Kavli Affiliate: Jill Leutgeb | Authors: Mengni Wang, Li Yuan, Stefan Leutgeb and Jill K. Leutgeb | Summary: Mental exploration enables flexible evaluation of potential future choices, guiding decision-making without requiring direct real-world iterations. Although the hippocampus is known to be active while imagining the future, the precise mechanisms that support mental exploration of future […]
Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]
Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]
Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg and Michael N Shadlen | Summary: Confidence in a decision is the belief, prior to feedback, that one’s choice is correct. In the brain, many decisions are implemented as a race between competing evidence-accumulation processes. We ask whether the neurons that represent evidence accumulation also carry information […]
Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Bonhwang Koo, Marco Sollitto, Jennifer Balacco, Nadolina Brajuka, Richard Burhans, Erick Duarte, Alice Maria Giani, Kirsty McCaffrey, Jack A Medico, Eugene W Myers and Erich D Jarvis | Summary: Motivation Large sequencing data sets are produced and deposited into public archives at unprecedented rates. The availability of […]
Kavli Affiliate: Seth Shipman | Authors: Kazuo Nakamura, Karen Zhang, Mario R Mestre, Matias Rojas-Montero and Seth Shipman | Summary: Retrons are bacterial immune systems that protect a bacterial population against phages by killing infected hosts. Retrons typically comprise a reverse transcriptase, a template noncoding RNA that is partially reverse transcribed into RT-DNA, and a […]
Kavli Affiliate: Seth Blackshaw | Authors: Krishna Singh, yang jin, Mingwen Hu, Isabella Pallazo, Marisol Cano,, Thanh Hoang, Imran Bhutto, Shusheng Wang, Debasish Sinha, Seth Blackshaw, Jiang Qian and James T. Handa | Summary: Environmental exposure such as cigarette smoke induces epigenetic changes that can induce degenerative heterogeneity and accelerate aging. In early age-related macular […]
Kavli Affiliate: Kathleen Cullen | Authors: Hannah R Martin, Brandie Morris Verdone, Omar Lopez-Ramirez, Merrill Green, Dana Silvian, Emily Scott, Kathleen E Cullen and Ruth Anne Eatock | Summary: Vestibular hair cells (HCs) faithfully and rapidly detect head motions and gravity, driving motor reflexes that stabilize balance and gaze during locomotion. With the transition from […]
Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]
Kavli Affiliate: David Kleinfeld | Authors: Heet Kaku, Liu D Liu, Runbo Gao, Steven West, Song-Mao Liao, Arseny Finkelstein, David Kleinfeld, Alyse Thomas, Sri Laasya Tipparaju, Karel Svoboda and Nuo Li | Summary: Rhythmic orofacial movements, such as eating, drinking, or vocalization, are controlled by distinct premotor oscillator networks in the brainstem. Orofacial movements must […]