Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering

Posted by dbos UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Simone D’Ambrogio, Jan Grohn, Nima Khalighinejad, Marcelo Mattar, Laurence T Hunt and Matthew F Rushworth | Summary: It has been suggested that humans and other animals are driven by a fundamental desire to acquire information about opportunities available in their environments. Not only might such a desire explain pathological […]


Continue.. Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering

SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Posted by dbos Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Sai Koukuntla, Tate DeWeese, Alexandra Cheng, Robyn Mildren, Aamna Lawrence, Austin R Graves, Jennifer Colonell, Timothy D Harris and Adam S Charles | Summary: The growing channel count of silicon probes has substantially increased the number of neurons recorded in electrophysiology (ephys) experiments, rendering traditional manual spike sorting […]


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Immunoinformatics Approach to Engineer a Multi-Epitope Vaccine Against SdrG in Skin Commensal Staphylococcus epidermidis

Posted by dbos UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Shahina Akter, Gabriel Vinícius Rolim Silva, Jonas Ivan Nobre Oliveira, Umberto Laino Fulco, Xianyang Xu and Yu Vincent Fu | Summary: The human skin serves as a dynamic ecosystem for beneficial commensal bacteria such as Staphylococcus epidermidis, which play a crucial role in maintaining skin barrier integrity and modulating […]


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Single Cell Proteomics in the Developing Human Brain

Posted by dbos UCSF

Kavli Affiliate: Arnold R. Kriegstein | Authors: Tianzhi Wu, lihua jiang, Tanzila Mukhtar, Li Wang, ruiqi jian, Cheng Wang, Tiffany Trinh, Arnold Kriegstein, Michael Snyder and Jingjing Li | Summary: Proteins are the functional effectors of virtually all biological processes, and accurately measuring their abundance and dynamics is essential for understanding development and disease. Although […]


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The DECam MAGIC Survey: Spectroscopic Follow-up of the Most Metal-Poor Stars in the Distant Milky Way Halo

Posted by dbos Chicago

Kavli Affiliate: Alexander P. Ji | First 5 Authors: Vinicius M. Placco, Guilherme Limberg, Anirudh Chiti, Deepthi S. Prabhu, Alexander P. Ji | Summary: In this work, we present high-resolution spectroscopic observations for six metal-poor stars with [Fe/H]<-3 (including one with [Fe/H]<-4), selected using narrow-band Ca II HK photometry from the DECam MAGIC Survey. The […]


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Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: The global rise in human allergic and autoimmune diseases is linked to altered environmental microbiome exposures from increasing […]


Continue.. Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Posted by dbos NTNU

Kavli Affiliate: Valentina Di Maria | Authors: Daniel P. Moore, Heather B. Steele-Stallard, Luca Pinton, Valentina Maria Lionello, Lucia Rossi, Artadokht Aghaeipour, Salma Jalal, Cherry Tsz Yan Wong, Angela Clara-Hwang, Gisèle Bonne, Peter S. Zammit and Francesco Saverio Tedesco | Summary: LMNA-related congenital muscular dystrophy (L-CMD) is amongst the most severe forms of laminopathies, which […]


Continue.. Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]


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Predicting the Evolutionary and Functional Landscapes of Viruses with a Unified Nucleotide-Protein Language Model: LucaVirus

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Yuan-Fei Pan, Yong He, Yu-Qi Liu, Yong-Tao Shan, Shu-Ning Liu, Xue Liu, Xiaoyun Pan, Yinqi Bai, Zan Xu, Zheng Wang, Jieping Ye, Edward C. Holmes, Bo Li, Yao-Qing Chen, Zhao-Rong Li and Mang Shi | Summary: Predicting the evolution and function of viruses is a fundamental biological challenge, largely […]


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Experimental realization of the bucket-brigade quantum random access memory

Posted by dbos Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Fanhao Shen, Yujie Ji, Debin Xiang, Yanzhe Wang, Ke Wang | Summary: Quantum random access memory (QRAM) enables efficient classical data access for quantum computers — a prerequisite for many quantum algorithms to achieve quantum speedup. Despite various proposals, the experimental realization of QRAM remains largely unexplored. […]


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