Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Eric D. Siggia | Authors: Stefano Fusi and Liam Paninski | Summary: The brain is highly structured both at anatomical and functional levels. However, within individual brain areas, neurons often exhibit very diverse and seemingly disorganized responses. A more careful analysis shows that these neurons can sometimes be grouped together into specialized subpopulations […]


Continue.. Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Quantitative guiding of developmental cell fate transitions using gene-free modelling

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Eric D. Siggia | Authors: Ismail Hajji, Eric D Siggia, Francis Corson and Wolfgang Keil | Summary: During development, cells gradually assume specialized fates via changes of transcriptional dynamics in thousands of genes. Terminal cell identities are then stabilized through the convergence of gene regulatory network dynamics and the accumulation of epigenetic DNA […]


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Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs, Yonatan Sanz Perl, Adrian Ponce-Alvarez, Sebastian Idesis, Manesh Girn, Leor Roseman, Jennifer M Mitchell, Adam Gazzaley, Morten Kringelbach, David J Nutt, Taylor Lyons, Robin L Carhart-Harris and Gustavo Deco | Summary: Psilocybin has been shown to induce fast and sustained improvements in mental […]


Continue.. Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Alex Pollen | Authors: Sara Nolbrant, Jenelle L. Wallace, Jingwen Ding, Tianjia Zhu, Jess L. Sevetson, Janko Kajtez, Isabella A. Baldacci, Emily K. Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T. Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J. Pavlovic, Sofie R. Salama, Agnete Kirkeby, Hao Huang, Nathan K. Schaefer and Alex A. […]


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Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Jeziel D Damasceno, Gabriel LA Silva, Catarina A Marques, Marija Krasilnikova, Craig Lapsley, Dario Beraldi and Richard McCulloch | Summary: Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from population-based techniques, with only […]


Continue.. Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Ann McDermott | Authors: Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Marko Jovanovic, Ann E McDermott, Daniel A Keedy and Neel H Shah | Summary: The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. […]


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Optogenetic Central Amygdala Stimulation is Highly Reinforcing and Strongly Outcompetes Fentanyl Self-Administration in Male, but not Female, Rats

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Authors: Emma Chaloux-Pinette, Maricela Vela Mirelez-Prince, Samantha Soto, Kirtana Ananth, Xiao Tong, Vanessa Silva, Daniela Rodriguez and Patricia H Janak | Summary: The central nucleus of the amygdala plays a key role in many aspects of substance use disorders, in particular biasing behaviors toward one drug or natural reward over […]


Continue.. Optogenetic Central Amygdala Stimulation is Highly Reinforcing and Strongly Outcompetes Fentanyl Self-Administration in Male, but not Female, Rats

Cephalopod Sex Determination and its Ancient Evolutionary Origin

Posted by dbos Columbia

Kavli Affiliate: Scott Small | Authors: Gabrielle C. Coffing, Silas Tittes, Scott T. Small, Jeremea O. Songco-Casey, Denise M. Piscopo, Judit R. Pungor, Adam C Miller, Cristopher Niell and Andrew D. Kern | Summary: Octopuses, squids, and cuttlefishes – the coleoid cephalopods – are a remarkable branch in the tree of life whose members exhibit […]


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Recurrent Connectivity Shapes Spatial Coding in Hippocampal CA3 Subregions

Posted by dbos Columbia

Kavli Affiliate: Darcy Peterka and Attila Losonczy | Authors: Eunji Kong, Erfan Zabeh, Zhenrui Liao, Tiberiu S. Mihaila, Darcy S. Peterka, Caroline Wilson, Charan Santhirasegaran, Attila Losonczy and Tristan Geiller | Summary: Stable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments. However, how these distinct representations emerge from […]


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Ultrastructural correlates of circadian structural plasticity

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Juan I. Ispizua, Micaela Rodriguez-Caron, Francisco J. Tassara, Kim Keun-young, Catalina Insusarry Perkins, Milagros Barzi, Christian Carpio-Romero, Celia N. Hansen, Julian Gargiulo, Ezio Rosato, Horacio de la iglesia, Mark Ellisman and M. Fernanda Ceriani | Summary: The central clock in the Drosophila’s brain consists of approximately 250 neurons organized […]


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