Structured Joint Decomposition (SJD) identifies conserved molecular dynamics across collections of biologically related multi-omics data matrices

Posted by klaurent Hopkins

Kavli Affiliate: Brian Caffo | Authors: Huan Chen, Jinrui Liu, Shreyash Sonthalia, Genevieve Stein-OBrien, Luo Xiao, Brian Caffo and Carlo Colantuoni | Summary: Abstract Motivation It is necessary to develop exploratory tools to learn from the unprecedented volume of high-dimensional multi-omic data currently being produced. We have developed an R package, SJD, which identifies components […]


Continue.. Structured Joint Decomposition (SJD) identifies conserved molecular dynamics across collections of biologically related multi-omics data matrices

Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Paul L. Auer, Yasminka A Jakubek, Ying Zhou, Adrienne M Stilp, Jason Bacon, Justin Wong, Braxton Mitchell, Joshua Lewis, Eric Boerwinkle, Ruth J.F. Loos, Michael Preuss, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Edwin Silverman, Michael Cho, Jeong Yun, Vasan Ramachandran, […]


Continue.. Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing

Novel inhibitors against COVID-19 main protease suppressed viral infection

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Vijayan Ramachandran, Yanyun Liu, Qianying He, Andrew Tang, Patrick Ronaldson, Dominik Schenten and Rui Chang | Summary: Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can cause severe disease with high mortality rates, especially among older and vulnerable populations. Despite the recent success […]


Continue.. Novel inhibitors against COVID-19 main protease suppressed viral infection

Transcriptomic cytoarchitecture reveals principles of human neocortex organization

Posted by klaurent UCSD / Salk

Kavli Affiliate: Edward Callaway | Authors: Nikolas L. Jorstad, Jennie Close, Nelson Johansen, Anna Marie Yanny, Eliza R. Barkan, Kyle J. Travaglini, Darren Bertagnolli, Jazmin Campos, Tamara Casper, Kirsten Crichton, Nick Dee, Song-Lin Ding, Emily Gelfand, Jeff Goldy, Daniel Hirschstein, Matthew Kroll, Michael Kunst, Kanan Lathia, Brian Long, Naomi Martin, Delissa McMillen, Trangthanh Pham, Christine […]


Continue.. Transcriptomic cytoarchitecture reveals principles of human neocortex organization

Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens

Posted by klaurent UCSF

Kavli Affiliate: Joshua Berke | Authors: Ali Mohebi, Val L Collins and Joshua D Berke | Summary: Abstract Motivation to work for potential rewards is critically dependent on dopamine (DA) in the nucleus accumbens (NAc). DA release from NAc axons can be controlled by at least two distinct mechanisms: 1) action potentials propagating from DA […]


Continue.. Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens

Astrocyte-like CEPsh glia responds to stressful environments

Posted by klaurent UCSF

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, Noelle L’Etoile and RASHMI CHANDRA | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]


Continue.. Astrocyte-like CEPsh glia responds to stressful environments

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: Selim Chaib, José Alberto López-Domínguez, Marta Lalinde, Neus Prats, Inés Marín, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Marta Escorihuela, Sandra Pérez-Ramos, Fatima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, Joaquín Arribas and Manuel Serrano | Summary: Abstract Anti-cancer […]


Continue.. The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

Astrocyte-like CEPsh glia responds to the stressful environments

Posted by klaurent UCSF

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, RASHMI CHANDRA and Noelle L’Etoile | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]


Continue.. Astrocyte-like CEPsh glia responds to the stressful environments

Astrocyte-like CEPsh glia respond to stress

Posted by klaurent UCSF

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, Noelle L’Etoile and RASHMI CHANDRA | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]


Continue.. Astrocyte-like CEPsh glia respond to stress

Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease

Posted by klaurent Rockefeller

Kavli Affiliate: Charles Rice | Authors: Rachel Yamin, Kevin S Kao, Margaret R MacDonald, Tineke Cantaert, Charles M Rice, Jeffrey V Ravetch and Stylianos Bournazos | Summary: Abstract Although dengue virus (DENV) infection typically causes asymptomatic disease, DENV-infected patients can experience severe complications. A risk factor for symptomatic disease is pre-existing anti-DENV IgG antibodies. Cellular […]


Continue.. Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease