Kavli Affiliate: Charles M. Rice | Authors: Antonis Athanasiadis, Georgios Dangas, Ansgar F. Stenzel, Paul Park, Anthi Maslarinou, Evgenia Moschogianni, Allan Henrique Depieri Cataneo, Catherine A Freije, Yichen Zhou, Kenneth C Levenson, Corrine Quirk, Chenhui Zou, William Matthew Schneider, Adriano Aguzzi, Charles M Rice, Ype P De Jong and Eleftherios Michailidis | Summary: More than […]

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Background Highly variable gene (HVG) selection begins almost every single-cell RNA-seq analysis. While ranking formulas have been compared extensively, the integer gene budget at which any ranking must be truncated is typically left to the user and habitually fixed near 2,000. […]

Kavli Affiliate: Erich Jarvis | Authors: Josephine R Paris, Linelle Abueg, Sarah Pelan, Ying Sims, Tatiana Tilley, Jacquelyn Mountcastle, Jennifer Balacco, Brian O’Toole, Olivier Fedrigo, Giulio Formenti, Erich D Jarvis, Daniele Canestrelli and Daniele Salvi | Summary: The European leaf-toed gecko (Euleptes europaea) is a small, nocturnal gecko endemic to the western Mediterranean. As a […]

Kavli Affiliate: Jean-Laurent Casanova | Authors: Diana Olguín Calderón, Laura E. Kilpatrick, Clément Conil, Quentin Philippot, Masato Ogishi, Joseph Vellutini, Ji Eun Han, Narelle Keating, Hailun Li, Geetha Rao, Jonathan Bohlen, Charles S. Lay, Simon Platt, Gaspard Kerner, Elsa Feredj, Jessica N. Peel, Mana Momenilandi, Yoann Seeleuthner, Candice Lainé, Camille Soudée, Claire Leloup, Cecile Debuisson, […]

  Kavli Affiliate: Timothy A. Ryan | Authors: Alexandros C. Kokotos, Santiago R. Unda, Paula R Reyes-Perez, Mariam Isayan, Maria Teresa Perinan, Michael G Kaplitt and Timothy A Ryan | Summary: Several Parkinson’s Disease (PD) linked mutations are known to drive deficits in a pathway that relies on an adequate supply of guanosine nucleotide triphosphate […]

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Single-cell differential expression (DE) reports changes in mature mRNA abundance, but the same fold-change can reflect faster synthesis or slower decay. Metabolic labeling resolves this ambiguity but is costly and cannot be applied retrospectively to the vast majority of published […]

  Kavli Affiliate: Erich Jarvis | Authors: Julian K. Lucas, Prajna Hebbar, Wen-Wei Liao, Juan F. Macias-Velasco, Adam M. Novak, Mobin Asri, Jennifer R. Balacco, Andrew P. Blair, Davide Bolognini, Jana Ebler, Joshua M.V. Gardner, Margarita Geleta, Cristian Groza, Andrea Guarracino, Peter Heringer, Glenn Hickey, Sergey Koren, Shuangjia Lu, Maximillian G. Marin, Christopher Markovic, Mira […]

  Kavli Affiliate: Winrich Freiwald | Authors: Song-Lin Ding, Ashwin Bhandiwad, Burke Rosen, Stephanie C. Seeman, Brian Long, Nelson J. Johansen, Ugur Bayindir, Benjamin Facer, Yuanyuan Fu, Yoel Halimi, Yujie Hou, Dingzi Hu, Mike Huang, Takuro Ikeda, Brian Kalmbach, Lauren Kruse, Phil Lesnar, Xiao-Ping Liu, Zhaoke Luo, Patrick Ray, Joshua J Royall, Matthew T Schmitz, […]

Kavli Affiliate: Roderick MacKinnon | Authors: Maria Falzone, Priyam Banerjee and Roderick MacKinnon | Summary: PLCβ enzymes cleave PIP2 from the plasma membrane, producing IP3 and DAG, which regulate intracellular Ca2+ levels and protein kinase C activity, respectively. They are regulated by GPCR signaling through the G proteins Gβγ and Gαq and have been shown […]

  Kavli Affiliate: Charles M. Rice | Authors: Catherine A Freije, Georgios Dangas, Antonis Athanasiadis, Evgenia Moschogianni, Madeleine K Sanders, Allan Henrique Depieri Cataneo, Chloe K Boehm, Maria Bousali, Dar-Yin Li, Sooyoung Lee, Guillaume Cornelis, Gary Lo, Leah B Soriaga, Amalio Telenti, Julia di Iulio, Ana L P Mosimann, Juliano Bordignon, Kirin Karver, Lukas Fu, […]