Whole-brain neural substrates of behavioral variability in the larval zebrafish

Kavli Affiliate: Alipasha Vaziri | Authors: Jason Manley and Alipasha Vaziri | Summary: Animals engaged in naturalistic behavior can exhibit a large degree of behavioral variability even under sensory invariant conditions. Such behavioral variability can include not only variations of the same behavior, but also variability across qualitatively different behaviors driven by divergent cognitive states, […]


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Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

Kavli Affiliate: Leslie B. Vosshall and Michael Miller | Authors: Emely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall and Laura B. Duvall | Summary: Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required […]


Continue.. Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

Overexpression of PpGL2 from Prunus persica enhanced soybean drought tolerance

Kavli Affiliate: Li Zhao | Authors: Wei Li, Dahong Li, Li Zhao and Hongyan Li | Summary: The HD-ZIP transcription factor family plays crucial roles in plant growth and abiotic stress responses. While its diverse functions and regulatory mechanisms are well-documented, its role in conferring abiotic stress tolerance in peaches remains largely unexplored. Here, we […]


Continue.. Overexpression of PpGL2 from Prunus persica enhanced soybean drought tolerance

The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Nicolas Svetec, Henrik Molina and Li Zhao | Summary: Post-mating responses play a vital role in successful reproduction across diverse species. In fruit flies, sex peptide (SP) binds to sex peptide receptor (SPR), triggering a series of post-mating responses. However, the origin of SPR predates the emergence […]


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A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Kavli Affiliate: Alipasha Vaziri | Authors: Yaunlong Zhang, Lekang Yuan, Jiamin Wu, Tobias Noebauer, Rujin Zhang, Guihua Xiao, Mingrui Wang, Hao Xie, Qionghai Dai and Alipasha Vaziri | Summary: Understanding how neuronal dynamics gives rise to ethologically relevant behavior requires recording of neuronal population activity via technologies that are compatible with unconstrained animal behavior. However, […]


Continue.. A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Multiple objects evoke fluctuating responses in several regions of the visual pathway

Kavli Affiliate: Winrich Freiwald | Authors: Meredith N Schmehl, Valeria C Caruso, Yunran Chen, Na Young Jun, Shawn M Willett, Jeff T Mohl, Douglas A Ruff, Marlene R Cohen, Akinori Ebihara, Winrich Freiwald, Surya T Tokdar and Jennifer M Groh | Summary: How neural representations preserve information about multiple stimuli is mysterious. Because tuning of […]


Continue.. Multiple objects evoke fluctuating responses in several regions of the visual pathway

A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry

Kavli Affiliate: Jean-Laurent Casanova, Charles M. Rice | Authors: Jeremie Le Pen, Gabrielle Paniccia, Michael Bauer, H.-Heinrich Hoffmann, Volker Kinast, Marcela Moncada-Velez, Ana Pinharanda, Inna Ricardo-Lax, Ansgar F Stenzel, Edwin A Rosado-Olivieri, Alison W Ashbrook, Kenneth H Dinnon, William Doyle, Catherine Freije, Seon-Hui Hong, Danyel Lee, Tyler Lewy, Joseph M Luna, Avery Peace, Carltin Schmidt, […]


Continue.. A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Kavli Affiliate: Mary E. Hatten | Authors: Michalina Hanzel, Kayla Fernando, Susan E Maloney, Shioaching Gong, Kärt Mätlik, Jiajia Zhao, H Amalia Pasolli, Søren Heissel, Joseph D Dougherty, Court Hull and Mary E Hatten | Summary: Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and […]


Continue.. Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Ryan J Farrell, Kirsten G Bredvik, Michael Blake Hoppa, S Thomas Hennegan, Timothy A Brown and Timothy A Ryan | Summary: The endoplasmic reticulum (ER) is an important regulator of Ca2+ in cells and dysregulation of ER calcium homeostasis can lead to numerous pathologies. Understanding how […]


Continue.. A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Using artificial intelligence to document the hidden RNA virosphere

Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]


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