Single-Neuron Encoding of Learnability in the Dorsal Anterior Cingulate Cortex

Posted by dbos Columbia

Kavli Affiliate: Vincent Ferrera and Jacqueline Gottlieb | Authors: Yuhao Jin, Greg Jensen, Vincent Ferrera and Jacqueline Gottlieb | Summary: In natural environments, associations that indicate true learnable regularities are intermixed with those that arise from random and ultimately unlearnable relationships between events. To efficiently allocate cognitive resources and avoid inferring spurious patterns, organisms must […]


Continue.. Single-Neuron Encoding of Learnability in the Dorsal Anterior Cingulate Cortex

Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Haley Appel, Rogger Carmen-Orozco, Clayton Santiago, Thanh Hoang and Seth Blackshaw | Summary: The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes […]


Continue.. Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Jingliang Simon Zhang, Brian Guy, Clayton P Santiago, Caterina Tiozzo, Meghana Sreenath, Ya-Wen Chen, Seth Blackshaw and Robert J Johnston, Jr | Summary: Retinal ganglion cells (RGCs) are the projection neurons that transmit visual information from the retina to the brain. In many species, a substantial proportion of RGCs […]


Continue.. Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids

Flexible Working Memory in the Peripheral Nervous System

Posted by dbos UCSD / Salk

Kavli Affiliate: Anastasia Kiyonaga | Authors: Sihan Yang, Yueying Dong and Anastasia Kiyonaga | Summary: Working memory (WM) representations that are distributed across the brain can be flexibly recruited to best guide behavior1–4. For instance, information may be represented relatively more strongly in visual cortex when a WM task requires fine visual detail, or more […]


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Determination of Aedes mosquito mating success by a rapidly-evolving female-controlled lock-and-key mechanism

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Madison M. Walker, Jacopo Razzauti, Anurag Sharma, H. Amalia Pasolli and Leslie B. Vosshall | Summary: Mosquitoes, the world’s deadliest animal, exemplify single-mating systems where females mate only once in their lifetime, making mate choice critically important for reproductive success and mosquito control. Despite this importance, […]


Continue.. Determination of Aedes mosquito mating success by a rapidly-evolving female-controlled lock-and-key mechanism

Central carbon metabolism switching in lytic versus temperate coral reef viral communities

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Jacob Kelman, Meena Khan, Chibundu Umunna, Russell Brainard, Grace Donohue, Robert A Edwards, Natalie A Falta, Emma E. George, Eleanor Gorham, Juris Grasis, Kevin Green, Andreas F Haas, Kimberly Halsey, Eric Hester, Summer Jacob, Aydin Loid Karatas, Yan Wei Lim, Mark Little, Stuart Sandin, Jessie Segnitz, Maya Serota, Natalia […]


Continue.. Central carbon metabolism switching in lytic versus temperate coral reef viral communities

Childhood brain tumours instruct cranial haematopoiesis and immunotolerance

Posted by dbos UCSF

Kavli Affiliate: Arnold R. Kriegstein | Authors: Elizabeth Alexandra Cooper, David A Posner, Colin Y. C Lee, Linda Hu, Sigourney Bonner, Jessica T Taylor, Oscar Baldwin, Rocio Jimenez-Guerrero, Katherine E Masih, Katherine Wickham Rahrmann, Jason Eigenbrood, Gina Ngo, Valar Nila Roamio Franklin, Clive D’Santos, Richard Mair, Thomas Santarius, Claudia Craven, Ibrahim Jalloh, Julia Moreno-Vicente, Timotheus […]


Continue.. Childhood brain tumours instruct cranial haematopoiesis and immunotolerance

Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Posted by dbos Hopkins

Kavli Affiliate: Alexander Szalay | Authors: Tricia R Cottrell, Jeffrey S Roskes, Michael Fotheringham, Emily Cohen, Boyang Zhang, Logan L Engle, Daphne Wang, Elizabeth Will, Joel C Sunshine, Daniel Jimenez-Sanchez, Zhen Zheng, Justina X Caushi, Jiajia Zhang, Nina D’Amiano, Julie Stein-Deutsch, Sonali Uttam, Katie Pirie, Darah Vlaminck, Michelle Mataj, Alexa Fiorante, Nicole Espinosa, Teodora Popa, […]


Continue.. Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Parker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Steven Boggess, Angelique De Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J Keiser, Jamie Ifkovits, Adam Yala and Martin Kampmann | Summary: High-throughput phenotypic screening has historically relied on manually […]


Continue.. Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Prashanthi Ravichandran, Svitlana V. Bach, Robert A. Phillips III, Madeline R. Valentine, Nicholas J. Eagles, Yufeng Du, Ishbel Del Rosario, Ryan A. Miller, Heena R. Divecha, Madhavi Tippani, Kelsey D. Montgomery, Joel E. Kleinman, Shizhong Han, Stephanie Cerceo Page III, Thomas M. Hyde, Leonardo Collado Torres, Alexis Battle, Keri […]


Continue.. Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens