Cilia-mediated cerebrospinal fluid flow modulates neuronal and astroglial activity in the zebrafish larval brain

Posted by dbos NTNU

Kavli Affiliate: Emre Yaksi | Authors: Percival P D’Gama, Inyoung Jeong, Andreas Moe Nygard, Ahmed Jamali, Emre Yaksi and Nathalie Jurisch-Yaksi | Summary: The brain uses a specialized system to transport cerebrospinal fluid (CSF). This system consists of interconnected ventricles lined by ependymal cells, which generate a directional flow upon beating of their motile cilia. […]


Continue.. Cilia-mediated cerebrospinal fluid flow modulates neuronal and astroglial activity in the zebrafish larval brain

Evolutionary conservation of mechanical strain distributions in functional transitions of protein structures

Posted by klaurent Rockefeller

Kavli Affiliate: Stanislas Leibler | Authors: Pablo Sartori and Stanislas Leibler | Summary: One of the tenets of molecular biology is that dynamical transitions between three dimensional structures largely determine the function of individual proteins, as well as multi-protein assemblies. Therefore, it seems only natural that evolutionary analysis of proteins, presently based mainly on their […]


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Systematic characterization of protein structural features of alternative splicing isoforms using AlphaFold 2

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Yuntao Yang, Yuhan Xie, Zhao Li, Chiamaka Diala, Meer Ali, Rongbin Li, Yi Xu, Albon Wu, Pora Kim, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao and W. Jim Zheng | Summary: Alternative splicing is an important cellular process in eukaryotes, altering pre-mRNA to yield multiple protein isoforms from a single […]


Continue.. Systematic characterization of protein structural features of alternative splicing isoforms using AlphaFold 2

When no answer is better than a wrong answer: a causal perspective on batch effects

Posted by dbos Hopkins

Kavli Affiliate: Brian Caffo Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Abstract Batch effects, undesirable sources of variability across multiple experiments, present significant challenges for scientific and clinical discoveries. Batch effects […]


Continue.. When no answer is better than a wrong answer: a causal perspective on batch effects

Multiplexing of temporal and spatial information in the lateral entorhinal cortex

Posted by dbos Hopkins

Kavli Affiliate: James Knierim | Authors: Cheng Wang, Heekyung Lee, Geeta Rao and James J Knierim | Summary: Abstract Episodic memory involves the processing of spatial and temporal aspects of personal experiences. The lateral entorhinal cortex (LEC) plays an essential role in subserving memory. However, the specific mechanism by which LEC integrates spatial and temporal […]


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Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations

Posted by dbos Hopkins

Kavli Affiliate: Jin Kang | Authors: Dapeng Xiong, Yunguang Qiu, Junfei Zhao, Yadi Zhou, Dongjin Lee, Shobhita Gupta, Mateo Torres, Weiqiang Lu, Siqi Liang, Jin Joo Kang, Charis Eng, Joseph Loscalzo, Feixiong Cheng and Haiyuan Yu | Summary: Abstract Human genome sequencing studies have identified numerous loci associated with complex diseases. However, translating human genetic […]


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Incorporation of a cost of deliberation time in perceptual decision making

Posted by dbos Columbia

Kavli Affiliate: Michael Shadlen | Authors: Shinichiro Kira, Ariel Zylberberg and Michael N Shadlen | Summary: Abstract Many decisions benefit from the accumulation of evidence obtained sequentially over time. In such circumstances, the decision maker must balance speed against accuracy, and the nature of this tradeoff mediates competing desiderata and costs, especially those associated with […]


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Spike transmission failures in axons from mouse cortical pyramidal neurons in vivo

Posted by dbos Columbia

Kavli Affiliate: Rafael Yuste | Authors: Netanel Ofer, Victor Hugo Cornejo and Rafael Yuste | Summary: Abstract The propagation of action potentials along axons is traditionally considered to be reliable, as a consequence of the high safety factor of action potential propagation. However, numerical simulations have suggested that, at high frequencies, spikes could fail to […]


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Aberrant hippocampal Ca2+ micro-waves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

Posted by dbos Columbia

Kavli Affiliate: Rafael Yuste | Authors: Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O’Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel and Tony Kelly | Summary: Abstract Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using […]


Continue.. Aberrant hippocampal Ca2+ micro-waves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

Multi-day Neuron Tracking in High Density Electrophysiology Recordings using EMD

Posted by klaurent Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Augustine Xiaoran Yuan, Jennifer I Colonell, Anna Lebedeva, Michael Okun, Adam Charles and Timothy D Harris | Summary: Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. New advances in high density extracellular electrophysiology recording probes, […]


Continue.. Multi-day Neuron Tracking in High Density Electrophysiology Recordings using EMD