Enhancer-driven regulatory network of forebrain human development provides insights into autism

Posted by klaurent This Week: Neuroscience, Yale

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]


Continue.. Enhancer-driven regulatory network of forebrain human development provides insights into autism

Separable global and local beta burst dynamics in motor cortex of primates

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Karunesh Ganguly | Authors: Preeya Khanna, behraz farrokhi, Hoseok Choi, Sandon Griffin, Ian Heimbuch, Lisa Novik, Katherina Thiesen, John H Morrison, Robert Morecraft and Karunesh Ganguly | Summary: Sensorimotor beta band oscillations are known to modulate during normal movement control and abnormal beta modulation is linked to pathological bradykinesia. However, the functional differences […]


Continue.. Separable global and local beta burst dynamics in motor cortex of primates

Seizure-induced Transient Disruptive Changes in Brain Microstructure

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Akihiro Takamiya, Frank Riemer, Vera Jane Erchinger, Max Korbmacher, Hauke Bartsch, Olga Therese Ousdal, Ivan Maximov, Anders Dale, Louise Emsell, Ketil Joachim Oedegaard, Ute Kessler and Leif Oltedal | Summary: A leading hypothesis for the mechanisms of electroconvulsive therapy (ECT) posits an initial disruptive effect followed by enhanced neuroplasticity. […]


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Diverse and Flexible Strategies Enable Successful Cooperation in Marmoset Dyads

Posted by dbos This Week: Neuroscience, Yale

Kavli Affiliate: Anirvan Nandy | Authors: Olivia C Meisner, Weikang Shi, Amrita Nair, Gargi Nandy, Monika P Jadi, Anirvan S Nandy and Steve W. C. Chang | Summary: In humans, cooperation relies on advanced social cognition, but the extent to which these mechanisms support cooperation in nonhuman primates remains unclear. To investigate this, we examined […]


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Synaptic vesicles that store monoamines and glutamate differ in protein composition.

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Robert Edwards | Authors: Hrach Asmerian, Alexia J. Diaz, Hongfei Xu, Juan A Oses-Prieto, Jacob Alberts, Anna M. Sanetra, Barathan Gnanabharathi, Noah Carr, Alma L. Burlingame, Robert H. Edwards and Katlin Silm | Summary: Neuromodulators such as the monoamines are known to differ from classical neurotransmitters like glutamate in the time scale of […]


Continue.. Synaptic vesicles that store monoamines and glutamate differ in protein composition.

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Robert Edwards | Authors: Rumi Habib, Ryan S. Roark, Hui Li, Andrew Jesse Connell, Michael P. Hogarty, Kshitij Wagh, Shuyi Wang, Lorie Marchitto, Ashwin N. Skelly, John W. Carey, Kirsten J. Sowers, Kasirajan Ayyanathan, Samantha J. Plante, Frederic Bibollet-Ruche, Younghoon Park, Colby J. Agostino, Ajay Singh, Christian L. Martella, Emily Lewis, Jinery Lora, […]


Continue.. Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Dynamics of auditory word form encoding in human speech cortex

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Edward Chang | Authors: Yizhen Zhang, Matthew K Leonard, Laura Gwilliams, Ilina Bhaya-Grossman and Edward F Chang | Summary: When we hear continuous speech, we perceive it as a series of discrete words, despite the lack of clear boundaries in the acoustic signal. The superior temporal gyrus (STG) encodes phonetic elements like consonants […]


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Theory of interaction between untuned modulatory inputs and tuned sensory inputs

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Tuan Nguyen, Agostina Palmigiano and Kenneth D Miller | Summary: How does the brain integrate sensory inputs with non-feature-tuned signals, such as those arising from behavioral state changes or neuromodulation? Here, we show that the dynamics of disordered E/I networks with structured, feature-dependent connectivity can be well characterized by […]


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Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Patrick Leavey, Lizhi Jiang, Nicole Pannullo, Clayton Santiago and Seth BlackshawLyndsey M Kirk, Guadalupe C Garcia, Dakota C Hanka, Kyle Zatyko, Thomas M Bartol, Terrence J Sejnowski and Kristen M. Harris | Summary: Long-term potentiation (LTP) induces presynaptic bouton enlargement and a reduction in the number of synaptic vesicles. […]


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Overexpression of Meis factors in late-stage retinal progenitors yields complex effects on temporal patterning and neurogenesis.

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Patrick Leavey, Lizhi Jiang, Nicole Pannullo, Clayton Santiago and Seth Blackshaw | Summary: The vertebrate retina serves as a model for studying neurogenesis and cell fate specification, with retinal progenitor cells following a tightly regulated temporal sequence to generate distinct cell types. Meis1 and Meis2 are transcription factors implicated […]


Continue.. Overexpression of Meis factors in late-stage retinal progenitors yields complex effects on temporal patterning and neurogenesis.