Neuroscience – Page 10 – Kavli Institute Pre-Print Publications

Exploiting Endogenous Cas9-Based Genome Editing of Lacticaseibacillus rhamnosus GG (LGG) for Precision Food Fermentation and Live Biotherapeutics

Posted by dbos January 21, 2025February 5, 2025Hopkins

Kavli Affiliate: Michael Miller | Authors: Zifan Xie, Yong-Su Jin and Michael J Miller | Summary: Lacticaseibacillus rhamnosus GG (LGG) is one of the most studied probiotic strains and is widely used in both food and therapeutic industries. With its safe and health-beneficial properties, LGG is an ideal candidate for genome modification to enhance its […]

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Whole-brain neural substrates of behavioral variability in the larval zebrafish

Posted by dbos January 20, 2025January 30, 2025Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Jason Manley and Alipasha Vaziri | Summary: Animals engaged in naturalistic behavior can exhibit a large degree of behavioral variability even under sensory invariant conditions. Such behavioral variability can include not only variations of the same behavior, but also variability across qualitatively different behaviors driven by divergent cognitive states, […]

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The effects of task similarity during representation learning in brains and neural networks

Posted by dbos January 20, 2025January 30, 2025Columbia

Kavli Affiliate: Stefano Fusi | Authors: Nicholas Menghi, William Jeffrey Johnston, Simone Vigano’, Max Andreas Bosse Hinrichs, Burkhard Maess, Stefano Fusi and Christian F Doeller | Summary: The complexity of our environment poses significant challenges for adaptive behavior. Recognizing shared structures across tasks can theoretically improve learning through generalization. However, how such shared representations emerge […]

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MetaLigand: A database for predicting non-peptide ligand mediated cell-cell communication

Posted by dbos January 19, 2025January 30, 2025Hopkins

Kavli Affiliate: Richard Axel | Authors: Andrew Jacob Pixley Fink, Samuel Muscinelli, Shuqi Wang, Marcus I Hogan, Daniel Fine English, Richard Axel, Ashok Litwin-Kumar and Carl E. Schoonover | Summary: Non-peptide ligands (NPLs), including lipids, amino acids, carbohydrates, and non-peptide neurotransmitters and hormones, play a critical role in ligand-receptor-mediated cell-cell communication, driving diverse physiological and […]

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Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity

Posted by dbos January 17, 2025January 30, 2025UCSF

Kavli Affiliate: Robert Edwards | Authors: Parker J. Jamieson, Xiaoying Shen, Alexandra A. Abu-Shmais, Perry T. Wasdin, Katarzyna Janowska, Robert J. Edwards, Garrett Scapellato, Simone I. Richardson, Nelia P. Manamela, Shuying Liu, Maggie Barr, Rebecca A. Gillespie, Jessica Mimms, Naveenchandra Suryadevara, Ty A. Sornberger, Seth Zost, Rob Parks, Shelby Flaherty, Alexis K. Janke, Bethany N. […]

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Experience-dependent reorganization of inhibitory neuron synaptic connectivity

Posted by dbos January 16, 2025January 30, 2025Columbia

Kavli Affiliate: Richard Axel | Authors: Andrew Jacob Pixley Fink, Samuel Muscinelli, Shuqi Wang, Marcus I Hogan, Daniel Fine English, Richard Axel, Ashok Litwin-Kumar and Carl E. Schoonover | Summary: Organisms continually tune their perceptual systems to the features they encounter in their environment1–3. We have studied how ongoing experience reorganizes the synaptic connectivity of […]

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Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation

Posted by dbos January 15, 2025January 30, 2025Rockefeller

Kavli Affiliate: Robert B. Darnell and Nathaniel Heintz | Authors: Ruth A Singer, Veronika Rajchin, Kwanghoon Park, Nathaniel Heintz and Robert B Darnell | Summary: Neuronal diversity and function are intricately linked to the dynamic regulation of RNA metabolism, including splicing, localization, and translation. Electrophysiologic studies of synaptic plasticity, models for learning and memory, are […]

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Atlas of plasma metabolic markers linked to human brain morphology

Posted by dbos January 14, 2025January 30, 2025Hopkins, UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Dennis van der Meer, Jakub Kopal, Alexey Shadrin, Julian Fuhrer, Jaroslav Rokicki, Sara Stinson, Srdjan Djurovic, Anders Dale and Ole Andreassen | Summary: Background Metabolic processes form the basis of the development, functioning and maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in brain […]

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Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility

Posted by dbos January 14, 2025January 30, 2025Hopkins

Kavli Affiliate: Richard Huganir | Authors: Julia Brill, Blaise Clarke, Ingie Hong and Richard L. Huganir | Summary: SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through […]

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Convergence of autism proteins at the cilium

Posted by dbos January 14, 2025January 30, 2025Rockefeller

Kavli Affiliate: Jeremy Willsey | Authors: Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, David B. Kastner, Aliza T. Ehrlich, Matthew W. State, A. Jeremy Willsey and Helen […]

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