Neuroscience – Page 46 – Kavli Institute Pre-Print Publications

in silico transcriptome dissection of neocortical excitatory neurogenesis via joint matrix decomposition and transfer learning

Posted by dbos February 28, 2024March 11, 2024Hopkins

Kavli Affiliate: Brian Caffo | Authors: Shreyash Sonthalia, Guangyan Li, Xoel Mato Blanco, Alex Casella, Jinrui Liu, Genevieve Stein-O’Brien, Brian Caffo, Shaun Adkins, Joshua Orvis, Ronna Hertzano, Anup Mahurkar, Jesse A Gillis, Jonathan Werner, Shaojie Ma, Nicola Micali, Nenad Sestan, Pasko Rakic, Gabriel Santpere Baro, Seth A Ament and Carlo Colantuoni | Summary: The rising […]

Continue..

Deep phenotypic profiling of neuroactive drugs in larval zebrafish

Posted by dbos February 25, 2024March 4, 2024UCSF

Kavli Affiliate: Michael Keiser | Authors: Leo Gendelev, Jack Taylor, Douglas Myers-Turnbull, Steven Chen, Matthew N. McCarroll, Michelle R. Arkin, David Kokel and Michael J. Keiser | Summary: Behavioral larval zebrafish screens leverage a high-throughput small molecule discovery format to find neuroactive molecules relevant to mammalian physiology. We screened a library of 650 central nervous […]

Continue..

A series of spontaneously blinking dyes for super-resolution microscopy

Posted by dbos February 24, 2024March 4, 2024UCSD / Salk

Kavli Affiliate: Timothy Brown | Authors: Katie L. Holland, Sarah E. Plutkis, Timothy A. Daugird, Abhishek Sau, Jonathan B. Grimm, Brian P. English, Qinsi Zheng, Sandeep Dave, Fariha Rahman, Liangqi Xie, Peng Dong, Ariana N. Tkachuk, Timothy A. Brown, Robert H. Singer, Zhe J. Liu, Catherine G. Galbraith, Siegfried M. Musser, Wesley R. Legant and […]

Continue..

Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

Posted by dbos February 23, 2024March 4, 2024Yale

Kavli Affiliate: Anirvan Nandy | Authors: Xize Xu, Mitchell P Morton, Nyomi Hudson, Anirvan Nandy and Monika P. Jadi | Summary: Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. Yet how the spatial organization of objects influences neural activity in this hierarchy remains poorly understood. We […]

Continue..

The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

Posted by dbos February 23, 2024March 4, 2024UCSD / Salk

Kavli Affiliate: Li Zhao | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sayal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]

Continue..

The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

Posted by dbos February 23, 2024March 4, 2024Rockefeller

Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Nicolas Svetec, Henrik Molina and Li Zhao | Summary: Post-mating responses play a vital role in successful reproduction across diverse species. In fruit flies, sex peptide (SP) binds to sex peptide receptor (SPR), triggering a series of post-mating responses. However, the origin of SPR predates the emergence […]

Continue..

Rejuvenating silicon probes for acute electrophysiology

Posted by dbos February 23, 2024March 4, 2024Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Alden Shoup, Natasha Porwal, Mohammad Amin Fakharian, Paul Hage, Simon P Orozco and Reza Shadmehr | Summary: Electrophysiological recording with a new probe often yields better signal quality than with a used probe. Why does the signal quality degrade after only a few experiments? Here, we considered silicon probes […]

Continue..

Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

Posted by dbos February 23, 2024March 4, 2024UCSF

Kavli Affiliate: Alexandra Nelson | Authors: Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar and Alexandra B Nelson | Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination is […]

Continue..

C. elegans LIN-66 mediates EIF-3.G-dependent protein translation via a cold-shock domain

Posted by dbos February 22, 2024March 4, 2024UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Yishi Jin, Stephan M Blazie, Daniel Fortunati and Yan Zhao | Summary: Protein translation initiation is a complex and conserved process involving many proteins acting in concert. The eukaryotic initiation factor 3 (eIF3) complex is essential for the assembly of the pre-initiation complex that scans and positions mRNA at […]

Continue..

A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Posted by dbos February 22, 2024March 4, 2024Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Yaunlong Zhang, Lekang Yuan, Jiamin Wu, Tobias Noebauer, Rujin Zhang, Guihua Xiao, Mingrui Wang, Hao Xie, Qionghai Dai and Alipasha Vaziri | Summary: Understanding how neuronal dynamics gives rise to ethologically relevant behavior requires recording of neuronal population activity via technologies that are compatible with unconstrained animal behavior. However, […]

Continue..