Machine-learning convergent melanocytic morphology despite noisy archival slides

Kavli Affiliate: Michael Keiser | Authors: Mikio Tada, Garrett Gaskins, Sina Ghandian, Nicholas Mew, Michael J. Keiser and Elizabeth S. Keiser | Summary: Melanocytic atypia, ranging from benign to malignant, often leads to diagnostic discordance, complicating its prediction by machine learning models. To overcome this, we paired H&E-stained histology images with contiguous or serial sections […]


Continue.. Machine-learning convergent melanocytic morphology despite noisy archival slides

3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Kavli Affiliate: Aniruddha Das | Authors: Jacqueline Salotti, Nida Asif, Srikanta Basu, Aniruddha Das, Mei Yang, Baktiar Karim, Karen Saylor, Nancy Martin, David A Scheiblin, Sweta Misra, Brian Luke, Thorkell Andresson, Stephen Lockett, Lino Tessarollo and Peter F Johnson | Summary: C/EBPβ is a potent regulator of oncogene-induced senescence (OIS) and the SASP. C/EBPβ is […]


Continue.. 3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Kavli Affiliate: John Serences | Authors: Rosanne L Rademaker and John Serences | Summary: People often remember visual information over brief delays while actively engaging with ongoing inputs from the surrounding visual environment. Depending on the situation, one might prioritize mnemonic contents (i.e., remembering details of a past event), or preferentially attend sensory inputs (i.e., […]


Continue.. Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Heterogeneous responses to embryonic critical period perturbations among different components of the Drosophila larval locomotor circuit

Kavli Affiliate: Michael Miller | Authors: Niklas Krick, Jacob Davies, Bramwell Coulson, Daniel Sobrido-Camean, Michael Miller, Matthew C.W. Oswald, Aref Arzan Zarin, Richard Baines and Matthias Landgraf | Summary: As developing neural circuits become functional, they undergo a phase of heightened plasticity in response to intrinsic and/or extrinsic stimuli. These developmental windows are termed critical […]


Continue.. Heterogeneous responses to embryonic critical period perturbations among different components of the Drosophila larval locomotor circuit

Exploiting correlations across trials and behavioral sessions to improve neural decoding

Kavli Affiliate: Liam Paninski | Authors: Yizi Zhang, Hanrui Lyu, Cole Hurwitz, Shuqi Wang, Charles Lincoln Findling, Felix Hubert, Alexandre Pouget, International Brain Laboratory, Erdem Varol and Liam Paninski | Summary: Traditional neural decoders model the relationship between neural activity and behavior within individual trials of a single experimental session, neglecting correlations across trials and […]


Continue.. Exploiting correlations across trials and behavioral sessions to improve neural decoding

Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

Kavli Affiliate: Charles M. Rice | Authors: Samantha G Muccilli, Bejamin Schwarz, Forrest Jessop, Jeffrey G. Shannon, Eric Bohrnsen, Byron Shue, Seon-Hui Hong, Thomas Hsu, Alison W. Ashbrook, Joseph W. Guarnieri, Justin Lack, Douglas C. Wallace, Catharine M. Bosio, Margaret R. MacDonald, Charles M Rice, Jonathan W Yewdell and Sonja M. Best | Summary: The […]


Continue.. Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

Learning-related oscillatory dynamics in the human cortico-basal ganglia network during motor sequence initiation in Parkinson’s Disease

Kavli Affiliate: Reza Abbasi Asl and Philip Starr | Authors: Kara N Presbrey, Thomas A Wozny, Kenneth H Louie, Simon Little, Philip A Starr, Reza Abbasi-Asl and Doris D Wang | Summary: Learning fine motor sequences is crucial to quality of life and can be altered in Parkinson’s Disease (PD). It may be partially driven […]


Continue.. Learning-related oscillatory dynamics in the human cortico-basal ganglia network during motor sequence initiation in Parkinson’s Disease

Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

Kavli Affiliate: Stefano Fusi and Michael Goldberg | Authors: Anna Ipata, Valeria Fascianelli, Chris I De Zeeuw, Naveen Sendhilnathan, Stefano Fusi and Michael E. Goldberg | Summary: Visuomotor association involves linking an arbitrary visual cue to a well-learned movement. Transient inactivation of Crus I/II impairs primates’ ability to learn new associations and delays motor responses […]


Continue.. Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

Neurovascular Impulse Response Function (IRF) during spontaneous activity differentially reflects intrinsic neuromodulation across cortical regions

Kavli Affiliate: David Kleinfeld | Bradley C. Rauscher, Natalie Fomin-Thunemann, Sreekanth Kura, Patrick R. Doran, Pablo D. Perez, Kıvılcım Kılıç, Emily A. Martin, Dora Balog, Nathan X. Chai, Francesca A. Froio, Patrick F. Bloniasz, Kate E. Herrema, Rockwell Tang, Scott G. Knudstrup, Andrew Garcia, John X. Jiang, Jeffrey P. Gavornik, David Kleinfeld, Michael E. Hasselmo, […]


Continue.. Neurovascular Impulse Response Function (IRF) during spontaneous activity differentially reflects intrinsic neuromodulation across cortical regions

Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Gohta Aihara, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics (SRO) technologies enable the identification of cell types while preserving their organization within tissues. Application of […]


Continue.. Characterizing cell-type spatial relationships across length scales in spatially resolved omics data