Shared and distinct cortical mechanisms for working memory and decision-making.

Kavli Affiliate: Daeyeol Lee | Authors: Hyojung Seo, Daeyeol Lee and Shanna K Murray | Summary: The dorsolateral prefrontal cortex (DLPFC) and lateral intraparietal cortex (LIP) in the primate brain are critically involved in working memory during tasks that require the retention of information over a delay. These same regions have also been implicated in […]


Continue.. Shared and distinct cortical mechanisms for working memory and decision-making.

Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Kavli Affiliate: Alexandra Nelson | Authors: Rodrigo M Paz, Michael B Ryan, Pamela F Marcott, Allison E Girasole, Joseph Faryean, Vincent Duong, Sadhana Sridhar and Alexandra B Nelson | Summary: The use of levodopa to manage Parkinson’s disease (PD) symptoms leads to levodopa-induced dyskinesia (LID) and other motor fluctuations, which worsen with disease progression and […]


Continue.. Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Kavli Affiliate: Michael Miller | Authors: Maria Luisa Amaral, Sainath Mamde, Michael Miller, Xiaomeng Hou, Jessica Arzavala, Julia Osteen, Elizabeth Walker Smoot, Qian Yang, Emily Eisner, Qiurui Zeng, Cindy Tatiana Baez-Becerra, Jacqueline Olness, Joseph Colin Kern, Jonathan Rink, Nicholas Johnson, Ariana Barcoma, Silvia Cho, Stella Cao, Nora Emerson, Jasper Lee, Jackson Willier, Timothy Loe, Henry […]


Continue.. Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth

Kavli Affiliate: Martin Lindquist | Authors: Heather Shappell, Zhiyuan Liu, Mohammadreza Khodaei, George He, Dylan Gee, Martin Lindquist, Denis G. Sukhodolsky, Gregory McCarthy and Karim Ibrahim | Summary: Background Childhood disruptive behavior problems are linked to aberrant integrity within large-scale cognitive control networks. However, it is unclear if transitory or dynamic variation in the functional […]


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Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

Kavli Affiliate: Hana El-Samad | Authors: Achal Mahajan, Francesca Ratti, Ban Wang, Hana El-Samad, James H. Kaufman and Vishrawas Gopalakrishnan | Summary: Regulation of gene expression is fundamental for proper cellular function, and is constrained by the local chromatin environment of each gene, which varies spatially along the chromosome and is shaped by epigenetic modifications. […]


Continue.. Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Kavli Affiliate: Robert Edwards | Authors: Mera F. Liccione, Trevor Scobey, Heather M. Froggatt, Camryn Pajon, Boyd L. Yount, Qi Yin, Taylor N. Spence, Emmanuel B. Walter, Kevin O. Saunders, Robert J. Edwards, Ralph S. Baric, Barton F. Haynes, Derek W. Cain, Timothy P. Sheahan and Daniel Wrapp | Summary: HCoV-229E is an endemic Alphacoronavirus […]


Continue.. A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Early development of direction selectivity in higher visual cortex

Kavli Affiliate: Kristina Nielsen | Authors: Dallas C Khamiss, Augusto A Lempel, Brandon R Nanfito and Kristina Juliane Nielsen | Summary: A fundamental aspect of visual motion processing is the computation of motion direction. In ferrets, as in primates, selectivity for motion direction is found both in early cortical stages like the primary visual cortex […]


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Condenzymes: Biomolecular condensates with inherent catalytic activities

Kavli Affiliate: Wei Min | Authors: Michael W Chen, Xiao Guo, Mina Farag, Naixin Qian, Xiaowei Song, Anton Ni, Vicky Liu, Xia Yu, Yuefeng Ma, Leshan Yang, Wen Yu, Matthew King, Joonho Lee, Richard N Zare, Wei Min, Rohit V Pappu and Yifan Dai | Summary: We report the discovery that chemical reactions can be […]


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Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

Kavli Affiliate: Devanand Manoli | Authors: Alexis M Black, Natsumi Komatsu, Jiaxuan Zhao, Scarlet R Taskey, Nicole S Serrano, Ruchira Sharma, Devanand S. Manoli, Markita P Landry and Annaliese Beery | Summary: Friendships, or selective peer relationships, are a vital component of healthy social functioning in humans, while deficits in these relationships are associated with […]


Continue.. Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Kavli Affiliate: Anders Dale and Wesley Thompson | Authors: Pravesh Parekh, Nadine Parker, Diliana Pecheva, Evgeniia Frei, Marc Vaudel, Diana M. Smith, Alison Rigby, Piotr Jahołkowski, Ida Elken Sønderby, Viktoria Birkenæs, Nora Refsum Bakken, Chun Chieh Fan, Carolina Makowski, Jakub Kopal, Robert John Loughnan, Donald J. Hagler, Jr., Dennis van der Meer, Stefan Johansson, Pål […]


Continue.. FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets