Kavli Affiliate: Denis Wirtz | Authors: Bartholomew Starich, Fan Yang, Derin Tanrioven, Heng-Chung Kung, Joanne Baek, Praful R. Nair, Pratik Kamat, Nico Macaluso, Joon Eoh, Kyu Sang Han, Luo Gu, Sean Sun, Pei-Hsun Wu, Denis Wirtz and Jude M. Phillip | Summary: Cellular senescence is a major driver of aging and disease. Here we show […]
Kavli Affiliate: Anirvan Nandy | Authors: Anirban Das, Alec G. Sheffield, Anirvan S. Nandy and Monika P. Jadi | Summary: Adaptive information processing, comprised of local computations and their efficient routing, is crucial for flexible brain function. Spatial attention is a quintessential example of this adaptive process. It is critical for recognizing and interacting with […]
Kavli Affiliate: Erich Jarvis | Authors: Elena N Waidmann, Victor HY Yang, William C Doyle and Erich D Jarvis | Summary: Vocal communication is a major component of animal social behavior. Vocalizations can be learned or innate, and can convey a variety of signals, including territorial limits, the presence of predators, or courtship intent. Mouse […]
Kavli Affiliate: Erich Jarvis | Authors: César D M Vargas, Rajvi K Agravat, Elena N Waidmann, Christodoulos Bochalis, Hector Bermudez, Theodoros Giannakopoulos and Erich D Jarvis | Summary: Vocalization is a complex behavior ranging from fully innate to advanced vocal learning. Vocal learning species possess a vocal primary motor cortex (M1) region that makes direct […]
Kavli Affiliate: Liam Paninski Mark Churchland | Authors: Andrew J Zimnik, K. Cora Ames, Xinyue An, Laura Driscoll, Antonio H Lara, Abigail A Russo, Vladislav Susoy, John P Cunningham, Liam Paninski, Mark M Churchland and Joshua I Glaser | Summary: In many neural populations, the computationally relevant signals are posited to be a set of […]
Kavli Affiliate: Jean Fan | Authors: Gohta Aihara, Kalen Clifton, Mayling Chen, Lyla Atta, Brendan F. Miller and Jean Fan | Summary: Motivation Spatial omics data demand computational analysis but many analysis tools have computational resource requirements that increase with the number of cells analyzed. This presents scalability challenges as researchers use spatial omics technologies […]
Kavli Affiliate: Denis Wirtz | Authors: Irfan S Kathiriya, Martin H Dominguez, Kavitha S Rao, Jonathan M. Muncie-Vasic, W. Patrick Devine, Kevin M. Hu, Swetansu K Hota, Bayardo I Garay, Diego Quintero, Piyush Goyal, Megan N Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah Winchester, Emily F Brower, André Forjaz, Pei-Hsun Wu, Denis Wirtz, Ashley […]
Kavli Affiliate: Vikram Chib | Authors: Aram Kim and Vikram S. Chib | Summary: Expectations as a reference point shape our decisions to motivate effortful activity. Despite the important role of reference points in human performance, little is known about how the brain processes expectations to guide motivated exertion. Participants completed a reward-based effort task […]
Kavli Affiliate: Brian Caffo Keri Martinowich | Authors: Jianing Yao, Jinglun Yu, Brian Caffo, Stephanie Cerceo Page, Keri Martinowich and Stephanie C Hicks | Summary: Recent advances in spatially-resolved single-omics and multi-omics technologies have led to the emergence of computational tools to detect or predict spatial domains. Additionally, histological images and immunofluorescence (IF) staining of […]
Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B. Kennedy | Summary: Activation of N-methyl-D-aspartate-type glutamate receptors (NMDARs) at synapses in the CNS triggers changes in synaptic strength that underlie memory formation in response to strong synaptic stimuli. The primary target of Ca2+ flowing through […]