Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Robert A Edwards, Michael J. Roach, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Joel Brame, Anna Heintz-Buschart, Timothy R Cavagnaro, Elizabeth A Dinsdale, Michael P Doane, Nico Eisenhauer, Grace Mitchell, Bibishan Rai, Sunita Ramesh and Martin F Breed | Summary: Microbiomes are critical to the […]


Continue.. Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes

Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen and Denis Wirtz | Summary: Methods for spatially resolved cellular profiling using thinly cut sections have enabled […]


Continue.. Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

Generative interpolation and restoration of images using deep learning for improved 3D tissue mapping

Kavli Affiliate: Denis Wirtz | Authors: Saurabh Joshi, André Forjaz, Kyu Sang Han, Yu Shen, Daniel Xenes, Jordan Matelsky, Brock Wester, Arrate Munoz-Barrutia, Ashley L Kiemen, Pei-Hsun Wu and Denis Wirtz | Summary: The development of novel imaging platforms has improved our ability to collect and analyze large three-dimensional (3D) biological imaging datasets. Advances in […]


Continue.. Generative interpolation and restoration of images using deep learning for improved 3D tissue mapping

Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

Kavli Affiliate: Stanley Prusiner | Authors: Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth and Carlo Condello | Summary: Down Syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among the complex clinical features including musculoskeletal, neurological and cardiovascular disabilities, […]


Continue.. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

Kavli Affiliate: Denis Wirtz | Authors: Ashleigh J Crawford, Adrian Johnston, Wenxuan Du, Eban A Hanna, David Schell, Zeqi Wan, Ting-Hsi Chen, Fan Wu, Kehan Ren, Yeongseo Lim, Praful R Nair and Denis Wirtz | Summary: Immune cell-mediated killing of cancer cells in a solid tumor is prefaced by a multi-step infiltration cascade of invasion, […]


Continue.. A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

Small extracellular vesicles promote stiffness-mediated metastasis

Kavli Affiliate: Denis Wirtz | Authors: Alexandra Sneider, Ying Liu, Bartholomew Starich, Wenxuan Du, Carolyn Marar, Najwa Faqih, Gabrielle E Ciotti, Joo Ho Kim, Sejal Krishnan, Salma Ibrahim, Muna Igboko, Alexus Locke, Daniel M Lewis, Hanna Hong, Michelle Karl, Raghav Vij, Gabriella C Russo, Praful R Nair, Estibaliz Gómez-de-Mariscal, Mehran Habibi, Arrate Munoz-Barrutia, Luo Gu, […]


Continue.. Small extracellular vesicles promote stiffness-mediated metastasis

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

Kavli Affiliate: Mark Ellisman | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform […]


Continue.. AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

A Novel Dual Probe-based Method for Mutation Detection using Isothermal Amplification

Kavli Affiliate: Michael Miller | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Cost efficient and rapid detection tools to detect mutations especially those linked to drug-resistance are important to address concerns of the rising multi-drug resistance infections. Here we integrated dual probes, namely a calibrator probe and an indicator probe, […]


Continue.. A Novel Dual Probe-based Method for Mutation Detection using Isothermal Amplification

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

Kavli Affiliate: Denis Wirtz | Authors: Geonhui Lee, Claudia Wong, Anna Cho, Junior J. West, Ashleigh J. Crawford, Gabriella C. Russo, Bishwa Ranjan Si, Jungwoo Kim, Lauren Hoffner, Cholsoon Jang, Moonjung Jung, Robert D. Leone, Konstantinos Konstantopoulos, Andrew J. Ewald, Denis Wirtz and Sangmoo Jeong | Summary: The loss of E-cadherin (E-cad), an epithelial cell […]


Continue.. Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

Comparative Single Cell Analysis of Transcriptional Bursting Reveals the Role of Genome Organization on de novo Transcript Origination

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Cong Li, Christopher B Langer, Nicolas Svetec and Li Zhao | Summary: Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single-cell RNA-sequencing (scRNA-Seq) studies. […]


Continue.. Comparative Single Cell Analysis of Transcriptional Bursting Reveals the Role of Genome Organization on de novo Transcript Origination