Kavli Affiliate: Roderick MacKinnon | Authors: George Vaisey and Roderick MacKinnon | Summary: Piezo1 ion channels are widely expressed cellular mechanosensors. They adopt an intrinsically curved shape when closed and are thought to open when mechanical forces applied to the membrane favor a more flattened conformation. By reconstituting Piezo1 channels into lipid vesicles, a flattened […]
Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Luke Olsen, Javier Botella, Douglas Barrows, Ethan Romero, Kaitlyn Baird, Mutsumi Katayama, Ece Kilic, Christopher Peralta, Henry Sanford, Laurie Farrell, Christopher L Axelrod, Kaja Plucinska, Jeanne Walker, Lu Yan, Katie Fredrickson, Olivier Pourquie, Jeremy M. Robbins, Ekaterina V Vinogradova, John P. Kirwan, Juleen R. Zierath, Anna Krook, Robert […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Li Zhao | Authors: Pu-Yu Li, Fu-Li Zhao, Yi-Juan Song, Bing-Yao Lei, Hao-Jin Niu, Ying-Fang Wang and Hong-Wei Jiang | Summary: Maternal diabetes leads to neural tube defects (NTDs) in offspring. DNA methylation could be associated with NTDs induced by […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Shai Shaham | Authors: Simin Liu, Kenneth Bradley, Jinghong J. Tang, Yoon A. Kim, Ana Milosevic and Shai Shaham | Summary: Astrocytic glia regulate brain assembly, synapse formation/activity, neuronal energetics, and brain metabolism. Gene programs driving astrocyte specification are only […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Shai Shaham | Authors: Olya Yarychkivska, Lena M Kutscher, Dana Mamriev, Betty Ortiz Bido, Yun Lu, Wolfgang Keil, Sarit Larisch and Shai Shaham | Summary: Nuclear degradation accompanies cell death. To study this process, we followed nuclear dismantling of the […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Daniel Kronauer | Authors: Dominic D. Frank, Lindsey E. Lopes, Rishika Mohanta, Isabelle Seckler, Ivan Lacroix and Daniel J.C. Kronauers | Summary: Ants exhibit remarkable collective and social behaviors, such as alloparental care1, chemical communication2, homing3, and cooperative group hygiene4. […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Nivesh Jain, Jack A Medico, Marco Sollitto, Dmitry Antipov, Jennifer Balacco, Suziane Barcellos, Matthew T Biegler, Ines Borges, J King Chang, Ying Chen, Haoyu Cheng, Helena B Conceicao, Matthew Davenport, Lorraine C De Oliveira, […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Vanessa Ruta | Authors: Philipp Brand, Katherine Keller, Rory T. Coleman, Noelle B. Eghbali, Sarah Zylka, Lucia L. Prieto-Godino and Vanessa Ruta | Summary: Mating decisions are often attributed to the sensory signaling between prospective sexual partners. Yet these interactions […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Stephen Strittmatter | Authors: Ramakrishnan Kannan, Xingxing Wang, LaShae Nicholson, Nancy Z. Lin, Elisa M. Howard, Atrayee Basu, Ines Ingabire, Yuichi Sekine and Stephen M. Strittmatter | Summary: Adult CNS trauma frequently causes neuronal disconnection and persistent deficits due to […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Alexander J Stuart, Kaori Takai, Railia R. Gabbasova, Henry Sanford, Ekaterina V. Vinogradova and Titia de Lange | Summary: Replicative senescence, a powerful tumor suppressor pathway, occurs when a few critically-short telomeres activate the DNA […]