Kavli Affiliate: Michael W. Young | Authors: Waruna Thotamune, Sithurandi Ubeysinghe, Kendra Kumar Shrestha, Mahmoud Elhusse Mostafa, Michael C Young and Ajith Karunarathne | Summary: Beta-adrenergic receptors (βARs) are G protein-coupled receptors (GPCRs) that mediate catecholamine-induced stress responses, such as heart rate increase and bronchodilation. In addition to signals from the cell surface, βARs also […]

Kavli Affiliate: Daniel Kronauer | Authors: Taylor Hart, Lindsey E. Lopes, Dominic D. Frank and Daniel J.C. Kronauer | Summary: While the neural basis of age-related decline has been extensively studied (1–3), less is known about changes in neural function during the pre-senescent stages of adulthood. Adult neural plasticity is likely a key factor in […]

Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Taylor Hart and Daniel J.C. Kronauer | Summary: According to Mendel’s second law, chromosomes segregate randomly in meiosis. Non-random segregation is primarily known for cases of selfish meiotic drive in females, in which particular alleles bias their own transmission into the oocyte1,2. Here, we report a […]

Kavli Affiliate: Erich Jarvis | Authors: Jun Ishigohoka, Karen Bascón-Cardozo, Andrea Bours, Janina Fuß, Arang Rhie, Jacquelyn Mountcastle, Bettina Haase, William Chow, Joanna Collins, Kerstin Howe, Marcela Uliano-Silva, Olivier Fedrigo, Erich D. Jarvis, Javier Pérez-Tris, Juan Carlos Illera and Miriam Liedvogel | Summary: Genetic variation of the entire genome represents population structure, yet individual loci […]

Kavli Affiliate: Erich Jarvis | Authors: Elena N Waidmann, Victor HY Yang, William C Doyle and Erich D Jarvis | Summary: Vocal communication is a major component of animal social behavior. Vocalizations can be learned or innate, and can convey a variety of signals, including territorial limits, the presence of predators, or courtship intent. Mouse […]

Kavli Affiliate: Erich Jarvis | Authors: César D M Vargas, Rajvi K Agravat, Elena N Waidmann, Christodoulos Bochalis, Hector Bermudez, Theodoros Giannakopoulos and Erich D Jarvis | Summary: Vocalization is a complex behavior ranging from fully innate to advanced vocal learning. Vocal learning species possess a vocal primary motor cortex (M1) region that makes direct […]

Kavli Affiliate: Stanislas Leibler | Authors: Pablo Sartori and Stanislas Leibler | Summary: One of the tenets of molecular biology is that dynamical transitions between three dimensional structures largely determine the function of individual proteins, as well as multi-protein assemblies. Therefore, it seems only natural that evolutionary analysis of proteins, presently based mainly on their […]

Kavli Affiliate: Li Zhao | Authors: Yuntao Yang, Yuhan Xie, Zhao Li, Chiamaka Diala, Meer Ali, Rongbin Li, Yi Xu, Albon Wu, Pora Kim, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao and W. Jim Zheng | Summary: Alternative splicing is an important cellular process in eukaryotes, altering pre-mRNA to yield multiple protein isoforms from a single […]

Kavli Affiliate: Roderick MacKinnon | Authors: Gonzalo Pérez-Mitta, Yeliz Sezgin, Weiwei Wang and Roderick MacKinnon | Summary: Abstract Integral membrane proteins (IMPs) constitute a large fraction of organismal proteomes, playing fundamental roles in physiology and disease. Despite their importance, the mechanisms underlying dynamic features of IMPs, such as anomalous diffusion, protein-protein interactions, and protein clustering, […]

Kavli Affiliate: Sidney Strickland | Authors: Pradeep K Singh, Elisa Nicoloso Simoes-Pires, Zu-Lin Chen, Daniel Torrente, Marissa Calvano, Anurag Sharma, Sidney Strickland and Erin H Norris | Summary: Proteinaceous brain inclusions, neuroinflammation, and vascular dysfunction are common pathologies in Alzheimer’s disease (AD). Vascular deficits include a compromised blood-brain barrier, which can lead to extravasation of […]