Gut bacteria-derived succinate induces enteric nervous system regeneration

Kavli Affiliate: Daniel Mucida | Authors: Begüm Aydin, Izabela Mamede, Joana Cardoso, Julia Deere, Yelina Alvarez, Shanshan Qiao, Ved P. Sharma, Marissa A. Scavuzzo, Gregory P. Donaldson, Chun-Jun Guo and Daniel Mucida | Summary: Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion. Disruptions in microbial communities caused by antibiotics or enteric […]


Continue.. Gut bacteria-derived succinate induces enteric nervous system regeneration

Why do bats fly into cave doors? Inattentional blindness in echolocating animals

Kavli Affiliate: Cynthia F. Moss | Authors: Nikita M Finger, Keegan E Eveland, Xiaoyan Yin and Cynthia F Moss | Summary: Echolocating bats can navigate complex 3D environments by integrating prior knowledge of spatial layouts and real-time sensory cues. This study demonstrates that inattentional blindness to sensory information undermines successful navigation in Egyptian fruit bats, […]


Continue.. Why do bats fly into cave doors? Inattentional blindness in echolocating animals

Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease

Kavli Affiliate: Arnold R. Kriegstein | Authors: Beika Zhu, Andi Wangzhou, Diankun Yu, Tao Li, Rachael Schmidt, Stacy L. De Florencio, Lauren Chao, Yonatan Perez, Lea Tenenholz Grinberg, Salvatore Spina, Richard M Ransohoff, Arnold Kriegstein, William W Seeley, Tomasz J. Nowakowski and Xianhua Piao | Summary: Germline genetic architecture of Alzheimer’s disease (AD) indicates microglial […]


Continue.. Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease

Role of dopamine in reward expectation and predictability during execution of action sequences

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Yifeng Cheng, Joanna Zhou, Haley Province, Nathalie Thiriet, Patricia H Janak and Youna Vandaele | Summary: Reward-associated cues serve different functions depending on whether they precede or terminate action sequences. Cues that precede action sequences and signal opportunity for reward could serve as GO signals to initiate […]


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HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease

Kavli Affiliate: Michael Miller | Authors: Emmanuel C Ijezie, Michael J Miller, Celine Hardy, Ava R Jarvis, Timothy Czajka, Lianna D’Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy and David Butler | Summary: INTRODUCTION Herpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer’s Disease (AD) in neurons. One key marker of AD is the […]


Continue.. HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease

Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches

Kavli Affiliate: Sarah Woolley | Authors: Isabella Catalano and Sarah C Woolley | Summary: Social and sensory experiences across the lifespan can shape social interactions, however, experience-dependent plasticity is widely studied within discrete life stages. In the socially monogamous zebra finch, in which females use learned vocal signals to identify individuals and form long-lasting pair […]


Continue.. Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches

Discovering Cognitive Strategies with Tiny Recurrent Neural Networks

Kavli Affiliate: Marcelo Mattar | Authors: Li Ji-An, Marcus K Benna and Marcelo G Mattar | Summary: Normative modeling frameworks such as Bayesian inference and reinforcement learning provide valuable insights into the fundamental principles governing adaptive behavior. While these frameworks are valued for their simplicity and interpretability, their reliance on few parameters often limits their […]


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Complete sequencing of ape genomes

Kavli Affiliate: Erich Jarvis | Authors: DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R. […]


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Why do we have so many excitatory neurons?

Kavli Affiliate: Carey Priebe and Joshua Vogelstein | Authors: Qingyang Wang, Albert Cardona, Marta Zlatic, Joshua Vogelstein and Carey Priebe | Summary: Approximately four in five neurons are excitatory. This is true across functional regions and species. Why do we have so many excitatory neurons? Little is known. Here we provide a normative answer to […]


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Quantifying transcriptome turnover on phylogenies by modeling gene expression as a binary trait

Kavli Affiliate: Li Zhao | Authors: Ammon Thompson, Michael R. May, Ben Hopkins, Nerisa Riedl, Olga Barmina, Benjamin J. Liebeskind, Li Zhao, David Begun and Artyom Kopp | Summary: Changes in gene expression are a key driver of phenotypic evolution, leading to a persistent interest in the evolution of transcriptomes. Traditionally, gene expression is modeled […]


Continue.. Quantifying transcriptome turnover on phylogenies by modeling gene expression as a binary trait