Neuroscience – Page 10 – Kavli Institute Pre-Print Publications

Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice

Kavli Affiliate: Takaki Komiyama | Authors: Sonja Blumenstock, David Arakelyan, Nicholas del Grosso, Sonja Schneider, Yufeng Shao, Enida Gjoni, Ruediger Klein, Irina Dudanova and Takaki Komiyama | Summary: Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral […]

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Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study

Posted by dbos February 8, 2025February 19, 2025UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Xueying Chen, Hao Wang, Iris Broce, Anders M Dale, Bing Yu, Laura Y Zhou, Xihao Li, Maria Argos, Martha L Daviglus, Jianwen Cai, Nora Franceschini and Tamar Sofer | Summary: Hispanic/Latino populations are admixed, with genetic contributions from multiple ancestral populations. Studies of genetic association in these admixed populations […]

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Context-specific interaction of the lipid regulator DIP-2 with phospholipid synthesis in axon regeneration and maintenance.

Posted by dbos February 8, 2025February 19, 2025UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Seungmee Park, Andrew D. Chisholm and Yishi Jin | Summary: Neurons maintain their morphology over prolonged periods of adult life with limited regeneration after injury. C. elegans DIP-2 is a conserved regulator of lipid metabolism that affects axon maintenance and regeneration after injury. Here, we investigated genetic interactions of […]

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Evaluation of sequencing reads at scale using rdeval

Posted by dbos February 8, 2025February 19, 2025Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Bonhwang Koo, Marco Sollitto, Jennifer Balacco, Nadolina Brajuka, Richard Burhans, Erick Duarte, Alice Maria Giani, Kirsty McCaffrey, Jack A Medico, Eugene W Myers, Patrik Smeds, Anton Nekrutenko and Erich D Jarvis | Summary: Motivation: Large sequencing data sets are produced and deposited into public archives at unprecedented […]

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Optogenetic interrogation of the lateral-line sensory system reveals mechanisms of pattern separation in the zebrafish brain

Posted by dbos February 8, 2025February 19, 2025Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Nicolas Velez, Sihao Lu, Brian Fabella, Caleb C. Reagor, Holland R Brown, Yuriria Vazquez, Adrian Jacobo and Albert James Hudspeth | Summary: The ability of animals to interact with their environment hinges on the brain’s capacity to distinguish between patterns of sensory information and accurately attribute them to […]

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Neuronal Silencing and Protection in a Mouse Model of Demyelination

Posted by dbos February 6, 2025February 19, 2025Columbia

Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Julie Borovicka, Hale Tobin, Shruti Bhatia, Jacob Icardi, Ghazaal Tahmasebi, Priyanka Agochiya, Shriya Singh, Bruce Trapp and Hod Dana | Summary: Damage to the myelin sheath that protects axons in the central nervous system is a hallmark pathology of demyelinating diseases like multiple sclerosis. Cuprizone-induced demyelination in […]

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Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Posted by dbos February 6, 2025February 19, 2025UCSD / Salk

Kavli Affiliate: Kathleen Cullen and Vikram Chib | Authors: Jonathan Choy, Shadi Charara, Kalyani Cauwenberghs, Quintyn McKaughan, Keun-Young Kim, Mark Ellisman and Chih-Ying Su | Summary: Dendritic morphology is a defining characteristic of neuronal subtypes. In Drosophila, heterotypic olfactory receptor neurons (ORNs) expressing different receptors display diverse dendritic morphologies, but whether such diversity exists among […]

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Network Biomarkers of Alzheimer’s Disease Risk Derived from Joint Volume and Texture Covariance Patterns in Mouse Models

Posted by dbos February 6, 2025February 19, 2025Hopkins

Kavli Affiliate: Joshua Vogelstein | Authors: Eric W Bridgeford, Jaewon Chung, Robert J Anderson, Ali Mahzarnia, Jacques A Stout, Hae Sol Moon, Zay Yar Han, Joshua T Vogelstein and Alexandra Badea | Summary: Alzheimer’s disease (AD) lacks effective cures and is typically detected after substantial pathological changes have occurred, making intervention challenging. Early detection and […]

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A Generalist Intracortical Motor Decoder

Posted by dbos February 6, 2025February 19, 2025UCSF

Kavli Affiliate: Kristofer Bouchard | Authors: Joel Ye, Fabio Rizzoglio, Adam Smoulder, Hongwei Mao, Xuan Ma, Patrick Marino, Raeed H Chowdhury, Dalton D Moore, Gary Blumenthal, Will Hockeimer, Nicolas G. Kunigk, J Patrick Mayo, Aaron P Batista, Steven M Chase, Adam G Rouse, Michael L. Boninger, Charles Greenspon, Andrew B. Schwartz, Nicholas Hatsopoulos, Lee E […]

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The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

Posted by dbos February 5, 2025February 19, 2025Rockefeller

Kavli Affiliate: C. David Allis | Authors: Agata Lemiesz Patriotis, Yadira Soto-Feliciano, Douglas Barrows, Laiba Khan, Marylene Leboeuf, Peder Lund, Matthew R Marunde, Annaelle Djomo, Michael-Christopher Keogh, Thomas Carroll, Benjamin Garcia, Alexey A Soshnev and C. David Allis | Summary: Polycomb group proteins maintain gene expression patterns established during early development, with Polycomb Repressive Complex […]

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