Kavli Affiliate: Erich Jarvis | Authors: Jonathan Fenn, Jessica C Edge, Vladimir Ovchinnikov, Olga Amelkina, Melea Sinclair, Tiago H C De Bem, Alessandra Bridi, Irene Malo-Estepa, Angela Gonella-Diaza, Felipe Perecin, Juliano C da Silveira, Guilherme Pugliesi, Flavio Vieira Meirelles, Zenab Butt, Haidee Tinning, Giulio Formenti, Erich Jarvis, Bastian Fromm, James O McInerney, Niamh Forde and […]
Kavli Affiliate: Bjoern Schwer | Authors: Joseph A Stewart, Jeanmarie Mishler, Samreen Ahmed, Bjoern Schwer, Thomas W. Glover and Thomas E Wilson | Summary: High-fidelity detection of rare structural variants (SVs) remains challenging because library preparation and sequencing techniques generate artifactual junctions that obscure true single-molecule events. Here, we present HiFiRe3, an error-minimized sequencing framework […]
Kavli Affiliate: Vikram Chib | Authors: Naser Al-Fawakhiri, Vikram S. Chib and Samuel D. McDougle | Summary: Multiple learning signals can shape motor output, including reward and punishment (via value-based reinforcement learning) and sensorimotor error (via motor adaptation). However, it is unclear if action values, learned via reinforcement learning, interact with error-based motor learning. Here, […]
Kavli Affiliate: Pietro De Camilli | Authors: Yumei Wu, Peng Xu, James Moran, C. Shan Xu, Kenneth J. Hayworth, Mian Cao, Lin Shao, D. James Surmeier, Harald F. Hess and Pietro De Camilli | Summary: Synaptojanin 1 is a brain enriched phosphoinositide phosphatase implicated in endocytosis at the synapse. A mutation (R258Q) that selectively impairs […]
Kavli Affiliate: Wei Min | Authors: Alexander-Hoi Nguyen, Vicky Li, Wei-Min Chen, Jacob Kimberg, Anthony J. Davis, David G. McFadden and Juan Manuel Povedano | Summary: DNA mismatch repair (MMR) deficiency has been widely utilized in forward genetic screens to identify drug resistance mutations and elucidate the mechanisms of action of cytotoxic small molecules. However, […]
Kavli Affiliate: Alexandra Nelson | Authors: Emily L Twedell, Chloe J Bair-Marshall, Allison E Girasole, Lara K Scaria, Sadhana Sridhar and Alexandra B Nelson | Summary: Striatal medium spiny neurons (MSNs) integrate convergent cortical, thalamic, and dopaminergic inputs to shape motor output. In addition, MSNs form local inhibitory synaptic connections with one another. The function […]
Kavli Affiliate: Mark Ellisman | Authors: Zhaoqi Yan, Andrew S Mendiola, Kelli Lauderdale, Keun-Young Kim, Yu Yong, Kun Leng, Eric A Bushong, Renaud Schuck, Anke Meyer-Franke, Ayushi Agrawal, Michela Traglia, Natalie Gill, Reuben Thomas, Jonah N Keller, Nikolaos Karvelas, Miguel F Vasquez, Daniel C Ballard, Matthew Madany, Jeffrey Simms, Brandon Guo, Reshmi Tognatta, Maria del […]
Kavli Affiliate: Gabriel Silva | Authors: Pedro Rocha Tenorio, Gabriel Smolak Sobieski e Silva, Isadora Chagas Vercellone, Débora Hipólito Quadreli, Juliany Carolina Duma de Castro, Glaura Scantamburlo Alves Fernandes and Fábio Goulart de Andrade | Summary: While obesity is widely recognized as a global epidemic, the specific roles of food processing and macronutrient composition in […]
Kavli Affiliate: Yifan Cheng | Authors: Makoto Nakamura, Xiaoxin Chen, Shun Yao, Lynette Xin Chan, Ruan Hongmei, Alexis Boulinguiez, Nav Lally, Hao Wu, Kara Kodani, Kentaro Hirose, James Pirruccello, Alberto Malerba, Yifan Cheng, Vasanth Vedantham, Longzhi Tan, Jeffrey E. Olgin, Di Lang and Guo N. Huang | Summary: Three-dimensional genome organization stabilizes cell-type-specific gene expression, […]
Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Dominic E. Absolon, Linelle Ann L. Abueg, Francine Ackerman, Farooq Omar Al-Ajli, Alexandre Aleixo, Agostinho Antunes, Dahiana Arcila, Jean-Nicolas Audet, Jennifer R. Balacco, Alan James Stephen Beavan, Katherine Belov, Ricardo Betancur-R., Shelby L Bidwell, Matthew T Biegler, Iliana Bista, Mark Blaxter, Kevin Boyer, Ingo Braasch, Ian R […]