Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number

Posted by dbos Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Jason Manley, Jefferey Demas, Hyewon Kim, Francisca Martinez Traub and Alipasha Vaziri | Summary: The brain’s remarkable properties arise from collective activity of millions of neurons. Widespread application of dimensionality reduction to multi-neuron recordings implies that neural dynamics can be approximated by low-dimensional “latent” signals reflecting neural computations. However, […]


Continue.. Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number

RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao | Authors: mengya Zhao, Beiying Dai, Xiaodong Li, Yixin Zhang, Chun Qiao, Yaru Qin, Zhao Li, Qingmei Li, Shuzhen Wang, Yong Yang and Yijun Chen | Summary: Philadelphia chromosome-positive (Ph+) leukemia is a fatal hematological malignancy. Although standard treatments with tyrosine kinase inhibitors (TKI) have achieved remarkable success in prolonging patient […]


Continue.. RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia

The control of overt and covert attention across two nodes of the attention-control network

Posted by dbos Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Pablo Polosecki, Sara C Steenrod, Heiko Stemmann and Winrich A. Freiwald | Summary: Attention is a central cognitive capability whose focus is thought to be directed by a spatial map coding behavioral priority. Here we tested the three defining properties of priority map theory with electrophysiological recordings from two […]


Continue.. The control of overt and covert attention across two nodes of the attention-control network

The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Deanna Arsala, Shengqian Xia, Cong Li, Mujahid Ali, Nicolas Svetec, Christopher Langer, Debora Sobreira, Ittai Eres, Dylan Sosa, Jianhai Chen, Li Zhang, Patrick Reilly, Alexander Guzzetta, J.J. Emerson, Peter Andolfatto, Li Zhao and Manyuan Long | Summary: Previous evolutionary models of duplicate gene evolution have overlooked the […]


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Pronounced early differentiation underlies zebra finch gonadal germ cell development

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | First 5 Authors: Matthew T Biegler, Kirubel Belay, Wei Wang, Christina Szi, Paul G Collier, Ji-Dung Luo, Bettina Haase, Gregory L. Gedman, Asha V. Sidhu, Elijah Harter, Carlos Rivera-Lopez, Kwame Amoako-Boadu, Olivier Fedrigo, Hagen U. Tilgner, Thomas T Carroll, Erich D. Jarvis and Anna L. Keyte | Summary: The diversity […]


Continue.. Pronounced early differentiation underlies zebra finch gonadal germ cell development

CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Isabel E Wassing, Atsuya Nishiyama, Moeri Hiruta, Qingyuan Jia, Reia Shikimachi, Amika Kikuchi, Keita Sugimura, Xin Hong, Yoshie Chiba, Junhui Peng, Christopher Jenness, Makoto Nakanishi, Li Zhao, Kyohei Arita and Hironori Funabiki | Summary: Mutations of the SNF2 family ATPase HELLS and its activator CDCA7 cause immunodeficiency-centromeric instability-facial anomalies […]


Continue.. CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Posted by dbos Rockefeller

Kavli Affiliate: Robert Edwards | Authors: R. Dilshan Malewana, Victoria Stalls, Aaron May, Xiaozhi Lu, David R Martinez, Alexandra Schafer, Dapeng Li, Maggie Barr, Laura L Sutherland, Esther Lee, Robert Parks, Whitney Edwards Beck, Amanda Newman, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, C. Todd DeMarco, Thomas N Denny, Thomas H Oguin III, Wes […]


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DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

Posted by dbos Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli | Authors: Mukesh Kumar, Yumei Wu, Justin Knapp, Daehun Park, Kallol Gupta, Pietro De Camilli and Timothy A. Ryan | Summary: HSP54, a hereditary spastic paraplegia associated with cognitive impairment, is caused by mutations in the neuron-specific triglyceride (TG) lipase DDHD2. Loss of DDHD2 function results […]


Continue.. DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

Covalent Targeting of Splicing in T Cells.

Posted by dbos Rockefeller

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab and Ekaterina V Vinogradova | Summary: Despite significant interest in therapeutic targeting of splicing, few chemical probes […]


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Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Posted by dbos Rockefeller, Yale

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community