Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation

Posted by dbos UCSD / Salk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Angela Yu | Authors: Samantha E. Koplik, Angela M Yu, Madelyn R. Shelby, Gabriel C. Fonseca, Charles M. Roco, Yue Zhang, Nicholas Bogard, Alex K. Sabo, Alexander B. Rosenberg, Johannes Linder and Georg Seelig | Summary: Splice-disrupting variants (SDVs) underlie […]


Continue.. Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation

Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen

Posted by dbos Rockefeller

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Alexander J Stuart, Kaori Takai, Railia R. Gabbasova, Henry Sanford, Ekaterina V. Vinogradova and Titia de Lange | Summary: Replicative senescence, a powerful tumor suppressor pathway, occurs when a few critically-short telomeres activate the DNA […]


Continue.. Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen

Uncertainty-Gated Min-Cost Flows for In Vivo NanoScale Synaptic Plasticity Tracking

Posted by dbos Hopkins

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Richard Huganir, Adam S. Charles and Michael Miller | Authors: Shashwat Kumar, Gabrielle I Coste, Dasun Premathilaka, Richard L. Huganir, Austin R Graves, Adam S Charles and Michael I Miller | Summary: Synapses are the fundamental unit of neural connectivity. […]


Continue.. Uncertainty-Gated Min-Cost Flows for In Vivo NanoScale Synaptic Plasticity Tracking

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury

Posted by dbos Columbia

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Elizabeth Hillman | Authors: Mary Claire Tuohy, Ping-Chang Kuo, Adrian Chelminski, Eti Muharremi, Claudia DeSantis, Aomeng Cui, Alicia Russo, Danny Jamoul, Elizabeth Hillman, John F Crary, Jui-Hung Jimmy Yen and Dritan Agalliu | Summary: Vascular normalization [stabilization of aberrant angiogenesis […]


Continue.. Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury

Rearing condition affects behavioral response to cross-modal expectancy violation paradigm in zebra finche

Posted by dbos Columbia

Kavli Affiliate: Sarah Woolley | Authors: Isabella Catalano and Sarah Cushing Woolley | Summary: Interacting in a multimodal world, including recognizing other individuals across multiple sensory modalities, is important for animals who rely on social relationships for survival. Social and sensory experiences shape how multisensory information is processed and integrated; however, we have less understanding […]


Continue.. Rearing condition affects behavioral response to cross-modal expectancy violation paradigm in zebra finche

Astrocyte SEMA3C reduction improves Rett Syndrome phenotypes

Posted by dbos UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: Krissy A Lyon, Adrien Paumier, Ananya Kandikonda, Andrea Melendez and Nicola J Allen | Summary: During typical neurodevelopment, astrocytes secrete proteins that support neuronal connectivity. This process is disrupted in Rett Syndrome (RTT), a regressive neurodevelopmental disorder characterized by motor, sensory, and cognitive impairments. While astrocytes typically promote neuron […]


Continue.. Astrocyte SEMA3C reduction improves Rett Syndrome phenotypes

Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells

Posted by dbos Hopkins

Kavli Affiliate: James Knierim | Authors: Ravikrishnan P Jayakumar, Yotaro Sueoka, Marissa K Ferreyros, Brian Y Li, Manu S Madhav, Xingyu Chen, James J Knierim and Noah J Cowan | Summary: Accurate spatial navigation relies on path integration, a process of tracking one’s location by integrating self-motion cues. Path integration uses a gain factor relating […]


Continue.. Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells

Sensorimotor Theta Oscillations Coordinate Speech Movements

Posted by dbos UCSF

Kavli Affiliate: Edward Chang and Loren Frank | Authors: Yitzhak Norman, Loren M. Frank and Edward F. Chang | Summary: Fluent speech depends on precisely timed motor commands that coordinate rapid transitions between successive articulatory gestures. Using direct cortical recordings, we identified a prominent sensorimotor theta oscillation (6–10 Hz) that supports this coordination. During articulation, […]


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Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

Posted by dbos Hopkins

Kavli Affiliate: Jeremy Nathans | Authors: Yanshu Wang, Amir Rattner, Zhongming Li, Philip M Smallwood and Jeremy Nathans | Summary: In mice, postnatal endothelial cell (EC)-specific knockout of the genes coding for Transforming Growth Factor-Beta Receptor (TGFBR)1 and/or TGFBR2 eliminates TGF-beta signaling in vascular ECs and leads to distinctive central nervous system (CNS) vascular phenotypes. […]


Continue.. Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

Ingestion-activated CGRP neurons control learning but not satiety

Posted by dbos UCSF

Kavli Affiliate: Zachary Knight | Authors: Brooke C Jarvie, Anagh Ravi, Rhea Nanavati, Longhui Qui, Truong Ly, Jun Y Oh, Olivia K Barnhill and Zachary A Knight | Summary: Calcitonin Gene-Related Peptide (CGRP) neurons in the parabrachial nucleus are critical for sickness and malaise but have also been proposed to control non-aversive (rewarding) satiation. How […]


Continue.. Ingestion-activated CGRP neurons control learning but not satiety