Kavli Affiliate: Nathaniel Heintz | Authors: Alan Umfress, Patrick Wertimer, Christina Pressl, Matthew Baffuto, Kert Mätlik, Franchesca Fernandez, Maria Esterlita Siantoputri, Ines Ibañez-Tallon and Nathaniel Heintz | Summary: G Protein coupled receptors (GPCRs) are the largest class of clinically validated drug targets with nearly 35% of all approved therapeutic agents acting on these receptors. To […]

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Shanshan Liu, Mark Gad, Caifan Li, Kevin Cho, Yuyang Liu, Khando Wangdu, Viktor Belay, Alon Millet, Hiroyuki Kojima, Henry Sanford, Michele Wolk, Linas Urnavicius, Maria Fedorova, Gary J. Patti, Ekaterina V. Vinogradova, Richard K. Hite and Kivanc Birsoy | Summary: The endoplasmic reticulum (ER) requires an oxidative environment […]

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Hiroyuki Kojima, Charlotte R Wayne, Luis F. Somarribas Patterson, Henry Sanford, Tzu-Jou Chen, Ya-Hui Lin, Joshua D. Schoenfeld, Lisa H. F. McGary, Yan-Ting Chen, Korbinian N. Kropp, Beatrice Zhang, Jahan Rahman, Tiffany L. Zhang, Nathalie Ropek, Cameron Roberts, Yuxi Ai, Kartikeya Menon, A. Ari Hakimi, Jiankun Lyu, Christopher […]

Kavli Affiliate: Nathaniel Heintz | Authors: Chris Kay, Jessica Dawson, Kert Mätlik, Hailey Findlay Black, Emily Harvey, Stephanie Bortnick, Kyla Javier, Christina Buchanan, Tanu Soomarooah, Inês Caldeira Brás, Glen Sequiera, Mahmoud Pouladi, Larissa Arning, Hoa HP Nguyen, Richard Roxburgh, Maurice Curtis, Richard LM Faull, Nathaniel Heintz and Michael R Hayden | Summary: Synonymous loss of […]

Kavli Affiliate: Daniel Mucida | Authors: Roham Parsa, Helder Carvalho de Assis, Tiago B.R. de Castro, Gabriella Lima dos Reis, Arpita Sushil, Harald Hartweger, Angelina Bilate and Daniel Mucida | Summary: Pathogen-specific CD4⁺ T cells undergo dynamic expansion and contraction during infection, ultimately generating memory clones that shape the subsequent immune responses. However, the influence […]

Kavli Affiliate: Li Zhao | Authors: Yang Jiang, Xiaoyang Liu, Li Zhao and Zhong-Yuan Lu | Summary: Intrinsically disordered regions (IDRs) are pervasive in eukaryotic proteomes and play central roles in regulatory complexity and evolutionary innovation. While their conformational ensembles have been extensively characterized in isolation, most long IDRs function within multidomain proteins, where domain […]

Kavli Affiliate: Erich Jarvis | Authors: Tanya M Lama, Blair P Bentley, Warren E Johnson, Lisa M Komoroske, Stephen DeStefano, Jennifer Vashon, Kaela Beauclerc, Jason M Kamilar, Giulio Formenti, Andrea Batista, Andrew G Spencer, Olivier Federigo, Erich D Jarvis, Jeff S Bowman, Paul Wilson and John F Organ | Summary: Species must acclimate, shift their […]

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kivanc Birsoy, Shanshan Liu, Mark Gad, Caifan Li, Kevin Cho, Yuyang Liu, khando Wangdu, Victor Belay, Alon Millet, Hiroyuki Kojima, Henry Sanford, Michele Wolk, Linas Urnavicius, Maria Fedorova, Gary J. J. Patti, Ekaterina V Vinogradova and Richard K Hite | Summary: Grasslands, as one of the most important […]

Kavli Affiliate: Nathaniel Heintz | Authors: Bianca A Cotto, Lizi Zhang, Benjamin W Fait, Christopher Peralta, Ece Kilic, Henrik Molina, Nathaniel Heintz and Eric F Schmidt | Summary: Neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) exhibit striking cell-type selectivity, yet the basis for this vulnerability remains elusive. Here, we uncover that even closely related neurons […]

Kavli Affiliate: Daniel Mucida and Elaine Fuchs | Authors: Sara Martina Parigi, Sairaj Munavar Sajjath, Charlotte Jeanne Bell, Shaopeng Yuan, Vitoria Murakami Olyntho, Alain Robert Bonny, Sandra Nakandakari-Higa, Sergio Lira, Daniel Mucida, Gabriel D Victora and Elaine Fuchs | Summary: In adult tissues, epithelial stem cells exist within distinct residences, each endowing them with exclusive […]