Dopamine release effects on striatal blood oxygenation and whole brain plasticity underlying associative learning

Posted by dbos Columbia

Kavli Affiliate: Darcy Peterka | Authors: Amir Lawen, Isabella K Succi, Daniela Lichtman, Darcy S Peterka, Ishmail J Abdus-Saboor and Itamar Kahn | Summary: Dopaminergic signaling in the nucleus accumbens (NAc) is central to reward-based learning, but its relationship to brain-wide hemodynamics remains unclear. Using concurrent fMRI and dopamine photometry in awake, behaving mice, we […]


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Precision functional mapping reveals less inter-individual variability in the child vs. adult human brain

Posted by dbos UCSD / Salk

Kavli Affiliate: Deanna J. Greene | Authors: Damion V Demeter, Matthew Feigelis, Carolina Badke DAndrea, Sana A Ali, Abigail R Baim, Emily Koithan, Jared Stearns, Salma Zreik, Jonathan Ahern, Sujin Park, Sarah E Chang, Ryland L Miller, Jaqueline M Hampton, Bradley L Schlaggar, Scott Marek, Evan M Gordon, Nico UF Dosenbach, Caterina Gratton and Deanna […]


Continue.. Precision functional mapping reveals less inter-individual variability in the child vs. adult human brain

Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory.

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Shana E Silverstein, Thomas T Clarity, Meena S Deshpande, Erik Vaughan, Shoshana Novik, Hector E Yarur, Shiliang Zhang, Valerie S Tsai, Rong Ye, Rachel M Mikofsky, Madeline Hsiang, Avery Bauman, Gabriel Loewinger, Francisco Pereira, Marisela Morales, Vikaas S Sohal, Hugo Tejeda, Joshua A Gordon and David A Kupferschmidt | […]


Continue.. Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory.

Neural representation of action symbols in primate frontal cortex

Posted by dbos Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Lucas Y Tian, Kedar U Garzón, Adam G Rouse, Mark AG Eldridge, Marc H Schieber, Xiao-Jing Wang, Joshua B Tenenbaum and Winrich A Freiwald | Summary: At the core of intelligence is proficiency in solving new problems, including those that differ dramatically from problems seen before. Problem-solving, in turn, […]


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Goal Uncertainty Attenuates Sensorimotor Adaptation

Posted by dbos Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Sritej Padmanabhan, Reza S Shadmehr, Roberta Klatzky and Jonathan S Tsay | Summary: Implicit sensorimotor adaptation—the automatic correction of movement errors through feedback and practice—is driven by a perceptual prediction error, the mismatch between the perceived movement outcome and its intended goal. While perceptual uncertainty is known to attenuate […]


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Blood-tumor barrier organoids recapitulate glioblastoma microenvironment and enable high-throughput modeling of therapeutic delivery

Posted by dbos Columbia

Kavli Affiliate: Wei Min | Authors: Pei Zhuang, Benjamin Scott, Shuai Gao, Wei-Min Meng, Rui Yin, Xinyu Nie, Ludovica Gaiaschi, Sean E Lawler, Martine LM Lamfers, Fengfeng Bei and Choi-Fong Cho | Summary: The blood-brain barrier (BBB) is a highly specialized system that is critical for regulating transport between the blood and the central nervous […]


Continue.. Blood-tumor barrier organoids recapitulate glioblastoma microenvironment and enable high-throughput modeling of therapeutic delivery

Diet Processing and Nutrient Composition Drive Divergent Obesity Phenotypes in Wistar Rats

Posted by dbos UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Pedro Rocha Tenorio, Gabriel Smolak Sobieski e Silva, Débora Hipólito Quadreli, Glaura Scantamburlo Alves Fernandes and Fábio Goulart de Andrade | Summary: Purpose This study aimed to investigate whether food processing, alone or combined with high-fat/high-sugar content, promotes obesity, metabolic syndrome (MtS), and oxidative stress in adult rats. Methods […]


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Mouse pups lacking a cerebral cortex develop abnormal vocal behavior

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: J. Lomax Boyd, Cesar Vargas and Erich D. Jarvis | Summary: Vocal learning is an essential component of spoken language and critically depends on the cerebral cortex. The evolutionary origins of cortical/pallial control over vocal learning abilities in mammals and songbirds remains largely unknown. For instance, reports conflict on […]


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Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

Posted by dbos UCSF

Kavli Affiliate: Tejal Desai | Authors: Qinghe Zeng, Landon Flemming, Yuanzhou Chen, Thomas Mazumder, Heinz Hammerlindl, Greg M. Allen, Ricardo Almeida, Jasper Z. Williams, Rogelio A. Hernandez-Lopez, Justin Eyquem, Chun Jimmie Ye, Wendell A Lim, Qizhi Tang, Tejal Desai and Xiao Huang | Summary: T cell proliferative capacity and persistence critically determine the therapeutic success […]


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Increased Exertion Variability is Linked to Disruptions in Effort Assessment in Multiple Sclerosis

Posted by dbos Hopkins

Kavli Affiliate: Vikram Chib | Authors: Michael H Dryzer, Bardia Nourbakhsh, Jennifer Keller and Vikram S. Chib | Summary: Accurate assessment of exertion is crucial for determining whether to continue or rest during physical activity. Individuals with multiple sclerosis (MS) often report fatigue and motor impairments, yet the mechanisms underlying their assessments of effortful exertion […]


Continue.. Increased Exertion Variability is Linked to Disruptions in Effort Assessment in Multiple Sclerosis