Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: Cognitive impairment is a frequent non-motor symptom in Parkinson’s disease, and cortical Lewy pathology is strongly […]


Continue.. Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Reproducibility of in-vivo electrophysiological measurements in mice

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: The International Brain Laboratory, Kush Banga, Julius Benson, Niccolò Bonacchi, Sebastian A Bruijns, Rob Campbell, Gaëlle A Chapuis, Anne K Churchland, M Felicia Davatolhagh, Hyun Dong Lee, Mayo Faulkner, Fei Hu, Julia Hunterberg, Anup Khanal, Christopher Krasniak, Guido T Meijer, Nathaniel J Miska, Zeinab Mohammadi, Jean-Paul Noel, Liam Paninski, […]


Continue.. Reproducibility of in-vivo electrophysiological measurements in mice

Ancient midbrain inhibitory neurons control selective spatial attention

Posted by dbos Hopkins

Kavli Affiliate: Shreesh P. Mysore | Authors: Ninad B Kothari, Wen-Kai You, Arunima Banerjee, Qingcheng Zhang and Shreesh P Mysore | Summary: Animal behavior at any instant is guided by information from only a subset of the plethora of stimuli in their sensory environments. The neural circuit mechanisms that select a behaviorally relevant ‘target’ from […]


Continue.. Ancient midbrain inhibitory neurons control selective spatial attention

Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Kasey L Brida, Emily T Jorgensen, Robert A Phillips III, Catherine E Newman, Jennifer J Tuscher, Emily K Morring, Morgan E Zipperly, Lara Ianov, Kelsey D Montgomery, Madhavi Tippani, Thomas M Hyde, Kristen R Maynard, Keri Martinowich and Jeremy J Day | Summary: Drugs of abuse activate defined neuronal […]


Continue.. Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward

PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate

Posted by dbos UCSF

Kavli Affiliate: Su Guo | Authors: Xiang Zhao, Wang Yiqi, Ahmet Can Solak, Jason Garcia, Vincent Mouilleau, Xingye Chen, Christopher J Wilkinson, Loic Alain Royer, Zhiqiang Alain Dong and Su Guo | Summary: Vertebrate radial glia progenitors (RGPs), the principal neural stem cells, balance self-renewal and differentiation through asymmetric cell division (ACD), during which unequal […]


Continue.. PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate

Event structure sculpts neural population dynamics in the lateral entorhinal cortex

Posted by dbos NTNU

Kavli Affiliate: Edvard Moser and May-Britt Moser | Authors: Benjamin R Kanter, Christine M Lykken, May-Britt Moser and Edvard I. Moser | Summary: Our experience of the world is a continuous stream of events which must be segmented and organized simultaneously at multiple timescales. The neural mechanisms underlying this process remain unknown. Here, we simultaneously […]


Continue.. Event structure sculpts neural population dynamics in the lateral entorhinal cortex

Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

Posted by dbos Hopkins

Kavli Affiliate: Patrick Kanold | Authors: HiJee Kang, Travis Babola and Patrick O Kanold | Summary: Sensory information is represented by small neuronal ensembles in sensory cortices. Neuronal activity shows high trial-by-trial variability in that repeated presentation of the same stimulus, e. g., multiple presentations of the same sound activate differing ensembles in the auditory […]


Continue.. Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

Low-dimensional olfactory signatures of fruit ripening and fermentation

Posted by dbos UCSD / Salk

Kavli Affiliate: Tatyana Sharpee | Authors: Yuansheng Zhou, Thomas F O’Connell, Majid Ghaninia, Brian Smith, Elizabeth J Hong and Tatyana O Sharpee | Summary: Odors provide an important communication channel between plants and animals. Fruits, vital nutrient sources for animals, emit a complex array of monomolecular volatiles. Animals can use the structure of these mixtures […]


Continue.. Low-dimensional olfactory signatures of fruit ripening and fermentation

Posterior parietal cortex maps progress along routes sharing the same meta-structure

Posted by dbos UCSD / Salk

Kavli Affiliate: Douglas Nitz | Authors: Alexander B Johnson and Douglas A Nitz | Summary: Neurons of posterior parietal cortex were recorded as rats performed a working memory task within a network of intersecting paths. The specific routes utilized in task performance provided opportunity to contrast responses of posterior parietal cortex sub-populations to linear and […]


Continue.. Posterior parietal cortex maps progress along routes sharing the same meta-structure

Dopamine D1 receptor expression in dlPFC inhibitory parvalbumin neurons may contribute to higher visuospatial distractibility in marmosets versus macaques

Posted by dbos Yale

Kavli Affiliate: Anirvan Nandy | Authors: Mary Kate P Joyce, Tsvetoslav G Ivanov, Fenna Krienen, Jude Mitchell, Shaojie Ma, Wataru Inoue, Anirvan P Nandy, Dibyadeep Datta, Alvaro Duque, Jon I Arellano, Rahul Gupta, Guillermo Gonzalez-Burgos, David A Lewis, Nenad Sestan, Steven A McCarroll, Julio C Martinez-Trujillo, Seán Froudist-Walsh and Amy FT Arnsten | Summary: Marmosets […]


Continue.. Dopamine D1 receptor expression in dlPFC inhibitory parvalbumin neurons may contribute to higher visuospatial distractibility in marmosets versus macaques