A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

Posted by dbos UCSF

Kavli Affiliate: Joshua Berke | Authors: Mariana Duhne, Ali Mohebi, Kyoungjun Kim, Lilian Pelattini and Joshua D. Berke; | Summary: Movement, motivation and reward-related learning depend strongly on striatal dopamine and acetylcholine. These neuromodulators each regulate the other, and disturbances to their coordinated signals contribute to human disorders ranging from Parkinson’s Disease to depression and […]


Continue.. A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology

Posted by dbos UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Seungmee Park, Nathaniel Noblett, Lauren Pitts, Antonio Colavita, Ann M Wehman, Yishi Jin and Andrew D Chishol/p> | Summary: Mature neurons maintain their distinctive morphology for extended periods in adult life. Compared to developmental neurite outgrowth, axon guidance, and target selection, relatively little is known of mechanisms that maintain […]


Continue.. Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology

RealtimeDecoder: A fast software module for online clusterless decoding

Posted by dbos UCSF

Kavli Affiliate: Loren Frank | Authors: Joshua P Chu, Michael E Coulter, Eric L. Denovellis, Trevor TK Nguyen, Daniel F Liu, Xinyi Deng, Uri T Eden, Caleb T Kemere and Loren M Frank | Summary: Decoding algorithms provide a powerful tool for understanding the firing patterns that underlie cognitive processes such as motor control, learning, […]


Continue.. RealtimeDecoder: A fast software module for online clusterless decoding

Direct observation of the neural computations underlying a single decision

Posted by klaurent Columbia

Kavli Affiliate: Michael Shadlen | Authors: Natalie A Steinemann, Gabriel M Stine, Eric M Trautmann, Ariel Zylberberg, Daniel M Wolpert and Michael N Shadlen | Summary: Neurobiological investigations of perceptual decision-making have furnished the first glimpse of a flexible cognitive process at the level of single neurons (Shadlen and Newsome, 1996; Shadlen and Kiani, 2013). […]


Continue.. Direct observation of the neural computations underlying a single decision

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

Posted by dbos UCSF

Kavli Affiliate: Kira Poskanzer | Authors: Xuelong Mi, Alex Bo-Yuan Chen, Daniela Duarte, Erin Carey, Charlotte R. Taylor, Philipp N. Braaker, Mark Bright, Rafael G. Almeida, Jing-Xuan Lim, Virginia M. Rutten, Wei Zheng, Mengfan Wang, Michael E. Reitman, Yizhi Wang, Kira E. Poskanzer, David A. Lyons, Axel Nimmerjahn, Misha B. Ahrens and Guoqiang Yu | […]


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Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Anthony Dial Ramnauth, Madhavi Tippani, Heena R. Divecha, Alexis R. Papariello, Ryan A Miller, Erik D Nelson, Elizabeth A. Pattie, Joel E. Kleinman, Kristen R. Maynard, Leonardo Collado-Torres, Thomas M. Hyde, Keri Martinowich, Stephanie C Hicks and Stephanie Cerceo Page | Summary: The dentate gyrus of the hippocampus is […]


Continue.. Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region

Posted by dbos Columbia

Kavli Affiliate: Steven Siegelbaum | Authors: Andres Villegas and Steven A Siegelbaum | Summary: The dorsal CA2 subregion (dCA2) of the hippocampus exerts a critical role in social novelty recognition (SNR) memory and in the promotion of social aggression. Whether the social aggression and SNR memory functions of dCA2 are related or represent independent processes […]


Continue.. Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region

Two routes to value-based decisions in Parkinsons disease: differentiating incremental reinforcement learning from episodic memory

Posted by dbos Columbia

Kavli Affiliate: Daphna Shohamy | Authors: Peter Jendrichovsky, Hey-Kyoung Lee and Patrick O Kanold | Summary: Patients with Parkinsons disease are impaired at incremental reward-based learning. It is typically assumed that this impairment reflects a loss of striatal dopamine. However, many open questions remain about the nature of reward-based learning deficits in Parkinsons. Recent studies […]


Continue.. Two routes to value-based decisions in Parkinsons disease: differentiating incremental reinforcement learning from episodic memory

Dark exposure reduces high-frequency hearing loss in C57BL/6J mice

Posted by dbos Hopkins

Kavli Affiliate: Hey-Kyoung Lee and Patrick Kanold | Authors: Peter Jendrichovsky, Hey-Kyoung Lee and Patrick O Kanold | Summary: Plastic changes in the brain are primarily limited to early postnatal periods. Recovery of adult brain plasticity is critical for the effective development of therapies. A brief (1-2 week) duration of visual deprivation (dark exposure, DE) […]


Continue.. Dark exposure reduces high-frequency hearing loss in C57BL/6J mice

A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: John Serences | Authors: Anna Shafer-Skelton, Timothy F Brady and John T Serences | Summary: Understanding 3D representations of spatial information, particularly in naturalistic scenes, remains a significant challenge in vision science. This is largely because of conceptual difficulties in disentangling higher-level 3D information from co-occurring features and cues (e.g., the 3D shape […]


Continue.. A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex