Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.

Posted by dbos Rockefeller

Kavli Affiliate: Jeffrey M. Friedman and Ekaterina V. Vinogradova | Authors: Kaja Plucinska, Charlotte R Wayne, Henry Sanford, Boby Mathew, Nathalie Ropek, Stephanie M Adaniya, Corey Model, Nicolas Gomez-Banoy, Ksenia Morozova, Xiongwen Cao, Jeffrey M. Friedman, Ken H. Loh, Paul Cohen and Ekaterina V Vinogradova | Summary: Intercellular communication is critical for maintaining organismal metabolic […]


Continue.. Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.

A commensally regulated immune rheostat fine-tunes skin barrier fitness

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Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Elaine Fuchs | Authors: Anita Gola, Rohith Srinivas, Elias G. Rodig, Marina Schernthanner, Merve Deniz Abdusselamoglu, Matthew T. Tierney, Natalie J. Alexander, Kevin A.U. Gonzales, Sairaj M. Sajjath, Luis F. Soto-Ugaldi, Alain R. Bonny and Elaine Fuchs | Summary: At […]


Continue.. A commensally regulated immune rheostat fine-tunes skin barrier fitness

C. elegans E3 ubiquitin ligase EBAX-1 promotes non-apoptotic linker cell-type death through target-directed miRNA degradation

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Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Shai Shaham | Authors: Lauren B Horowitz, Olya Yarychkivska, Yun Lu and Shai Shaham | Summary: Programmed cell death is essential for animal development and homeostasis, and its disruption accompanies many human disorders. Linker cell-type death (LCD) is a morphologically […]


Continue.. C. elegans E3 ubiquitin ligase EBAX-1 promotes non-apoptotic linker cell-type death through target-directed miRNA degradation

Biological signatures of history: Examination of composite biomes and Y chromosome analysis from da Vinci-associated cultural artifacts

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Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Thomas P. Sakmar | Authors: Harinder Singh, Seesandra V Rajagopala, Rebecca Hart, Pille Hallast, Mark Loftus, Rosana Wiscovitch-Russo, Cody R. K. Conrad, David S Thaler, Guadalupe Piñar, Karina C Åberg, Rosella Lorenzi, Jose A Lorente, Jesse H Ausubel, Thomas P […]


Continue.. Biological signatures of history: Examination of composite biomes and Y chromosome analysis from da Vinci-associated cultural artifacts

Radial-glia-to-astrocyte trans-differentiation and astrocyte transcriptional convergence are coordinated by CEH-43/DLX in C. elegans

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Kavli Affiliate: Shai Shaham | Authors: Simin Liu, Kenneth Bradley, Jinghong J. Tang, Yoon A. Kim, Ana Milosevic and Shai Shaham | Summary: Mammalian radial glia can remodel to become astrocytes, which acquire common transcriptional states despite spatially and lineally distinct origins. To uncover molecular programs driving convergent radial-glia-to-astrocyte transformation, we investigated development of C. […]


Continue.. Radial-glia-to-astrocyte trans-differentiation and astrocyte transcriptional convergence are coordinated by CEH-43/DLX in C. elegans

Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD

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Kavli Affiliate: A. James Hudspeth | Authors: Teng Han, Zhen Sun, Matthew Lange, Y Zoe Cho, Patrick Mcgillivray, Maren Buttner, Nathaniel R Kastan, Subhiksha Nandakumar, Huiyong Zhao, Sanyukta Oak, Linda Fong, Wenfei Kang, Ning Fan, Jimmy Zhao, Nazifa Salsabeel, Harmanpreet Kaur, Ninghui Mao, Qing Chang, Eric Rosiek, Eric Chan, Murray Tipping, Nikolaus Schultz, Pierre-Jacques Hamard, […]


Continue.. Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD

Neural representation of action symbols in primate frontal cortex

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Kavli Affiliate: Winrich Freiwald | Authors: Lucas Y Tian, Kedar Garzón Gupta, Daniel J. Hanuska, Adam G Rouse, Mark AG Eldridge, Marc H Schieber, Xiao-Jing Wang, Joshua B Tenenbaum and Winrich A Freiwald | Summary: A hallmark of intelligence is proficiency in solving new problems, including those that differ dramatically from problems seen before. Problem-solving, […]


Continue.. Neural representation of action symbols in primate frontal cortex

High-Fidelity Tuning of Olfactory Mixture Distances in the Perceptual Space of Smell Through a Community Effort

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Kavli Affiliate: Leslie B. Vosshall | Authors: Vahid Satarifard, Laura Sisson, Yikun Han, Pedro Ilidio, Matej Hladis, Maxence Lalis, Xuebo Song, Wenjie Yin, Aharon Ravia, CiCi Xingyu Zheng, Gaia Andreoletti, Jake Albrecht, Robert Pellegrino, Zehua Wang, Stephen Yang, Robbe D’hondt, Achilleas Ghinis, Jasper de Boer, Felipe Kenji Nakano, Alireza Gharahighehi, DREAM Olfactory Mixtures Prediction Consortium, […]


Continue.. High-Fidelity Tuning of Olfactory Mixture Distances in the Perceptual Space of Smell Through a Community Effort

A cross-species spatial transcriptomic atlas of the human and non-human primate basal ganglia

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Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Winrich Freiwald | Authors: Nelson J. Johansen, Yuanyuan Fu, Matthew Schmitz, Alma Dubuc, Niklas Kempynck, Morgan Wirthlin, Aaron D. Garcia, Madeleine Hewitt, Meghan A. Turner, Stephanie C. Seeman, Brian Long, Xiao-Ping Liu, Shu Dan, Michael DeBerardine, Inkar Kapen, Anna Marie […]


Continue.. A cross-species spatial transcriptomic atlas of the human and non-human primate basal ganglia

Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s disease

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Kavli Affiliate: Nathaniel Heintz | Authors: Matthew Baffuto, Kert Mätlik, Isaac Ilyashov, Maria Esterlita Siantoputri, Hasnahana Chetia, Yurie Harada, Erika Sipos, Paul Darnell, Laura Kus, Thomas Carroll, Douglas Barrows, Christina Pressl, Nicholas Didkovsky and Nathaniel Heintz | Summary: Huntington’s disease (HD) is characterized by neuronal dysfunction and degeneration that varies markedly by brain region and […]


Continue.. Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s disease