Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Lichirui Zhang, Richard Friesner and Ann E McDermott | Summary: NMR chemical shifts provide a sensitive probe of protein structure and dynamics. Prediction of shifts, and therefore interpretation of shifts, particularly for the frequently measured amidic 15N sites, remains a tall challenge. We demonstrate that protein 15N […]

Kavli Affiliate: Ann McDermott | Authors: Yizhuo Yang, Keith Fritzsching, Sasha He and Ann E McDermott | Summary: T-Cell Intracellular Antigen-1 (TIA1) is a 43 kDa multi-domain RNA-binding protein involved in stress granule formation during eukaryotic stress response, and has been implicated in neurodegenerative diseases including Welander distal myopathy and amyotrophic lateral sclerosis. TIA1 contains […]

Kavli Affiliate: Kenneth Miller | Authors: Agostina Palmigiano, Francesco Fumarola, Daniel P. Mossing, Nataliya Kraynyukova, Hillel Adesnik and Kenneth Miller | Summary: The visual cortex receives non-sensory inputs containing behavioral and brain state information. Here we propose a parallel between optogenetic and behavioral modulations of activity and characterize their impact on cell-type-specific V1 processing under […]

Kavli Affiliate: Steven Siegelbaum | Authors: Christos Panagiotis Lisgaras, Azahara Oliva, Sam Mckenzie, John LaFrancois, Steven A. Siegelbaum and Helen E. Scharman | Summary: Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures, abnormal activity between seizures, and impaired behavior. CA2 pyramidal neurons (PNs) are potentially important because inhibiting them with a chemogenetic approach […]