Robust volumetric multiplex staining of centimeter-scale FFPE tissues guided by neural network-based optimization

Posted by dbos UCSD / Salk

Kavli Affiliate: Ann-Shyn Chiang | Authors: Ya-Hui Lin, Chao-Yin Huang, Yin-Hsu Chen, Yen-Hui Chen, Zhe-Wei Xu, Ping-Liang Ko, Heng-Hua Hsu, Yi-Chung Tung, Yu-Fang Chen, Hui-Chi Chen, Ann-Shyn Chiang, Kimberly L Fiock, Kuo-Chuan Wang, Chin-Hsien Lin, Shang-Hsiu Hu, Bi-Chang Chen and Li-An Chu | Summary: Neurodegenerative diseases involve structural and morphological alterations in tissue architecture that […]


Continue.. Robust volumetric multiplex staining of centimeter-scale FFPE tissues guided by neural network-based optimization

Saxiphilin is a broad-spectrum toxin sponge for C13-modified saxitoxins

Posted by dbos UCSF

Kavli Affiliate: Daniel Minor | Authors: Sandra Zakrzewska, Zhou Chen, Elizabeth Park, Roshni G Bhaskar, T. Aaron Bedell, J Du Bois and Daniel L Minor, Jr. | Summary: Saxitoxin (STX) and its congeners (paralytic shellfish toxins, PSTs) are among the most potent small-molecule toxins. PSTs are produced by harmful algal blooms and derive toxicity by […]


Continue.. Saxiphilin is a broad-spectrum toxin sponge for C13-modified saxitoxins

Exploring Links between Brain Image-Derived Phenotypes and Accelerometer-Measured Physical Activity in the UK Biobank

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist and Ciprian Crainiceanu | Authors: Ahmad B. Taha, Seong Yeol An, Su-Jeong Kim, Rowhan Daly, Jeremiah Y. Cohen and Solange P. Brown | Summary: A broad range of neurodegenerative disorders are associated with altered functional connectivity (FC) patterns and atrophy of gray matter volume (GMV). Similarly, there are links between physical […]


Continue.. Exploring Links between Brain Image-Derived Phenotypes and Accelerometer-Measured Physical Activity in the UK Biobank

Cell-type-specific sustained value representations in the claustrum

Posted by dbos Hopkins

Kavli Affiliate: Solange Brown and Jeremiah Cohen | Authors: Ahmad B. Taha, Seong Yeol An, Su-Jeong Kim, Rowhan Daly, Jeremiah Y. Cohen and Solange P. Brown | Summary: Flexible decision-making relies on interactions between frontal cortex and subcortical structures. The claustrum, a subcortical nucleus highly interconnected with frontal cortex, influences cortical activity and has been […]


Continue.. Cell-type-specific sustained value representations in the claustrum

Toroidal topology of grid-cell activity precedes spatial navigation during development

Posted by dbos NTNU

Kavli Affiliate: Edvard Moser and May-Britt Moser | Authors: Matteo Guardamagna, Erik Hermansen, Jordan Carpenter, Christine Marie Lykken, Benjamin Adric Dunn, Edvard Ingjald Moser and May-Britt Moser | Summary: The medial entorhinal cortex (MEC) is a central component of the mammalian navigation system1–5, in which spatially and directionally tuned neurons, including grid cells and head-direction […]


Continue.. Toroidal topology of grid-cell activity precedes spatial navigation during development

Pattern stability in reaction-diffusion systems depends on path entropy

Posted by klaurent Berkeley

Kavli Affiliate: David T. Limmer | Summary:Reaction-diffusion systems driven far from thermodynamic equilibrium through the injection of energy can support multiple distinct spatial patterns that persist as long-lived dynamical phases. The stability of these metastable phases is not determined by thermodynamics, but by the transition paths connecting them. At finite particle numbers, intrinsic stochasticity induces […]


Continue.. Pattern stability in reaction-diffusion systems depends on path entropy

A systematic study of AGN feedback in a disk galaxy I: global overview

Posted by klaurent Peking

Kavli Affiliate: Luis Ho | Summary:This is the first paper in a series using our MACER framework to investigate the evolution of a disk galaxy, which emphasizes the role of active galactic nucleus (AGN) feedback and incorporates cosmological inflows. This paper presents the model setup and the overall results. The predicted AGN duty cycle of […]


Continue.. A systematic study of AGN feedback in a disk galaxy I: global overview

Can electronic quantum criticality drive phonon-induced linear-in-temperature resistivity?

Posted by klaurent Cornell

Kavli Affiliate: Debanjan Chowdhury | Summary:Optical phonons naturally generate linear-in-$T$ resistivity in the high-temperature equipartition regime, but their finite gap prevents this mechanism from surviving to asymptotically low temperatures. Here we analyze whether proximity to an electronic quantum critical point can remove this obstruction by strongly softening an optical phonon. We first derive a model-independent […]


Continue.. Can electronic quantum criticality drive phonon-induced linear-in-temperature resistivity?

Can electronic quantum criticality drive phonon-induced linear-in-temperature resistivity?

Posted by klaurent Cornell

Kavli Affiliate: Debanjan Chowdhury | Summary:Optical phonons naturally generate linear-in-$T$ resistivity in the high-temperature equipartition regime, but their finite gap prevents this mechanism from surviving to asymptotically low temperatures. Here we analyze whether proximity to an electronic quantum critical point can remove this obstruction by strongly softening an optical phonon. We first derive a model-independent […]


Continue.. Can electronic quantum criticality drive phonon-induced linear-in-temperature resistivity?

FlowSN: Neural Simulation-Based Inference under Realistic Selection Effects applied to Supernova Cosmology

Posted by klaurent Cambridge

Kavli Affiliate: Kaisey Mandel | Summary:We present FlowSN, a statistical framework using simulation-based inference (SBI) with normalising flows to account for selection effects in observational astronomy. Failure to account for selection effects can lead to biased inference on global parameters. An example is Malmquist bias, where detection limits result in a sample skewed towards brighter […]


Continue.. FlowSN: Neural Simulation-Based Inference under Realistic Selection Effects applied to Supernova Cosmology