Kavli Affiliate: Daniel Mucida | Authors: Roham Parsa, Helder Carvalho de Assis, Tiago B.R. de Castro, Gabriella Lima dos Reis, Arpita Sushil, Harald Hartweger, Angelina Bilate and Daniel Mucida | Summary: Pathogen-specific CD4⁺ T cells undergo dynamic expansion and contraction during infection, ultimately generating memory clones that shape the subsequent immune responses. However, the influence […]

Kavli Affiliate: Li Zhao | Authors: Yang Jiang, Xiaoyang Liu, Li Zhao and Zhong-Yuan Lu | Summary: Intrinsically disordered regions (IDRs) are pervasive in eukaryotic proteomes and play central roles in regulatory complexity and evolutionary innovation. While their conformational ensembles have been extensively characterized in isolation, most long IDRs function within multidomain proteins, where domain […]

Kavli Affiliate: Erich Jarvis | Authors: Tanya M Lama, Blair P Bentley, Warren E Johnson, Lisa M Komoroske, Stephen DeStefano, Jennifer Vashon, Kaela Beauclerc, Jason M Kamilar, Giulio Formenti, Andrea Batista, Andrew G Spencer, Olivier Federigo, Erich D Jarvis, Jeff S Bowman, Paul Wilson and John F Organ | Summary: Species must acclimate, shift their […]

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kivanc Birsoy, Shanshan Liu, Mark Gad, Caifan Li, Kevin Cho, Yuyang Liu, khando Wangdu, Victor Belay, Alon Millet, Hiroyuki Kojima, Henry Sanford, Michele Wolk, Linas Urnavicius, Maria Fedorova, Gary J. J. Patti, Ekaterina V Vinogradova and Richard K Hite | Summary: Grasslands, as one of the most important […]

Kavli Affiliate: Nathaniel Heintz | Authors: Bianca A Cotto, Lizi Zhang, Benjamin W Fait, Christopher Peralta, Ece Kilic, Henrik Molina, Nathaniel Heintz and Eric F Schmidt | Summary: Neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) exhibit striking cell-type selectivity, yet the basis for this vulnerability remains elusive. Here, we uncover that even closely related neurons […]

Kavli Affiliate: Daniel Mucida and Elaine Fuchs | Authors: Sara Martina Parigi, Sairaj Munavar Sajjath, Charlotte Jeanne Bell, Shaopeng Yuan, Vitoria Murakami Olyntho, Alain Robert Bonny, Sandra Nakandakari-Higa, Sergio Lira, Daniel Mucida, Gabriel D Victora and Elaine Fuchs | Summary: In adult tissues, epithelial stem cells exist within distinct residences, each endowing them with exclusive […]

Kavli Affiliate: Shai Shaham | Authors: Olya Yarychkivska, Lena M Kutscher, Betty Ortiz Bido, Juliana Kagan, Yoon A Kim, Dana Mamriev, Yun Lu, Elli Puscher, Wolfgang Keil, Sarit Larisch and Shai Shaham | Summary: dismantling of the C. elegans linker cell, which undergoes non-apoptotic morphologically-conserved cell death characterized by nuclear envelope crenellations and cell splitting. […]

Kavli Affiliate: Stefano Fusi | Authors: Ramon Nogueira, Saleh Esteki, Stefano Fusi and Roozbeh Kiani | Summary: Humans and other animals can solve new problems, even on the first attempt. This capacity to generate novel problem-solving behavior has been hypothesized to depend on brain mechanisms for recombining units of knowledge using systems of procedural rules, […]

Kavli Affiliate: Jeffrey M. Friedman and Ekaterina V. Vinogradova | Authors: Kaja Plucinska, Charlotte R Wayne, Henry Sanford, Boby Mathew, Nathalie Ropek, Stephanie M Adaniya, Corey Model, Nicolas Gomez-Banoy, Ksenia Morozova, Xiongwen Cao, Jeffrey M. Friedman, Ken H. Loh, Paul Cohen and Ekaterina V Vinogradova | Summary: Intercellular communication is critical for maintaining organismal metabolic […]

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Elaine Fuchs | Authors: Anita Gola, Rohith Srinivas, Elias G. Rodig, Marina Schernthanner, Merve Deniz Abdusselamoglu, Matthew T. Tierney, Natalie J. Alexander, Kevin A.U. Gonzales, Sairaj M. Sajjath, Luis F. Soto-Ugaldi, Alain R. Bonny and Elaine Fuchs | Summary: At […]