Multi-finger Receptive Field Properties in Primary Somatosensory Cortex: A Revised Account of the Spatio-Temporal Integration Functions of Area 3b

Posted by klaurent Hopkins

Kavli Affiliate: Charles Connor | Authors: Natalie K Trzcinski, Steven S Hsiao, Charles E Connor and Manuel Gomez-Ramirez | Summary: The leading view in the somatosensory system indicates that area 3b serves as a cortical relay site that encodes cutaneous (tactile) features limited to individual digits. Our recent work argues against this model by showing […]


Continue.. Multi-finger Receptive Field Properties in Primary Somatosensory Cortex: A Revised Account of the Spatio-Temporal Integration Functions of Area 3b

Interplay between rule learning and rule switching in a perceptual categorization task

Posted by klaurent UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Flora Bouchacourt, Sina Tafazoli, Marcelo Gomes Mattar, Timothy J Buschman and Nathaniel Douglass Daw | Summary: To adapt to a changing world, we must be able to switch between rules already learned and, at other times, learn rules anew. Often we must do both at the same time, switching […]


Continue.. Interplay between rule learning and rule switching in a perceptual categorization task

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terry Jernigan | Authors: Amirhossein Modabbernia, Didac Vidal-Pineiro, Ingrid Agartz, Ole A Andreassen, Rosa Ayesa-Arriola, Alessandro Bertolino, Dorret I Boomsma, Josiane Bourque, Alan Breier, Rachel M Brouwer, Jan K Buitelaar, Erick J Canales-Rodriguez, Xavier Caseras, Patricia J Conrod, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A Crone, Greig I de Zubicaray, Erin W Dickie, Danai […]


Continue.. Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets

Posted by klaurent UCSD / Salk

Kavli Affiliate: Angela Wu | Authors: Jia Zhao, Gefei Wang, Jingsi Ming, Zhixiang Lin, Yang Wang, The Tabula Microcebus Consortium, Angela Ruohao Wu and Can Yang | Summary: The rapid emergence of large-scale atlas-level single-cell RNA-seq datasets presents remarkable opportunities for broad and deep biological investigations through integrative analyses. However, harmonizing such datasets requires integration […]


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ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis

Posted by klaurent Yale

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Feinan Wu, Jessica Mariani, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Milovan Suvakov, Jeremy Schreiner, Yeongjun Jang, Cindy Khanh Nguyen, Elise M Cummings, Gloria Han, Kelly Powell, Anna Szekely, James C McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M Vaccarino | Summary: […]


Continue.. ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis

Persistent postnatal migration of interneurons into the human entorhinal cortex

Posted by klaurent UCSF

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Marcos Assis Nascimento, Sean Biagiotti, Vicente Herranz-Perez, Raymund Bueno, Chun Jimmie Ye, Taylor Abel, Juan S Rubio Moll, Jose Manuel Garcia-Verdugo, Eric J. Huang, Arturo Alvarez-Buylla and Shawn F Sorrells | Summary: The entorhinal cortex (EC) is a highly-interconnected hub for multisensory integration and memory processing1-3, containing diverse neuronal […]


Continue.. Persistent postnatal migration of interneurons into the human entorhinal cortex

KAT5 activity regulates G0-like states in human gliomas

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: Anca Mihalas, Sonali Arora, Samantha O’Connor, Heather Feldman, John Bassett, Kelly Mitchell, Kang Jin, Pia Hoellerbauer, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Bruce J Aronow, Christopher J Plaisier, Anoop Patel and PATRICK PADDISON | Summary: In solid tumors, G0-like cell populations likely play important roles […]


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Synergistic effect of mutations in the Parkinson’s disease-linked endocytic proteins synaptojanin 1 (PARK20) and auxilin (PARK19)

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically-enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and […]


Continue.. Synergistic effect of mutations in the Parkinson’s disease-linked endocytic proteins synaptojanin 1 (PARK20) and auxilin (PARK19)

Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer’s Disease

Posted by klaurent Hopkins, NTNU

Kavli Affiliate: Michael Miller, Susumu Mori, Menno Witter | Authors: Kaitlin Stouffer, Menno Witter, Claire Chen, Eileen Xu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael Miller | Summary: Since Braak’s initial histological observations, it has been recognized that Alzheimer’s disease (AD) neurofibrillary tangles (NFTs) appear in the medial temporal lobe (MTL) […]


Continue.. Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer’s Disease

Hypomyelination reduces parvalbumin interneuron density and auditory cortex inhibitory function

Posted by klaurent Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Beatriz C Borges, Xiangying Meng, Patrick Long, Patrick O Kanold and Gabriel Corfas | Summary: For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination focused primarily on excitatory cells. Recent evidence showed that axons of inhibitory neurons in the neocortex are […]


Continue.. Hypomyelination reduces parvalbumin interneuron density and auditory cortex inhibitory function