Kavli Affiliate: Li Zhao | Authors: Eric B Zheng and Li Zhao | Summary: Abstract De novo gene origination, where a previously non-genic genomic sequence becomes genic through evolution, has been increasingly recognized as an important source of evolutionary novelty across diverse taxa. Many de novo genes have been proposed to be protein-coding, and in […]
Kavli Affiliate: Li Zhao | Authors: Li Zhao, Ruhan Yi, Sun Liu, Yunliang Chi, Shengzhi Tan, Ji Dong, Hui Wang, Jing Zhang, Haoyu Wang, Xinping Xu, Binwei Yao, Bo Wang and Ruiyun Peng | Summary: Background Terahertz (THz) radiation is a valuable imaging and sensing tool which is widely used in industry and medicine. However, […]
Kavli Affiliate: Ann McDermott | Authors: Kelsey M McCoy and Ann E McDermott | Summary: FtsZ filaments are the major structural component of the bacterial Z-ring and are drivers of bacterial division. While crystal structures for FtsZ from some gram positive bacteria in the presence of GTP-analog like compounds suggest the possibility of a high […]
Kavli Affiliate: Vikaas Sohal | Authors: Kathleen Cho, Jingcheng Shi and Vikaas Singh Sohal | Summary: Changes in patterns of activity within the medial prefrontal cortex enable rodents, non-human primates, and humans to update their behavior to adapt to changes in the environment, e.g., during cognitive tasks1–5. Within medial prefrontal cortex, inhibitory neurons expressing parvalbumin […]
Kavli Affiliate: Kevin Bender, Jeanne Tamar Paz | Authors: Serena Tamura, Andrew D Nelson, Perry WE Spratt, Henry Kyoung, Xujia Zhou, Zizheng Li, Jingjing Zhao, Stephanie S Holden, Atehsa Sahagun, Caroline M Keeshen, Congyi Lu, Elizabeth C Hamada, Roy Ben-Shalom, Jen Q Pan, Jeanne T Paz, Stephan J Sanders, Navneet Matharu, Nadav Ahituv and Kevin […]
Kavli Affiliate: Pietro DeCamilli | Authors: Andrés Guillén Samander, Yumei Wu, S. Sebastian Pineda, Francisco J. García, Julia N. Eisen, Marianna Leonzino, Berrak Uğur, Manolis Kellis, Myriam Heiman and Pietro De Camilli | Summary: Chorea-acanthocytosis and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectively. Key features of […]
Kavli Affiliate: Patrick Kanold | Authors: Wenjun Shao, Minzi Chang, Kevin Emmerich, Patrick O Kanold, Jeff S Mumm and Ji Yi | Summary: Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make trade-offs […]
Kavli Affiliate: Patrick Kanold | Authors: Wenjun Shao, Minzi Chang, Kevin Emmerich, Patrick O Kanold, Jeff S Mumm and Ji Yi | Summary: Abstract Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make […]
Kavli Affiliate: Clifford Kentros | Authors: Thomas Doublet, Mona Nosrati and Clifford G. Kentros | Summary: Interactions between conspecifics are central to the acquisition of useful memories in the real world. Observational learning, i.e., learning a task by observing the success or failure of others, has been reported in many species, including rodents. However, previous […]
Kavli Affiliate: Kristofer Bouchard, Loren Frank | Authors: Oliver Rübel, Andrew Tritt, Ryan Ly, Benjamin K. Dichter, Satrajit Ghosh, Lawrence Niu, Ivan Soltesz, Karel Svoboda, Loren Frank and Kristofer E. Bouchard | Summary: The neurophysiology of cells and tissues are monitored electrophysiologically and optically in diverse experiments and species, ranging from flies to humans. Understanding […]