Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers using chemistry

Posted by dbos UCSD / Salk

Kavli Affiliate: Timothy Brown | Pratik Kumar, Alina Gutu, Amelia Waring, Timothy A Brown, Luke D Lavis and Alison G. Tebo | Summary: Chemigenetic tags are versatile labels for fluorescence microscopy that combine some of the advantages of genetically encoded tags with small molecule fluorophores. The Fluorescence Activating and absorbance Shifting Tags (FASTs) bind a […]


Continue.. Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers using chemistry

Pronounced early differentiation underlies zebra finch gonadal germ cell development

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | First 5 Authors: Matthew T Biegler, Kirubel Belay, Wei Wang, Christina Szi, Paul G Collier, Ji-Dung Luo, Bettina Haase, Gregory L. Gedman, Asha V. Sidhu, Elijah Harter, Carlos Rivera-Lopez, Kwame Amoako-Boadu, Olivier Fedrigo, Hagen U. Tilgner, Thomas T Carroll, Erich D. Jarvis and Anna L. Keyte | Summary: The diversity […]


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Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | First 5 Authors: Marc Duque, Alex B. Chen, Eric Hsu, Sujatha Narayan, Altyn Rymbek, Shahinoor Begum, Gesine Saher, Adam Ezra Cohen, David E. Olson, David A Prober, Dwight E Bergles, Mark C Fishman, Florian Engert and Misha B Ahrens | Summary: Mood-altering compounds hold promise for the treatment of many […]


Continue.. Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Effects of parental age and polymer composition on short tandem repeat de novo mutation rates

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Michael E Goldberg, Michelle D Noyes, Evan E Eichler, Aaron Quinlan and Kelley Harris | Summary: Short tandem repeats (STRs) are hotspots of genomic variability in the human germline because of their high mutation rates, which have long been attributed largely to polymerase slippage during DNA replication. This model […]


Continue.. Effects of parental age and polymer composition on short tandem repeat de novo mutation rates

Homological landscape of human brain functional sub-circuits

Posted by dbos UCSF

Kavli Affiliate: Alan David Kaplan | Authors: Duy Duong-Tran, Ralph Kaufmann, Jiong Chen, Xuan Wang, Sumita Garai, Frederick Xu, Jingxuan Bao, Enrico Amico, Alan David Kaplan, Giovanni Petri, Joaquin Goni, Yize Zhao and Li Shen | Summary: Human whole-brain functional connectivity networks have been shown to exhibit both local/quasilocal (e.g., set of functional sub-circuits induced […]


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Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Mikaela C Kasperek, Adriana Velasquez Galeas, Maria Elisa Caetano-Silva, Zifan Xie, Alexander V Ulanov, Michael R La Frano, Suzanne Devkota, Michael J Miller and Jacob M Allen | Summary: Ingestion of fermented foods impacts human immune function, yet the bioactive food components underlying these effects are not understood. Here, […]


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Neurotrophin NT-4/5 Promotes Structural Changes in Neurons of the Developing Visual Cortex

Posted by dbos UCSF

Kavli Affiliate: Michael Stryker | Authors: Antonella Antonini, Sheri L Harris and Michael P Stryker | Summary: Current hypotheses on the mechanisms underlying the development and plasticity of the ocular dominance system through competitive interactions between pathways serving the two eyes strongly suggest the involvement of neurotrophins and their high affinity receptors. In the cat, […]


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Circuit-motivated generalized affine models characterize stimulus-dependent visual cortical shared variability

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Ji Xia, Anna Jasper, Adam Kohn and Kenneth D Miller | Summary: Correlated variability in the visual cortex is modulated by stimulus properties. The stimulus dependence of correlated variability impacts stimulus coding and is indicative of circuit structure. An affine model combining a factor proportional to mean stimulus response […]


Continue.. Circuit-motivated generalized affine models characterize stimulus-dependent visual cortical shared variability

CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Isabel E Wassing, Atsuya Nishiyama, Moeri Hiruta, Qingyuan Jia, Reia Shikimachi, Amika Kikuchi, Keita Sugimura, Xin Hong, Yoshie Chiba, Junhui Peng, Christopher Jenness, Makoto Nakanishi, Li Zhao, Kyohei Arita and Hironori Funabiki | Summary: Mutations of the SNF2 family ATPase HELLS and its activator CDCA7 cause immunodeficiency-centromeric instability-facial anomalies […]


Continue.. CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Posted by dbos Rockefeller

Kavli Affiliate: Robert Edwards | Authors: R. Dilshan Malewana, Victoria Stalls, Aaron May, Xiaozhi Lu, David R Martinez, Alexandra Schafer, Dapeng Li, Maggie Barr, Laura L Sutherland, Esther Lee, Robert Parks, Whitney Edwards Beck, Amanda Newman, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, C. Todd DeMarco, Thomas N Denny, Thomas H Oguin III, Wes […]


Continue.. Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates