Kavli Affiliate: Jean Fan | Authors: Gohta Aihara, Kalen Clifton, Mayling Chen, Lyla Atta, Brendan F. Miller and Jean Fan | Summary: Motivation Spatial omics data demand computational analysis but many analysis tools have computational resource requirements that increase with the number of cells analyzed. This presents scalability challenges as researchers use spatial omics technologies […]
Kavli Affiliate: Denis Wirtz | Authors: Irfan S Kathiriya, Martin H Dominguez, Kavitha S Rao, Jonathan M. Muncie-Vasic, W. Patrick Devine, Kevin M. Hu, Swetansu K Hota, Bayardo I Garay, Diego Quintero, Piyush Goyal, Megan N Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah Winchester, Emily F Brower, André Forjaz, Pei-Hsun Wu, Denis Wirtz, Ashley […]
Kavli Affiliate: Vikram Chib | Authors: Aram Kim and Vikram S. Chib | Summary: Expectations as a reference point shape our decisions to motivate effortful activity. Despite the important role of reference points in human performance, little is known about how the brain processes expectations to guide motivated exertion. Participants completed a reward-based effort task […]
Kavli Affiliate: Brian Caffo Keri Martinowich | Authors: Jianing Yao, Jinglun Yu, Brian Caffo, Stephanie Cerceo Page, Keri Martinowich and Stephanie C Hicks | Summary: Recent advances in spatially-resolved single-omics and multi-omics technologies have led to the emergence of computational tools to detect or predict spatial domains. Additionally, histological images and immunofluorescence (IF) staining of […]
Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B. Kennedy | Summary: Activation of N-methyl-D-aspartate-type glutamate receptors (NMDARs) at synapses in the CNS triggers changes in synaptic strength that underlie memory formation in response to strong synaptic stimuli. The primary target of Ca2+ flowing through […]
Kavli Affiliate: Emre Yaksi | Authors: Percival P D’Gama, Inyoung Jeong, Andreas Moe Nygard, Ahmed Jamali, Emre Yaksi and Nathalie Jurisch-Yaksi | Summary: The brain uses a specialized system to transport cerebrospinal fluid (CSF). This system consists of interconnected ventricles lined by ependymal cells, which generate a directional flow upon beating of their motile cilia. […]
Kavli Affiliate: Stanislas Leibler | Authors: Pablo Sartori and Stanislas Leibler | Summary: One of the tenets of molecular biology is that dynamical transitions between three dimensional structures largely determine the function of individual proteins, as well as multi-protein assemblies. Therefore, it seems only natural that evolutionary analysis of proteins, presently based mainly on their […]
Kavli Affiliate: Li Zhao | Authors: Yuntao Yang, Yuhan Xie, Zhao Li, Chiamaka Diala, Meer Ali, Rongbin Li, Yi Xu, Albon Wu, Pora Kim, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao and W. Jim Zheng | Summary: Alternative splicing is an important cellular process in eukaryotes, altering pre-mRNA to yield multiple protein isoforms from a single […]
Kavli Affiliate: Brian Caffo Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Abstract Batch effects, undesirable sources of variability across multiple experiments, present significant challenges for scientific and clinical discoveries. Batch effects […]
Kavli Affiliate: James Knierim | Authors: Cheng Wang, Heekyung Lee, Geeta Rao and James J Knierim | Summary: Abstract Episodic memory involves the processing of spatial and temporal aspects of personal experiences. The lateral entorhinal cortex (LEC) plays an essential role in subserving memory. However, the specific mechanism by which LEC integrates spatial and temporal […]