Kavli Affiliate: Hana El-Samad | Authors: Matthew S Kim, Hersh K Bhargava, Gavin E Shavey, Wendell A Lim, Hana El-Samad and Andrew H Ng | Summary: Chimeric antigen receptor (CAR) T cells have made a tremendous impact in the clinic, but potent signaling through the CAR can be detrimental to treatment safety and efficacy. The […]
Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Ryan J Farrell, Kirsten G Bredvik, Michael Blake Hoppa, S Thomas Hennegan, Timothy A Brown and Timothy A Ryan | Summary: The endoplasmic reticulum (ER) is an important regulator of Ca2+ in cells and dysregulation of ER calcium homeostasis can lead to numerous pathologies. Understanding how […]
Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]
Kavli Affiliate: Michael W. Young | Authors: Waruna Thotamune, Sithurandi Ubeysinghe, Kendra Kumar Shrestha, Mahmoud Elhusse Mostafa, Michael C Young and Ajith Karunarathne | Summary: Beta-adrenergic receptors (βARs) are G protein-coupled receptors (GPCRs) that mediate catecholamine-induced stress responses, such as heart rate increase and bronchodilation. In addition to signals from the cell surface, βARs also […]
Kavli Affiliate: Daniel Kronauer | Authors: Taylor Hart, Lindsey E. Lopes, Dominic D. Frank and Daniel J.C. Kronauer | Summary: While the neural basis of age-related decline has been extensively studied (1–3), less is known about changes in neural function during the pre-senescent stages of adulthood. Adult neural plasticity is likely a key factor in […]
Kavli Affiliate: David Linden | Authors: Jessie Benedict, Robert H. Cudmore, David J. Linden, Diarra Oden and Aleah Spruell | Summary: Mammalian parenting is an unusually demanding commitment. How did evolution co-opt the reward system to ensure parental care? Previous work has implicated the lateral habenula (LHb), an epithalamic nucleus, as a potential intersection of […]
Kavli Affiliate: Robert Edwards | Authors: Qianyi E Zhang, Jared Lindenberger, Ruth Parsons, Bhishem Thakur, Rob Parks, Chan Soo Park, Xiao Huang, Salam Sammour, Katarzyna Janowska, Taylor N Spence, Robert J. Edwards, Mitchell Martin, Wilton B Williams, Sophie Gobeil, David C Montefiori, Bette Korber, Kevin O’Neil Saunders, Barton F Haynes, Barton F. Haynes, Rory Henderson […]
Kavli Affiliate: Franck Polleux | Authors: Yusuke Hirabayashi, Tommy L Lewis, Jr., Yudan Du, Daniel M Virga, Aubrianna Decker, Giovanna Coceano, Jonatan Alvelid, Maela Paul, Stevie Hamilton, Parker Kneis, Yasufumi Takahashi, Jellert Gaublomme, Ilaria Testa and Franck Polleux | Summary: In neurons of the mammalian central nervous system (CNS), axonal mitochondria are thought to be […]
Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Kevin Christian Gonzalez, Deborah Li, Catalina Yang, Donald Holder, Natalie McClain, Guofeng Zhang, Stephen Evans, Maria Chavarha, Jane Yi, Christopher Makinson, Michael Lin, Attila Losonczy and Adrian Negrean | Summary: Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack […]
Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Taylor Hart and Daniel J.C. Kronauer | Summary: According to Mendel’s second law, chromosomes segregate randomly in meiosis. Non-random segregation is primarily known for cases of selfish meiotic drive in females, in which particular alleles bias their own transmission into the oocyte1,2. Here, we report a […]