Kavli Affiliate: Li Zhao | Authors: Yuntao Yang, Li Zhao, Seyedmehdi Orouji, Ying Zhu, Rebecca L Johnson, David S Maxwell, Ioan Mica, Kaitlyn P Russell and Bissan Al-lazikani | Summary: Confirming target engagement in tumor experimental models remains a major challenge in oncology drug development. Pharmacodynamic biomarkers can help address this, but few systematic resources […]

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Li Zhao | Authors: Xingxin Pan, Aditya Shrawat, Sidharth Raghavan, Chuanpeng Dong, Yuntao Yang, Zhao Li, W. Jim Zheng, S. Gail Eckhardt, Erxi Wu, Juan I Fuxman Bass, Daniel F Jarosz, Sidi Chen, Daniel J McGrail, Gloria M Sheynkman, Jason […]

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Erich Jarvis | Authors: Young Ho Lee, Chul Lee, Erich Jarvis and Heebal Kim | Summary: Genomic promoters are crucial gene regulatory elements1,2. Yet, comparative analyses of promoter architecture have been constrained by the limited resolution of GC-rich regions in […]

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Erich Jarvis | Authors: Ivana Pacar, Matteo Tommaso Ungaro, Ying Chen, Hamza Dallali, Jack A. Medico, Prajna Hebbar, Mark Diekhaus, Elena Di Tommaso, Margarita Geleta, Patricia P. Chan, Todd M. Lowe, Jennifer Balacco, Nivesh Jain, Francine Ackerman, Michela Mochi, Alexander […]

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Erich Jarvis | Authors: Linnea Smeds, Jacob P Sieg, Simona Secomandi, Chul Lee, Marco Sollitto, Jack A Medico, Francesca Chiaromonte, Erich D Jarvis, Giulio Formenti and Kateryna D Makova | Summary: Non-canonical (non-B) DNA motifs are sequences that can fold […]

Kavli Affiliate: Jean-Laurent Casanova | Authors: Diana Olguin Calderon, Laura E. Kilpatrick, Clement Conil, Quentin Philippot, Masato Ogishi, Joseph Vellutini, Ji Eun Han, Narelle Keating, Hailun Li, Geetha Rao, Jonathan Bohlen, Charles S. Lay, Simon Platt, Gaspard Kerner, Elsa Feredj, Jessica Peel, Mana Momenilandi, Yoann Seeleuthner, Candice Laine, camille soudee, Claire Leloup, Cecile Debuisson, Fanny […]

Kavli Affiliate: Nathaniel Heintz | Authors: Alan Umfress, Patrick Wertimer, Christina Pressl, Matthew Baffuto, Kert Mätlik, Franchesca Fernandez, Maria Esterlita Siantoputri, Ines Ibañez-Tallon and Nathaniel Heintz | Summary: G Protein coupled receptors (GPCRs) are the largest class of clinically validated drug targets with nearly 35% of all approved therapeutic agents acting on these receptors. To […]

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Shanshan Liu, Mark Gad, Caifan Li, Kevin Cho, Yuyang Liu, Khando Wangdu, Viktor Belay, Alon Millet, Hiroyuki Kojima, Henry Sanford, Michele Wolk, Linas Urnavicius, Maria Fedorova, Gary J. Patti, Ekaterina V. Vinogradova, Richard K. Hite and Kivanc Birsoy | Summary: The endoplasmic reticulum (ER) requires an oxidative environment […]

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Hiroyuki Kojima, Charlotte R Wayne, Luis F. Somarribas Patterson, Henry Sanford, Tzu-Jou Chen, Ya-Hui Lin, Joshua D. Schoenfeld, Lisa H. F. McGary, Yan-Ting Chen, Korbinian N. Kropp, Beatrice Zhang, Jahan Rahman, Tiffany L. Zhang, Nathalie Ropek, Cameron Roberts, Yuxi Ai, Kartikeya Menon, A. Ari Hakimi, Jiankun Lyu, Christopher […]

Kavli Affiliate: Nathaniel Heintz | Authors: Chris Kay, Jessica Dawson, Kert Mätlik, Hailey Findlay Black, Emily Harvey, Stephanie Bortnick, Kyla Javier, Christina Buchanan, Tanu Soomarooah, Inês Caldeira Brás, Glen Sequiera, Mahmoud Pouladi, Larissa Arning, Hoa HP Nguyen, Richard Roxburgh, Maurice Curtis, Richard LM Faull, Nathaniel Heintz and Michael R Hayden | Summary: Synonymous loss of […]