Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Multi-center integrated analysis of non-coding CRISPR screens

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: David Yao, Josh Tycko, Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunahi Luo, Keith Siklenka, Galip Gurkan Yardimci, The ENCODE4 Consortium, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis […]


Continue.. Multi-center integrated analysis of non-coding CRISPR screens

Single-cell RNA sequencing analyses of primary cutaneous B-cell disorders reveal distinct molecular patterns consistent with clinical behavior

Posted by klaurent NTNU

Kavli Affiliate: Vy Thuy Nguyen | Authors: Johannes Griss, Mathias C Drach, Vy Nguyen, Jasmine P Levine, Felix Thaler, Marco A Medjimorec, Lisa E Shaw, Ulrike Mann, Wolfgang Weninger, Christine Wagner, Stephan Wagner, Ingrid Simonitsch-Klupp, Matthias Farlik, Constanze Jonak and Patrick M Brunner | Summary: Cutaneous B-cell lymphomas (CBL) comprise a diverse group of diseases […]


Continue.. Single-cell RNA sequencing analyses of primary cutaneous B-cell disorders reveal distinct molecular patterns consistent with clinical behavior

Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements

Posted by klaurent UCSD / Salk

Kavli Affiliate: Eiman Azim | Authors: Morgan E Wirthlin, Tobias A. Schmid, Julie E. Elie, Xiaomeng Zhang, Varvara A. Shvareva, Ashley Rakuljic, Maria B. Ji, Ninad S. Bhat, Irene M. Kaplow, Daniel E. Schäffer, Alyssa J. Lawler, Siddharth Annaldasula, Byungkook Lim, Eiman Azim, Zoonomia Consortium, Wynn K. Meyer, Michael M. Yartsev and Andreas R. Pfenning […]


Continue.. Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements

Cellular and Fibrillar Collagen Analyses in an Animal Model of Retinal Detachment-Related Proliferative Vitreoretinopathy Reveals a Defined Transition to Chronic Fibrosis

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Cornelia Peterson, Clayton P. Santiago, Yuchen Lu, Antoinette Price, Minda M. McNally, William Schubert, Seth Blackshaw, Charles G. Eberhart and Mandeep S. Singh | Summary: SUMMARY Purpose Proliferative vitreoretinopathy (PVR) is the most common cause of failure of surgically repaired rhegmatogenous retinal detachment (RRD). Chemically-induced and cell-injection PVR models […]


Continue.. Cellular and Fibrillar Collagen Analyses in an Animal Model of Retinal Detachment-Related Proliferative Vitreoretinopathy Reveals a Defined Transition to Chronic Fibrosis

Functional network organization of the mouse cortex determined by wide-field fluorescence imaging shares some —but not all— properties revealed with simultaneous fMRI-BOLD

Posted by klaurent Yale

Kavli Affiliate: Michael Crair | Authors: Hadi Vafaii, Francesca Mandino, Gabriel Desrosiers-Gregoire, David O’Connor, Xilin Shen, Xinxin Ge, Peter Herman, Fahmeed Hyder, Xenophon Papademetris, Mallar Chakravarty, Michael Crair, Robert T Constable, Evelyn MR Lake and Luiz Pessoa | Summary: SUMMARY Understanding the organization of large-scale brain networks remains a central problem in neuroscience. Work in […]


Continue.. Functional network organization of the mouse cortex determined by wide-field fluorescence imaging shares some —but not all— properties revealed with simultaneous fMRI-BOLD

The TRPV Channel OSM-9 is Required for Sleep-Dependent Olfactory Memory and is Expressed in Sensory Neurons That Typically Do Not Promote Butanone Attraction

Posted by klaurent UCSF

Kavli Affiliate: Noelle Letoile, Saul Kato | Authors: Kelli L. Benedetti, Fatema A Saifuddin, Julia M Miller, Kevin Daigle, Rashmi Chandra, Alec Chen, Christine Lin, Angel Jacob Garcia, Burhanuddin Calcuttawala, Angelica Tovar, Raymond L Dunn, Jackson Borchardt, Julia A Kaye, Bo Zhang, Saul Kato, Maria E Gallegos, Torsten Wittmann and Noelle L’Etoile | Summary: SUMMARY […]


Continue.. The TRPV Channel OSM-9 is Required for Sleep-Dependent Olfactory Memory and is Expressed in Sensory Neurons That Typically Do Not Promote Butanone Attraction

Neural circuit-wide analysis of gene expression during deafening-induced destabilization of birdsong

Posted by klaurent UCSF

Kavli Affiliate: Michael Brainard | Authors: Bradley M Colquitt, Kelly Li, Foad Green, Robert J Veline and Michael S Brainard | Summary: SUMMARY Sensory feedback is required for stable execution of learned motor skills, and its loss can severely disrupt motor performance. The neural mechanisms that mediate sensorimotor stability have been extensively studied at systems […]


Continue.. Neural circuit-wide analysis of gene expression during deafening-induced destabilization of birdsong

Interactive auditory task reveals complex sensory-action integration in mouse primary auditory cortex

Posted by klaurent Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Ji Liu and Patrick O Kanold | Summary: SUMMARY Predictive coding theory postulates that the brain achieves perception by actively making predictions about the incoming sensory information and correcting them if errors signals arise. These signals are likely the most relevant when the individual is actively interacting with the […]


Continue.. Interactive auditory task reveals complex sensory-action integration in mouse primary auditory cortex

Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders

Posted by dbos Rockefeller

Kavli Affiliate: Timothy A. Ryan | Authors: Mukesh Kumar, Justin Knapp, Kallol Gupta and Timothy A Ryan | Summary: Recent advances have expanded the role of lipid droplets (LDs) beyond passive lipid storage, implicating their involvement in various metabolic processes across mammalian tissues. Neuronal LDs, long debated in existence, have been identified in several neural […]


Continue.. Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders