The Vertebrate Genomes Project Phase I: A global reference genome resource

Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Dominic E. Absolon, Linelle Ann L. Abueg, Francine Ackerman, Farooq Omar Al-Ajli, Alexandre Aleixo, Agostinho Antunes, Dahiana Arcila, Jean-Nicolas Audet, Jennifer R. Balacco, Alan James Stephen Beavan, Katherine Belov, Ricardo Betancur-R., Shelby L Bidwell, Matthew T Biegler, Iliana Bista, Mark Blaxter, Kevin Boyer, Ingo Braasch, Ian R […]


Continue.. The Vertebrate Genomes Project Phase I: A global reference genome resource

Zinc coordination by the wheat rust effector AvrSr33 provides a structural scaffold required for immune recognition

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Jian Chen, Emily M Cross, Megan A Outram, Daniel S Yu, Jana Sperschneider, Melania Figueroa, Peter N Dodds and Simon J Williams | Summary: Interactions between plants and pathogens drive long-term co-evolution through cycles of effector diversification and immune recognition. Effectors play central roles in this molecular […]


Continue.. Zinc coordination by the wheat rust effector AvrSr33 provides a structural scaffold required for immune recognition

Rust fungi secretomes contain structurally diverse effector families including cysteine-rich metal-binding proteins

Kavli Affiliate: Li Zhao | Authors: Megan Outram, Zhao Li, Michael Kuiper, Simon J Williams, Melania Figueroa, Peter Dodds and Jana Sperschneider | Summary: Rust fungi are significant threats to global food security, causing substantial damage to crops through their ability to adapt and evolve new strains that overcome resistance. These obligate biotrophs infect host […]


Continue.. Rust fungi secretomes contain structurally diverse effector families including cysteine-rich metal-binding proteins

Dengue virus infection in Aedes aegypti mosquito brains elicits minimal transcriptional response

Kavli Affiliate: Leslie B. Vosshall | Authors: Umberto Palatini, Stéphanie Dabo, Adriana Rosas-Villegas, Yael N. Tsitohay, Alexandra E. DeFoe, Nadav Shai, Louis Lambrechts and Leslie B. Vosshall | Summary: Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. […]


Continue.. Dengue virus infection in Aedes aegypti mosquito brains elicits minimal transcriptional response

Eosinophil-epithelial interactions mediate protective intestinal remodeling during food allergy

Kavli Affiliate: Daniel Mucida | Authors: Patrick W Darcy, Vitoria M Olyntho, Albana Kodra, Zachary Kerner, Maria C.C. Canesso, Sandra Nakandakari-Higa, Gabriel Victora and Daniel Mucida | Summary: Food allergies are associated with progressive gastrointestinal symptoms driven by exacerbated mucosal type-2 immunity. Here, we investigated whether cellular interactions between the gut epithelium and innate immune […]


Continue.. Eosinophil-epithelial interactions mediate protective intestinal remodeling during food allergy

A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralization

Kavli Affiliate: Charles M. Rice | Authors: Trinity Zang, Viren A Baharani, Miranda Aldis, Marie Canis, Rachel Patejak, Edmund Osei Kuffour, Hans Heinrich Hoffman, Harm van Bakel, Emilia M Sordillo, Viviana Simon, Margaret R MacDonald, Charles M Rice, Michel C Nussenzweig, Theodora Haziionannou and Paul D Bieniasz | Summary: A central problem in achieving vaccine-based […]


Continue.. A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralization

Large-scale volumetric two-photon calcium imaging enables cellular-resolution mesoscopic mapping of marmoset cortical areas

Kavli Affiliate: Winrich Freiwald and Alipasha Vaziri | Authors: Santiago Otero-Coronel, David Grant Colburn Hildebrand, Tobias Noebauer, Jeffrey Demas, Brandon Chen, Siegfried Weisenburger, Frank Tejera, Sverre Grodem, Kristian Kinden Lensjo, Guro Helen Vatne, Marianne Fyhn, Winrich A Freiwald and Alipasha Vaziri | Summary: Primate neocortex is organized into functionally defined domains. Understanding how the functional […]


Continue.. Large-scale volumetric two-photon calcium imaging enables cellular-resolution mesoscopic mapping of marmoset cortical areas

A flow cytometry-based assay to quantify the binding of transmembrane ligands to their cognate receptors using fluorescent virus-like particles

Kavli Affiliate: Jean-Laurent Casanova | Authors: Colin Kim, Maira Gaballa, Danyel Lee, Emmanuelle Jouanguy, Shen-Ying Zhang, Jean-Laurent Casanova and Ahmad Yatim | Summary: The binding of transmembrane (TM) ligands to their cognate TM receptors on neighboring cells governs intercellular adhesion and direct cell–cell communication. However, these interactions are difficult to study in vitro because they […]


Continue.. A flow cytometry-based assay to quantify the binding of transmembrane ligands to their cognate receptors using fluorescent virus-like particles

Long-term maintenance of H3K27me3 in postmitotic neurons is dispensable for gene expression regulation

Kavli Affiliate: C. David Allis and Mary E. Hatten | Authors: Irma Laas, Matthew R Paul, Natarajan Bhanu, Lijuan Feng, Eve-Ellen Govek, Benjamin A Garcia, Thomas S Carroll, C David Allis, Mary E. Hatten and Kärt Mätlik | Summary: Neuronal maturation is associated with extensive changes in gene expression and chromatin organization. However, the molecular […]


Continue.. Long-term maintenance of H3K27me3 in postmitotic neurons is dispensable for gene expression regulation

Notch-driven fate asymmetry dictates hair cell behavior via a fate-specific kinase

Kavli Affiliate: A. James Hudspeth | Authors: Emily Atlas, Caleb C. Reagor, Brian Frost, Sapna Krishnakumar, A. J. Hudspeth and Adrian Jacobo | Summary: Cell-cell signaling and cell-fate decisions are essential for organ assembly, but how these molecular events translate into the physical properties and cell behaviors that drive development remains poorly understood. In the […]


Continue.. Notch-driven fate asymmetry dictates hair cell behavior via a fate-specific kinase