Kavli Affiliate: Edward Chang | Authors: Vardhaan S Ambati, Amit S Persad, Jasleen Kaur, Sanjeev Herr, Emily Cunningham, Abraham Dada, Justyna O Ekert, Quinn Greicius, Alexander Silva, Paul McMillan Villalobos, Niels Olshausen, Youssef Sibih, Sena Oten, Hunter S. Yamada, Gray Umbach, Alexander A Aabedi, Wajd Al-Holou, Jacob Young, Madhumita Sushil, Edward F Chang, Mitchel S. […]
Kavli Affiliate: Su Guo | Authors: Krishnashish Bose, Su Guo and Karnika Bhardwaj | Summary: Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressing neurons in larval zebrafish and brain-wide calcium imaging under head-fixed, tail-free conditions, […]
Kavli Affiliate: Seth Blackshaw | Authors: Haley Appel, Rogger Carmen-Orozco, Clayton Santiago, Thanh Hoang and Seth Blackshaw | Summary: The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes […]
Kavli Affiliate: Nathaniel Sawtell | Authors: Krista E Perks, Mariela D Petkova, Salomon Z Muller, Michael Genecin, Adishree Ghatare, Richard Schalek, Yuelong Wu, Michal Januszewski, Viren Jain, Jeff W Lichtman, LF Abbott and Nathaniel B Sawtell | Summary: Transitive inference (TI) is a cognitive process in which decisions are guided by internal representations of abstract […]
Kavli Affiliate: Vincent Ferrera | Authors: Fabian A Munoz Silva, Greg Jensen, Maxwell Shinn, Yelda Alkan, John Murray, Herbert Terrace and Vincent P Ferrera | Summary: Transitive inference (TI) is a cognitive process in which decisions are guided by internal representations of abstract relationships. While the mechanisms underlying transitive learning have been well studied, the […]
Kavli Affiliate: Jeanne Paz | Authors: Jeremy B Ford, Olive N Tambou, Jarret AP Weinrich, Debleena Chatterjee, Allan Basbaum and Jeanne T. Paz | Summary: Central post-stroke pain (CPSP) is a highly distressing condition that develops in 50% of people who suffer a thalamic stroke, and is typically unresponsive to current clinical treatments. Hypoxic damage […]
Kavli Affiliate: Vikaas Sohal | Authors: Xiyu Zhu, Lara L. Hagopian, Kira E. Wallquist and Vikaas Singh Sohal | Summary: While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well understood. Furthermore, despite recent discoveries of long-range projections from neocortical […]
Kavli Affiliate: Cory Miller | Authors: Anand R Mysorekar, Anushka Vispute and Cory Miller | Summary: Prosocial behaviors, such as cooperation and food sharing, are critical for maintaining group cohesion in social species, yet the influence of transient physiological states on these behaviors remains poorly understood. This study investigates how short-term ecological factors impact social […]
Kavli Affiliate: Lily Jan and Yuh Nung Jan | Authors: Chin Fen Teo, Sami T Tuomivaara, Niek van Hilten, David Crottès, Yuh Nung Jan, Michael Grabe and Lily Y Jan | Summary: The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphatidylethanolamine mostly on the inner […]
Kavli Affiliate: Sarah Woolley | Authors: Logan S James, Sarah C Woolley, Jon T Sakata, Courtney B Hilton, Michael J Ryan and Samuel A Mehr | Summary: Many animals produce sounds during courtship, and receivers prefer some sounds over others. Shared ancestry and convergent evolution may generate similarities in preference across species and could underlie […]