Kavli Affiliate: Daniel Mucida | Authors: Patrick W Darcy, Vitoria M Olyntho, Albana Kodra, Zachary Kerner, Maria C.C. Canesso, Sandra Nakandakari-Higa, Gabriel Victora and Daniel Mucida | Summary: Food allergies are associated with progressive gastrointestinal symptoms driven by exacerbated mucosal type-2 immunity. Here, we investigated whether cellular interactions between the gut epithelium and innate immune […]

Kavli Affiliate: Charles M. Rice | Authors: Trinity Zang, Viren A Baharani, Miranda Aldis, Marie Canis, Rachel Patejak, Edmund Osei Kuffour, Hans Heinrich Hoffman, Harm van Bakel, Emilia M Sordillo, Viviana Simon, Margaret R MacDonald, Charles M Rice, Michel C Nussenzweig, Theodora Haziionannou and Paul D Bieniasz | Summary: A central problem in achieving vaccine-based […]

Kavli Affiliate: Winrich Freiwald and Alipasha Vaziri | Authors: Santiago Otero-Coronel, David Grant Colburn Hildebrand, Tobias Noebauer, Jeffrey Demas, Brandon Chen, Siegfried Weisenburger, Frank Tejera, Sverre Grodem, Kristian Kinden Lensjo, Guro Helen Vatne, Marianne Fyhn, Winrich A Freiwald and Alipasha Vaziri | Summary: Primate neocortex is organized into functionally defined domains. Understanding how the functional […]

Kavli Affiliate: Jean-Laurent Casanova | Authors: Colin Kim, Maira Gaballa, Danyel Lee, Emmanuelle Jouanguy, Shen-Ying Zhang, Jean-Laurent Casanova and Ahmad Yatim | Summary: The binding of transmembrane (TM) ligands to their cognate TM receptors on neighboring cells governs intercellular adhesion and direct cell–cell communication. However, these interactions are difficult to study in vitro because they […]

Kavli Affiliate: C. David Allis and Mary E. Hatten | Authors: Irma Laas, Matthew R Paul, Natarajan Bhanu, Lijuan Feng, Eve-Ellen Govek, Benjamin A Garcia, Thomas S Carroll, C David Allis, Mary E. Hatten and Kärt Mätlik | Summary: Neuronal maturation is associated with extensive changes in gene expression and chromatin organization. However, the molecular […]

Kavli Affiliate: A. James Hudspeth | Authors: Emily Atlas, Caleb C. Reagor, Brian Frost, Sapna Krishnakumar, A. J. Hudspeth and Adrian Jacobo | Summary: Cell-cell signaling and cell-fate decisions are essential for organ assembly, but how these molecular events translate into the physical properties and cell behaviors that drive development remains poorly understood. In the […]

Kavli Affiliate: Erich Jarvis | Authors: Chern-sing Goh, Matthew Davenport, Chul Lee and Erich Jarvis | Summary: Humans possess human-specific traits1,2 such as spoken language and lineage-specific traits such as ape-specific taillessness3,4. Previous efforts to identify the DNA sequences responsible for such human traits were limited by necessary accommodations for poor genome assembly quality and […]

Kavli Affiliate: Jeffrey M. Friedman | Authors: Zhaoyue Zhang, Alexandre Moura-Assis, Shanshan Liu, Alon Millet, Jordan Shaked, Divya Rajan, Hanan Alwaseem, Michael Isay-Del Viscio, Henrik Molina, Kivanc Birsoy and Jeffrey M. Friedman | Summary: While standard high fat diets cause hyperphagia and obesity in mice, high fat-low carbohydrate ketogenic diets (KDs) reduce food intake and […]

Kavli Affiliate: Erich Jarvis | Authors: Chul Lee, Matthew H Davenport and Erich D Jarvis | Summary: Human speech likely arose from regulatory changes for speech-related brain regions, yet causal variants and mechanisms remain unclear. RBFOX1 is a prime candidate, showing specialized expression in vocal learning circuits of human and zebra finch brains and carrying […]

Kavli Affiliate: Robert B. Darnell | Authors: Michael R. Mazzucco, Bella Mehta, Jenelys Ruiz-Ortiz, Caryn Hale, Fuadur Omi, Purva Singh, Ruoxi Yuan, Samantha Lessard, Eun Kyung Song, Mengrui Zhang, Shady Younis, William H. Robinson, Daniel Ramirez, Edward DiCarlo, Wei Wang, Thomas Carroll, Jose Rodriguez, Peter Sculco, Xiaoshun Li, YiYuan Wu, Robert B. Darnell, Martin Lotz, […]