ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Kavli Affiliate: Pietro De Camilli | Authors: Devin M Fuller, Yumei Wu, Florian Schueder, Burha Rasool, Shanta Nag, Justin L. Korfhage, Rolando Garcia-Milian, Katerina D Melnyk, Joerg Bewersdorf, Pietro De Camilli and Thomas Melia | Summary: Autophagosomes form from seed membranes that expand through bulk-lipid transport via the bridge-like lipid transporter ATG2. The origins of […]


Continue.. ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Seasonal brain regeneration and chromosome instability are linked to selection on DNA repair in Sorex araneus

Kavli Affiliate: Erich Jarvis | Authors: William R Thomas, Tanya M Lama, Diana Moreno-Santillan, Marta Farre, Cecilia Baldoni, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Alan Tracey, David A Ray, Dina K. N. Dechmann, Dominik von Elverfeldt, John Nieland, Angelique P Corthals, Erich Jarvis and Liliana M Davalos […]


Continue.. Seasonal brain regeneration and chromosome instability are linked to selection on DNA repair in Sorex araneus

Hippocampus facilitates reinforcement learning under partial observability

Kavli Affiliate: Rui Costa | Authors: Dabal Pedamonti, Samia Mohinta, Martin Dimitrov, Hugo Malagon-Vina, Stephane Ciocchi and Rui Ponte Costa | Summary: Mastering navigation in environments with limited visibility is crucial for survival. Although the hippocam-pus has been associated with goal-oriented navigation, its role in real-world behaviour remains unclear. To investigate this, we combined deep […]


Continue.. Hippocampus facilitates reinforcement learning under partial observability

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Kavli Affiliate: Seth Shipman Eiman Azim | Authors: Abdulkadir Ozkan, Hari K Padmanabhan, Seth Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, Nazli Basak and Jeffrey D Macklis | Summary: Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) […]


Continue.. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

Kavli Affiliate: Jeremy Nathans | Authors: Yanshu Wang, Amir Rattner, Zhongming Li, Philip M Smallwood and Jeremy Nathans | Summary: Cajal-Retzius (CR) cells are glutamatergic neurons that transiently populate the most superficial layer of the isocortex and allocortex during development, serving an essential role during both prenatal and early postnatal brain development. Notably, these cells […]


Continue.. Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

Kavli Affiliate: Arnold R. Kriegstein | Authors: Tanzila Mukhtar, Clara-Vita Siebert, Yuejun Wang, Mark-Phillip Pebworth, Matthew L. White, Tianzhi Wu, Tan Ieng Huang, Guolong Zuo, Jayden Ross, Jennifer Baltazar, Varun Upadhyay, Merut Shankar, Li Zhou, Isabel Lombardi-Coronel, Ishaan Mandala, Manal A. Adam, Shaohui Wang, Qiuli Bi, Marco F.M. Hoekman, Jingjing Li and Arnold Kriegstein | […]


Continue.. α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

Differences in Cajal-Retzius cell density and postnatal persistence across cortical areas revealed by a novel intersectional genetic labeling approach

Kavli Affiliate: Giulia Quattrocolo | Authors: Kristian Moan, Robert P Machold and Giulia Quattrocolo | Summary: Cajal-Retzius (CR) cells are glutamatergic neurons that transiently populate the most superficial layer of the isocortex and allocortex during development, serving an essential role during both prenatal and early postnatal brain development. Notably, these cells disappear from most cortical […]


Continue.. Differences in Cajal-Retzius cell density and postnatal persistence across cortical areas revealed by a novel intersectional genetic labeling approach

Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins

Kavli Affiliate: Robert Edwards | Authors: Aaron J May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Moumita Dutta, Maggie Barr, Rob Parks, Xiaozhi Lu, Madison Berry, Amanda Newman, Xiao Huang, Kijun Song, Victor Ilevbare, Salam Sammour, Chan Soo Park, Radha Devkota Adhikari, Priyanka Devkota, Katarzyna Janowska, Yanshun Liu, Garrett Scapellato, Taylor N Spence, Katayoun […]


Continue.. Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins

Monkey See, Model Knew: Large Language Models Accurately Predict Visual Brain Responses in Humans AND Non-Human Primates

Kavli Affiliate: George A. Alvarez | Authors: Colin Conwell, Emalie McMahon, Akshay Jagadeesh, Kasper Vinken, Saloni Sharma, Jacob S. Prince, George Alvarez, Talia Konkle, Margaret Livignstone and Leyla Isik | Summary: Recent progress in multimodal AI and ‘language-aligned’ visual representation learning has rekindled debates about the role of language in shaping the human visual system. […]


Continue.. Monkey See, Model Knew: Large Language Models Accurately Predict Visual Brain Responses in Humans AND Non-Human Primates

CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity

Kavli Affiliate: Laurent Younes and Donald Geman | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Seungmae Seo, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Definition of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. […]


Continue.. CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity