Photon-Resolved Excitation-Denoised (PRED) Three-Photon Imaging Improves Detection of Neuronal Activity in Awake and Behaving Mice

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Attila Losonczy and Darcy Peterka | Authors: Attila Losonczy, Tiberiu S Mihaila, Eunji Kong, Adrian Negrean, Tristan Geiller and Darcy S Peterka | Summary: Three-photon microscopy (3PM) has enabled the optical access of neurons ∼500-1500µm below the brain surface but has been limited to slow imaging frame rates or small imaged area due […]


Continue.. Photon-Resolved Excitation-Denoised (PRED) Three-Photon Imaging Improves Detection of Neuronal Activity in Awake and Behaving Mice

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Keri Martinowich | Authors: Sang Ho Kwon, Boyi Guo, Cindy Fang, Madhavi Tippani, Svitlana V Bach, Ryan A Miller, Sarah E Maguire, Artemis Iatrou, Geo Pertea, Nicholas J Eagles, Madeline R Valentine, Seyun Oh, Aarti Jajoo, Vijetha Balakundi, Yufeng Du, Annie B Nguyen, Ruth Zhang, Uma M Kaipa, Heena R Divecha, Jashandeep S. […]


Continue.. Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

Spatial Regulation of CAR Signaling Enables Logic-Gated Activity

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Denis Wirtz | Authors: Tushar D Nichakawade, Brian Mog, Alexander D Pearlman, Taha S. Ahmedna, Nikita Marcou, Ricardo Mora-Cartin, Evangeline Watson, Bum Seok Lee, Sarah R. DiNapoli, Nickolas Papadopoulos, Chetan Bettegowda, Marco Dal Molin, Denis Wirtz, Drew M. Pardoll, Suman Paul, Surojit Sur, Kathleen L. Gabrielson, Shibin Zhou, Bert Vogelstein and Kenneth W. […]


Continue.. Spatial Regulation of CAR Signaling Enables Logic-Gated Activity

Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Richard Huganir | Authors: Sohum Mehta, Nidhi A. Thaker, Kengo Adachi, Christopher Y. Ko, Bian Liu, Sai S. Divkaruni, Oguz C. Koc, Anne C. Lyons, Samantha A. Sanchez, Pauline Löffler, Yoshihisa Nakahata, Jody L. Martin, Jared L. Johnson, Tomer M. Yaron-Barir, Lewis C. Cantley, Martin J. Lohse, Andreas Bock, Donald M. Bers, Ryohei […]


Continue.. Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors

Nonlinear Wave Propagation in 1D Polycatenated Ring Chains

Posted by klaurent Caltech, This Week: Nanoscience

Kavli Affiliate: Chiara Daraio | Summary:We study the nonlinear wave dynamics of one-dimensional chains of polycatenated rings. These interlocked structures support amplitude-dependent nonlinear wave propagation driven by tensile activation and internal structural flexibility, unlike traditional granular crystals. Through dynamic impact experiments, finite-element modeling, and discrete-particle simulations of vertical chains pretensioned by gravity, we observe and […]


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Unlocking Proactivity in Task-Oriented Dialogue

Posted by klaurent Caltech, This Week: Nanoscience

Kavli Affiliate: Wei Gao| Summary:Proactive task-oriented dialogue (TOD), such as outbound sales, demands a persuasive agent that actively probes the user’s concerns and steers the conversation toward acceptance within a bounded number of turns. Yet post-trained LLMs are inherently conservative, and reward-shaping RL (e.g., GRPO) struggles since it only re-weights what an already passive policy […]


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Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Lily Jan and Yuh Nung Jan | Authors: Jing Hui Adeline J. H. Yong, Yuh Nung Jan, Yayu Wang, Juan A Oses-Prieto, Tong Cheng, Chao Chen, Mario V Zubia, Alma Burlingame, Lily Y Jan, Nicholas T Ingolia and J. Wren Kim | Summary: Synapses are dynamic structures whose protein composition remodels in response […]


Continue.. Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

Optics-microwave entanglement and state teleportation mediated by a cavity magnomechanical system

Posted by klaurent Delft, This Week: Nanoscience

Kavli Affiliate: Ya Blanter | Summary:Generating usable output-entanglement in continuous variable systems can serve as a viable resource for improving applications in quantum information science. In this work, we show how to generate steady-state output-entanglement in a two-stage conversion setup between optical and microwave photon which employs resonantly coupled magnetic and mechanical excitations, as proposed […]


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Stacking-order-dependent electronic properties of MoTe2/WSe2 moiré bilayers

Posted by klaurent Cornell, This Week: Nanoscience

Kavli Affiliate: David Muller | Summary:Transition metal dichalcogenide (TMD) moiré bilayers have realized a wide range of strongly correlated and topological phenomena. The physics in these materials is often sensitive to the interlayer stacking order. Polarization-resolved optical second harmonic generation (SHG) is the most used technique for stacking order characterization but unverified for most heterobilayers. […]


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Federated LoRA Fine-Tuning for LLMs via Collaborative Alignment

Posted by klaurent Peking, This Week: Astrophysics

Kavli Affiliate: Feng Long| Summary: Low-rank adaptation (LoRA) has emerged as a powerful tool for parameter-efficient fine-tuning of large language models (LLMs). This paper studies LoRA under a federated learning setting, enabling collaborative fine-tuning across clients while preserving parameter efficiency. We focus on a highly heterogeneous regime in which clients share only partial structure and […]


Continue.. Federated LoRA Fine-Tuning for LLMs via Collaborative Alignment