skamagki, Cheng Zhang, Ezgi Hacisuleyman, Giuseppe Galleti, Chao Wu, Rajasekhar K Vinagolu, HyoKyeong Cha, Deniz Ata, Jongjin Kim, Taylor Weiskittel, Mame Diop, Thiri Aung, Michael Del Latto, Amanda S. Kim, Zhuoning Li, Matthew Miele, Rui Zhao, Laura H. Tang, Ronald C. Hendrickson, Paul B. Romesser, Jesse Joshua […]


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Measuring the functional complexity of nanoscale connectomes: polarity matters

Kavli Affiliate: Carey Priebe and Joshua Vogelstein | Authors: Qingyang Wang, Nadine Randel, Yijie Yin, Cameron Shand, Amy Strange, Michael Winding, Albert Cardona, Marta Zlatic, Joshua Vogelstein and Carey Priebe | Summary: The emerging electron microscopy connectome datasets provides connectivity maps of the brains at single cell resolution, enabling us to estimate various network statistics, […]


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In vivo cell-type and brain region classification via multimodal contrastive learning

Kavli Affiliate: Liam Paninski | Authors: Han Yu, Hanrui Lyu, Ethan YiXun Xu, Charlie Windolf, Eric Kenji Lee, Fan Yang, Andrew M Shelton, Shawn Olsen, Sahar Minavi, Olivier Winter, The International Brain Laboratory, Eva L Dyer, Chandramouli Chandrasekaran, Nicholas A Steinmetz, Liam Paninski and Cole Hurwitz | Summary: Current electrophysiological approaches can track the activity […]


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pH-Sensitive Optical Nanocomposites Using Polymer-Coated Gold Nanorods

Kavli Affiliate: Xingde Li | Authors: Yongping Chen and Xingde Li | Summary: This study investigates the synthesis of pH-responsive, reversible nanocomposites comprising polystyrene sulfonate (PSS)-coated gold nanorods and poly(allylamine hydrochloride) (PAH)-coated gold nanorods, along with their optical properties. We observed a pH-dependent swelling/shrinking of the nanocomposites and a dramatic red-shift (~ 60 nm) of […]


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Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods

Kavli Affiliate: Denis Wirtz | Authors: AndrĂ© Forjaz, Donald Kramer, Yu Shen, Habin Bea, Margarita Tsapatsis, Jianglu Ping, Vasco Queiroga, Kyu Sang Han, Saurabh Joshi, Casey Grubel, Maria L. Beery, Irina Kusmartseva, Mark A. Atkinson, Ashley L Kiemen and Denis Wirtz | Summary: Nuclear morphology is an indicator of cellular function and disease states, as […]


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