DARTsort: A modular drift tracking spike sorter for high-density multi-electrode probes

Kavli Affiliate: Liam Paninski | Authors: Julien Boussard, Charlie Windolf, Cole Hurwitz, Hyun Dong Lee, Han Yu, Olivier Winter and Liam Paninski | Summary: With the advent of high-density, multi-electrode probes, there has been a renewed interest in developing robust and scalable algorithms for spike sorting. Current spike sorting approaches, however, struggle to deal with […]


Continue.. DARTsort: A modular drift tracking spike sorter for high-density multi-electrode probes

Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells

Kavli Affiliate: Pietro De Camilli | Authors: Chase Amos, Peng Xu and Pietro De Camilli | Summary: Mutations of the bridge-like lipid transport protein VPS13A and of the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS) respectively, two similar conditions involving neurodegeneration and deformed erythrocytes (acanthocytes). VPS13A binds XK, suggesting a […]


Continue.. Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells

Sex Differences in Human Music Perception are Negligible

Kavli Affiliate: Sarah Woolley | Authors: Mila Bertolo, Daniel Müllensiefen, Isabelle Peretz, Sarah C. Woolley, Jon T. Sakata and Samuel A. Mehr | Summary: Since Darwin1, researchers have proposed that human musicality evolved in a reproductive context in which males produce music to signal their mate quality to females. Sexually selected traits involve tradeoffs in […]


Continue.. Sex Differences in Human Music Perception are Negligible

Xylem sap residue in cut-open conduits can affect gas discharge in pneumatic experiments

Kavli Affiliate: Gabriel Silva | Authors: Marcela Trevenzoli Miranda, Luciano Pereira, Gabriel Silva Pires, Xinyi Guan, Luciano Melo Silva, Swetlana Kreinert, Eduardo Caruso Machado, Steven Jansen and Rafael Ribeiro | Summary: Considerable progress has been made in understanding the mechanisms of embolism formation based on the pneumatic method, which relies on gas discharge measurements. Here, […]


Continue.. Xylem sap residue in cut-open conduits can affect gas discharge in pneumatic experiments

Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine

Kavli Affiliate: Alexandra Nelson, Robert Edwards | Authors: Shweta Jain, Andrew G Yee, James Maas, Sarah Gierok, Hongfei Xu, Jasmine Stansil, Jacob Eriksen, Alexandra Nelson, Katlin Silm, Christopher P Ford and Robert H Edwards | Summary: The burst firing of midbrain dopamine neurons releases a phasic dopamine signal that mediates reinforcement learning. At many synapses, […]


Continue.. Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine

Limitations of fluorescent timer proteins toward isolation of developmentally and transcriptionally synchronized populations of human pluripotent stem cells and neural progenitors highlight unique expression and fluorescence maturation kinetics by human cells

Kavli Affiliate: Seth Shipman | Authors: Manuel Peter, Seth Shipman, Jeffrey D. Macklis | Summary: Differentiation of human pluripotent stem cells (hPSC) into distinct neuronal populations holds substantial potential for disease modeling in vitro, toward both elucidation of pathobiological mechanisms and screening of potential therapeutic agents. For successful differentiation of hPSCs into subtype-specific neurons using […]


Continue.. Limitations of fluorescent timer proteins toward isolation of developmentally and transcriptionally synchronized populations of human pluripotent stem cells and neural progenitors highlight unique expression and fluorescence maturation kinetics by human cells

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

Kavli Affiliate: Seth Blackshaw | Authors: WPin Lyu, Maria Iribarne, Dmitri Serjanov, Yijie Zhai, Thanh Hoang, Leah J. Campbell, Patrick Boyd, Isabella Palazzo, Mikiko Nagashima, Nicholas J. Silva, Peter F. HItchcock, Jiang Qian, David R. Hyde and Seth Blackshaw | Summary: Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes. This […]


Continue.. Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

A semi-automated method for quantifying optokinetic reflex tracking acuity

Kavli Affiliate: Alex Kolodkin | Authors: James Kenneth Kiraly, Scott C Harris, Timour Al-Khindi, Felice Dunn and Alex L Kolodkin | Summary: The study of murine behavioral responses to visual stimuli is a key component of understanding mammalian visual circuitry. One notable response is the optokinetic reflex (OKR), a highly conserved innate behavior necessary for […]


Continue.. A semi-automated method for quantifying optokinetic reflex tracking acuity

SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

Kavli Affiliate: Richard Huganir | Authors: Yoichi Araki, Kacey E Rajkovich, Elizabeth E Gerber, Timothy R Gamache, Richard C Johnson, Thanh Hai Tran, Bian Liu, Ingie Hong, Alfredo Kirkwood and Richard L Huganir | Summary: SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in […]


Continue.. SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Maxime Fouyssac, Yvan M Vachez, Yifeng Cheng, Thibault Dufourd, Carole Carcenac, sabrina Boulet, Patricia H Janak, Marc Savasta, David Belin and Sebastien Carnicella | Summary: Impulse control disorders (ICDs), a wide spectrum of maladaptive behavior which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested […]


Continue.. Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks