Kavli Affiliate: Shai Shaham | Authors: Nikolaos Stefanakis, Jessica Jiang, Yupu Liang and Shai Shaham | Summary: While most CNS glia arise from neuroectodermal progenitors, some, like microglia, are mesodermally derived. To understand mesodermal glia development and function, we investigated C. elegans GLR glia, which ensheath the brain neuropil and separate it from the circulatory-system […]

Kavli Affiliate: A. James Hudspeth | Authors: Camila M. Villasante, Xinyue Deng, Joel E. Cohen and A.J. Hudspeth | Summary: Mechanical force controls the opening and closing of mechanosensitive ion channels atop the hair bundles of the inner ear. The filamentous tip link connecting transduction channels to the tallest neighboring stereocilium modulates the force transmitted […]

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Matthew R Paul, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in Huntington’s disease (HD) cortex, the nature of somatic […]

Kavli Affiliate: Priya Rajasethupathy | Authors: Josue M Regalado, Ariadna Corredera Asensio, Theresa Haunold, Andrew C Toader, Yan Ran Li, Lauren A Neal and Priya Rajasethupathy | Summary: Learning requires the ability to link actions to outcomes. How motivation facilitates learning is not well understood. We designed a behavioral task in which mice self-initiate trials […]

Kavli Affiliate: A. James Hudspeth | Authors: Ryohei Oya, Kwang Min Woo, Brian Fabella, Rodrigo Gogui Alonso and Albert James Hudspeth | Summary: In the receptor organs of the inner ear and lateral line, sensory hair cells detect mechanical stimuli such as sounds, accelerations, and water movements. In each instance a stimulus deflects the hair […]

Kavli Affiliate: Winrich Freiwald | Authors: Ben Deen, Gasi Husain and Winrich A Freiwald | Summary: How does the brain process the faces of familiar people? Neuropsychological studies have argued for an area of the temporal pole (TP) linking faces with person identities, but magnetic susceptibility artifacts in this region have hampered its study with […]

Kavli Affiliate: Leslie B. Vosshall | Authors: Takeshi Morita, Nia G Lyn, Ricarda K von Heynitz, Olivia V Goldman, Trevor R Sorrells, Matthew DeGennaro, Benjamin J Matthews, Leah Houri-Zeevi and Leslie B Vosshall | Summary: Sensory compensation is a process that allows individuals with a loss of one sense, for instance hearing or vision, to […]

Kavli Affiliate: Daniel Mucida | Authors: Gregory P. Donaldson, Gabriella L. Reis, Marwa Saad, Izabela Mamede, Guo Chen, Nicole L. DelGaudio, Dayu Zhang, Begum Aydin, Caroline E. Harrer, Tiago B.R. Castro, Sergei Grivennikov, Bernardo S. Reis, Beth M. Stadtmueller, Gabriel D. Victora and Daniel Mucida | Summary: Immunoglobulin A (IgA) is the most abundant antibody […]

Kavli Affiliate: Mary E. Hatten, C. David Allis | Authors: Lijuan Feng, Douglas Barrows, Liangwen Zhong, Kart Matlik, Elizabeth G. Porter, Annaelle M. Djomo, Iris Yau, Alexey A. Soshnev, Thomas S. Carroll, Duancheng Wen, Mary E. Hatten, Benjamin A. Garcia and C. David Allis | Summary: Chromatin is a crucial regulator of gene expression and […]