The Spectroscopic Stage-5 Experiment

Kavli Affiliate: Joshua Frieman | First 5 Authors: Robert Besuner, Arjun Dey, Alex Drlica-Wagner, Haruki Ebina, Guillermo Fernandez Moroni | Summary: Observational cosmology has provided an extraordinary perspective on our universe and our place within it. However, as our understanding of the universe has increased, some glaring holes in our knowledge have become apparent: What […]


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Direct Detection of Ultralight Dark Matter via Charged Lepton Flavor Violation

Kavli Affiliate: Gordan Krnjaic | First 5 Authors: Innes Bigaran, Patrick J. Fox, Yann Gouttenoire, Roni Harnik, Gordan Krnjaic | Summary: We propose a dark matter direct-detection strategy using charged particle decays at accelerator-based experiments. If ultralight $(m_phi ll text{eV})$ dark matter has a misalignment abundance, its local field oscillates in time at a frequency […]


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Illuminating the Physics of Dark Energy with the Discovery Simulations

Kavli Affiliate: Katrin Heitmann | First 5 Authors: Gillian D. Beltz-Mohrmann, Adrian Pope, Alex Alarcon, Michael Buehlmann, Nicholas Frontiere | Summary: In this paper, we present the Discovery simulations: a new pair of high-resolution N-body simulations motivated by the DESI Y1 BAO cosmological constraints on dark energy. The Discovery simulations were run with identical initial […]


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High-Precision Transformer-Based Visual Servoing for Humanoid Robots in Aligning Tiny Objects

Kavli Affiliate: Wei Gao | First 5 Authors: Jialong Xue, Wei Gao, Yu Wang, Chao Ji, Dongdong Zhao | Summary: High-precision tiny object alignment remains a common and critical challenge for humanoid robots in real-world. To address this problem, this paper proposes a vision-based framework for precisely estimating and controlling the relative position between a […]


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The Stochastic Siren: Astrophysical Gravitational-Wave Background Measurements of the Hubble Constant

Kavli Affiliate: Daniel E. Holz | First 5 Authors: Bryce Cousins, Kristen Schumacher, Adrian Ka-Wai Chung, Colm Talbot, Thomas Callister | Summary: Gravitational waves from individually resolved compact object mergers can be used as standard sirens, offering a novel self-calibrating precision probe of cosmology. While the standard siren method has been well-explored, the gravitational-wave background […]


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Mapping the merging zone of late infall in the AB Aur planet-forming system

Kavli Affiliate: Ruobing Dong | First 5 Authors: Jessica Speedie, Ruobing Dong, Richard Teague, Dominique Segura-Cox, Jaime E. Pineda | Summary: Late infall events challenge the traditional view that planet formation occurs without external influence. Here we present deep ALMA $^{12}$CO $J=2-1$ and SO $J_{N}=5_6-4_5$ observations toward AB Aurigae, a Class II disk system with […]


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Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics

Kavli Affiliate: Peter Walter | Authors: Kristof Torkenczy, Lucas C Reineke, Sean W Dooling, Benjamin W Henderson, Daniel Itzhak, Benjamin Yang, Dongze He, Richard M Myers, Peter Walter, Stefka Tyanova and Mauro Costa-Mattioli | Summary: Persistent activation of the integrated stress response (ISR) is a major driver of cognitive decline in both neurodevelopmental and neurodegenerative […]


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ATMO: An Aerially Transforming Morphobot for Dynamic Ground-Aerial Transition

Kavli Affiliate: Morteza Gharib | First 5 Authors: Ioannis Mandralis, Reza Nemovi, Alireza Ramezani, Richard M. Murray, Morteza Gharib | Summary: Designing ground-aerial robots is challenging due to the increased actuation requirements which can lead to added weight and reduced locomotion efficiency. Morphobots mitigate this by combining actuators into multi-functional groups and leveraging ground transformation […]


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Deconvolution to restore cryo-EM maps with anisotropic resolution

Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]


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Development of an image-guided non-vitrectomy subretinal access approach for trans-scleral cell and gene therapy delivery

Kavli Affiliate: Jin Kang | Authors: Mandeep S Singh, Shoujing Guo, Christopher B Toomey, Minda M McNally, Sarah Harris-Bookman, Kang V Li, Dzhalal Agakishiev, Shuwen Wei, Soohyun Lee, Kathleen Perrino, Kevin C Wolfe and Jin Kang | Summary: Purpose Regenerative therapies for retinal diseases include cell and gene therapy modalities that are targeted to the […]


Continue.. Development of an image-guided non-vitrectomy subretinal access approach for trans-scleral cell and gene therapy delivery