Neuroscience – Kavli Institute Pre-Print Publications

Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis

Posted by dbos October 26, 2024October 28, 2024Columbia, This Week: Neuroscience

Kavli Affiliate: Michael Goldberg | Authors: Saeko Takada, Bonnie J. Bolkan, MaryJane O’Connor, Michael Goldberg and Michael B. O’Connor | Summary: Toys are us (Trus) is the Drosophila ortholog of mammalian Programmed Cell Death 2-Like (PDCD2L), a protein that has been implicated in ribosome biogenesis, cell cycle regulation, and oncogenesis. In this study, we examined […]

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Encoding manifolds constructed from grating responses organize responses to natural scenes in cortical visual areas

Posted by dbos October 26, 2024October 28, 2024This Week: Neuroscience, UCSF

Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Greg D Field, Michael P Stryker and Steven W Zucker | Summary: We have created “encoding manifolds” to reveal the overall responses of a brain area to a variety of stimuli. Encoding manifolds organize response properties globally: each point on an encoding manifold is a neuron, and […]

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Closed-loop modulation of remote hippocampal representations with neurofeedback

Posted by dbos October 24, 2024October 28, 2024This Week: Neuroscience, UCSF

Kavli Affiliate: Loren Frank | Authors: Michael E. Coulter, Anna K. Gillespie, Joshua P Chu, Eric L. Denovellis, Trevor T.K. Nguyen, Daniel Liu, Katherine Wadhwani, Biabhav Sharma, Kevin Wang, Xinyi Deng, Uri Eden, Caleb Kemere and Loren M. Frank | Summary: Humans can remember specific events without acting on them and can influence which memories […]

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Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson′s disease and Dementia with Lewy bodies

Posted by dbos This Week: Neuroscience, Yale

Kavli Affiliate: Sreeganga Chandra | Authors: D J Vidyadhara, David Backstrom, Risha Chakraborty, Jiapeng Ruan, Jae-Min Park, Pramod K. Mistry and Sreeganga S. Chandra | Summary: GBA mutations are major risk factors for Parkinson′s disease (PD) and Dementia with Lewy Bodies (DLB), two common α-synucleinopathies associated with cognitive impairment. Here, we investigated the role of […]

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Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke

Posted by dbos October 23, 2024October 28, 2024This Week: Neuroscience, UCSF

Kavli Affiliate: Michael Stryker | Authors: Yoshimichi Sato, Yuandong Li, Yuya Kato, Atsushi Kanoke, Yujiao Jennifer Sun, Yasuo Nishijima, Ruikang K Wang, Michael Stryker, Hidenori Endo and Jialing Liu | Summary: Type 2 diabetes mellitus (T2DM) is associated with impaired leptomeningeal collateral compensation and poor stroke outcome. Neutrophils tethering and rolling on endothelium after stroke […]

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Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration

Posted by dbos October 23, 2024October 28, 2024This Week: Neuroscience, UCSF

Kavli Affiliate: Bjoern Schwer | Authors: Sarah Cohen, Laura Cheradame, Karishma Pratt, Sarah Collins, Ashlie Barillas, Annika Carlson, Vijay Ramani, Gaelle Legube, Saul Villeda, Dyche Mullins and Bjoern Schwer | Summary: Loss of genomic information due to the accumulation of somatic DNA damage has been implicated in aging and neurodegeneration. Somatic mutations in human neurons […]

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Dorsal-caudal and ventral hippocampus target different cell populations in the medial frontal cortex in rodents

Posted by dbos October 22, 2024October 28, 2024NTNU, This Week: Neuroscience

Kavli Affiliate: Menno Witter | Authors: Paola Alemán-Andrade, Menno P. Witter, Ken-Ichiro Tsutsui and Shinya Ohara | Summary: Direct projections from the ventral hippocampus (vHPC) to the medial frontal cortex (MFC) play crucial roles in memory and emotional regulation. Using anterograde transsynaptic tracing and in vitro electrophysiology in mice, we document a previously unexplored pathway […]

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Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

Posted by dbos October 18, 2024October 28, 2024Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Michael S Totty, Rita Cervera-Juanes, Svitlana V Bach, Lamya Ben Ameur, Madeline R Valentine, Evan Simons, Mckenna D Romac, Hoa Trinh, Krystal Henderson, Ishbel Del Rosario, Madhavi Tippani, Ryan A Miller, Joel E Kleinman, Stephanie Cerceo Page, Arpiar Saunders, Thomas M Hyde, Keri Martinowich, Stephanie C Hicks and Vincent […]

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ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts

Posted by dbos October 18, 2024October 28, 2024Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Caleb C. Reagor and A. J. Hudspeth | Summary: Like the sensory organs of the human inner ear, the lateral-line neuromasts (NMs) of fish such as the zebrafish (Danio rerio) contain mechanosensory hair cells (HCs) that are surrounded by progenitors called supporting cells. Damaged NMs can quickly regenerate […]

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Gut bacteria-derived succinate induces enteric nervous system regeneration

Posted by dbos October 18, 2024October 28, 2024Rockefeller

Kavli Affiliate: Daniel Mucida | Authors: Begüm Aydin, Izabela Mamede, Joana Cardoso, Julia Deere, Yelina Alvarez, Shanshan Qiao, Ved P. Sharma, Marissa A. Scavuzzo, Gregory P. Donaldson, Chun-Jun Guo and Daniel Mucida | Summary: Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion. Disruptions in microbial communities caused by antibiotics or enteric […]

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