xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales

Posted by dbos Hopkins

Kavli Affiliate: Laurent Younes and Michael Miller | Authors: Kaitlin Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouve and Michael I Miller | Summary: Advancements in imaging and molecular techniques enable the collection of subcellular-scale data. Diversity in measured features, resolution, and physical scope of capture across technologies and experimental protocols pose […]


Continue.. xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales

Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: William R Thomas, Tanya M Lama, Diana Moreno-Santillan, Marta Farre, Cecilia Baldoni, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Alan Tracey, David A Ray, Dina K. N. Dechmann, Dominik von Elverfeldt, John Nieland, Angelique P Corthals, Erich Jarvis and Liliana M Davalos […]


Continue.. Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew

Credit Assignment via Behavioral Timescale Synaptic Plasticity: Theoretical Frameworks

Posted by dbos Columbia

Kavli Affiliate: Rui Costa | Authors: Ian Cone, Claudia Clopath and Rui Ponte Costa | Summary: Behavioral Timescale Synaptic Plasticity (BTSP) is a form of synaptic plasticity in which dendritic Ca2+ plateau potentials in hippocampal pyramidal neurons drive rapid place field formation. Unlike traditional learning rules, BTSP learns correlations on the timescales of seconds and […]


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Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Tyler Santander, Selin Bekir, Theresa Paul, Jessica M Simonson, Valerie M Wiemer, Henri Etel Skinner, Johanna L Hopf, Anna Rada, Friedrich G Woermann, Thilo Kalbhenn, Barry Giesbrecht, Christian G Bien, Olaf Sporns, Michael S Gazzaniga, Lukas J Volz and Michael B Miller | Summary: The dynamic integration of the […]


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The selective dynamics of interruptions at short tandem repeats

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Michael E Goldberg, Harriet Dashnow, Kelley Harris and Aaron R Quinlan | Summary: Short tandem repeats (STRs) are hotspots of genomic instability that mutate at rates orders of magnitude greater than non-repetitive loci due to frequent replication slippage. Expansions at some STR loci cause Mendelian diseases, while variation at […]


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JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux

Posted by dbos Yale

Kavli Affiliate: Shawn Ferguson | Authors: Layla M Nassar, xiaojian Shi, Agnes Roczniak-Ferguson, Hongying Shen and Shawn M Ferguson | Summary: Lysosomes break down macromolecules, clear cellular waste and recycle nutrients such as cystine. We describe a novel mechanism whereby JIP4 regulates lysosomal cystine storage by controlling the abundance of cystinosin (CTNS), the transporter responsible […]


Continue.. JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux

Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity

Posted by dbos Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: Karina Chaudhari, Luis E Guzman-Clavel and Alex L Kolodkin | Summary: There is great diversity in retinal ganglion cells subtypes in the mouse retina, but little is known about the molecular factors required to generate this subtype diversity. Here, we identify the transcription factor Gfi1 as a conserved driver […]


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An improved model for prediction of de novo designed proteins with diverse geometries

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Benjamin Orr, Stephanie E Crilly, Deniz Akpinaroglu, Eleanor Zhu, Michael J. Keiser and Tanja Kortemme | Summary: Nature uses structural variations on protein folds to fine-tune the geometries of proteins for diverse functions, yet deep learning-based de novo protein design methods generate highly regular, idealized protein fold geometries that […]


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Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain

Posted by dbos UCSF

Kavli Affiliate: Arnold R. Kriegstein | Authors: Chujing Zhang, Eugene Gil, Sajad Hamid Ahanger, Mingcong Li, Li Wang, Eric J. Huang, Jingjing Li, Arnold R. Kriegstein and Daniel A. Lim | Summary: Approximately 30-40% of the human genome is anchored to the nuclear lamina (NL) through variably sized (10 kb-10 Mb) lamina-associated domains (LADs), which […]


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Fentanyl reinforcement history has sex-specific effects on multi-step decision-making

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Authors: Eric Garr, Yifeng Cheng, Andy Dong and Patricia H. Janak | Summary: It is commonly thought that drug addiction involves a transition to habitual control of action, where the choice to consume drugs becomes automatized and reflects a failure to deliberate over possible negative outcomes. Determining whether the pursuit […]


Continue.. Fentanyl reinforcement history has sex-specific effects on multi-step decision-making