Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli | Authors: Mukesh Kumar, Yumei Wu, Justin Knapp, Daehun Park, Kallol Gupta, Pietro De Camilli and Timothy A. Ryan | Summary: HSP54, a hereditary spastic paraplegia associated with cognitive impairment, is caused by mutations in the neuron-specific triglyceride (TG) lipase DDHD2. Loss of DDHD2 function results […]
Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab and Ekaterina V Vinogradova | Summary: Despite significant interest in therapeutic targeting of splicing, few chemical probes […]
Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]
Kavli Affiliate: Erich Jarvis | Authors: Daniel Cadena, Laura Pabon, Carlos DoNascimiento, Linelle Abueg, Tatiana Tiley, Brian O-Toole, Dominic Absolon, Ying Sims, Giulio Formenti, Olivier Fedrigo, Erich Jarvis and Mauricio Torres | Summary: Animals living in caves are of broad relevance to evolutionary biologists interested in understanding the mechanisms underpinning convergent evolution. In the Eastern […]
Kavli Affiliate: Shai Shaham | Authors: Colin W Hoy, Coralie de Hemptinne, Sarah S Wang, Catherine J Harmer, Matthew A J Apps, Masud Husain, Philip A Starr and Simon Little | Summary: Neurons have elaborate structures that determine their connectivity and functions. Changes in neuronal structure accompany learning and memory formation and are hallmarks of […]
Kavli Affiliate: Charles M. Rice | Authors: Soumyadev Sarkar, Anna Kazarina, Paige M. Hansen, Kaitlyn Ward, Christopher Hargreaves, Nicholas Reese, Qinghong Ran, Willow Kessler, Ligia F.T. de Souza, Terry D. Loecke, Marcos V.M. Sarto, Charles W. Rice, Lydia H. Zeglin, Benjamin A. Sikes and Sonny T.M. Lee | Summary: Global change has accelerated the nitrogen […]
Kavli Affiliate: Charles M. Rice | Authors: Lila D. Patterson, Benjamin D. Dubansky, Brooke H. Dubansky, Shannon Stone, Mukesh Kumar and Charles D Rice | Summary: The Coronavirus disease 2019 (COVID19) pandemic caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is an ongoing threat to global public health. To this end, intense efforts are underway to […]
Kavli Affiliate: Li Zhao | Authors: Qing Guo, Zhao-Feng Li, Dong-Yan Hu, Pei-Jun Li, Kai-Nian Wu, Hui-Hui Fan, Jie Deng, Hong-Mei Wu, Xiong Zhang and Jian-Hong Zhu | Summary: Attention deficit and hyperactivity disorder (ADHD) is a prevalent developmental disorder. SELENOT is an endoplasmic reticulum-resident selenocysteine-containing protein. We aimed to investigate the role of SELENOT […]
Kavli Affiliate: Vanessa Ruta | Authors: Tom Hindmarsh Sten, Rufei Li, Florian Hollunder, Shadé Eleazer and Vanessa Ruta | Summary: Males of many species have evolved behavioral traits to both attract females and repel rivals. Here, we explore mate selection in Drosophila from both the male and female perspective to shed light on how these […]
Kavli Affiliate: Eric D. Siggia | Authors: Archishman Raju and Eric Siggia | Summary: The lineage decision that generates the epiblast and primitive endoderm from the inner cell mass (ICM) is a paradigm for cell fate specification. Recent mathematics has formalized Waddington’s landscape metaphor and proven that lineage decisions in detailed gene network models must […]