Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

Kavli Affiliate: Kay Tye | Authors: Caroline Jia, Andrea Tran, Faith Aloboudi, Ella Say, Nick Thao, Christopher R. Lee, Kanha Batra, Amanda Nguyen, Aneesh Bal, Nathaniel N. Nono, Jeremy Delahanty, May G Chan, Laurel R. Keyes, Reesha R. Patel, Romy Wichmann, Felix Taschbach, Yulong Li, Marcus K. Benna, Talmo D Pereira, Hao Li and Kay […]


Continue.. Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

Kavli Affiliate: Tatyana Sharpee and Sreekanth Chalasani | Authors: Iulia Rusu, Zachary T Cecere, Javier J How, Kathleen T Quach, Eviatar Yemini, Tatyana O Sharpee and Sreekanth H Chalasani | Summary: Neurons represent changes in external and internal environments by altering their activity patterns. While coherent brain-wide patterns of neural activity have been observed in […]


Continue.. A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson’s disease

Kavli Affiliate: Philip Starr | Authors: Jin-Xiao Zhang, Clay Smyth, Md Fahim Anjum, Yue Leng, Andrew D. Krystal, Philip A. Starr and Simon Little | Summary: Sleep disturbance is involved in the progression of neurodegenerative diseases, but the neurophysiological mechanisms remain unclear in humans. We recorded sleep at home using portable polysomnography for multiple nights […]


Continue.. A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson’s disease

Working memory by distributed neural oscillators in a simple nervous system

Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: Working memory allows an animal to gather sensory evidence over time, integrate it with evolving internal needs, and make informed decisions about […]


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Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice

Kavli Affiliate: Pietro De Camilli | Authors: Peng Xu, Rubia Isler Mancuso, Marianna Leonzino, Caroline J Zeiss, Diane S Krause and Pietro De Camilli | Summary: VPS13 is the founding member of a family of proteins that mediate lipid transfer at intracellular membrane contact sites by a bridge-like mechanism. Mammalian genomes comprise 4 VPS13 genes […]


Continue.. Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice

An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks

Kavli Affiliate: Charles M. Rice | Authors: Matthew A Cattle, Lauren C Aguado, Samantha Sze, Dylan Yueyang Wang, Thales Papagiannakopoulos, Susan Smith, Charles M Rice, William Matthew Schneider and John T Poirier | Summary: Retrons are a retroelement class found in diverse prokaryotes that can be adapted to augment CRISPR-Cas9 genome engineering technology to efficiently […]


Continue.. An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks

Enhancer-driven regulatory network of forebrain human development provides insights into autism

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]


Continue.. Enhancer-driven regulatory network of forebrain human development provides insights into autism

Separable global and local beta burst dynamics in motor cortex of primates

Kavli Affiliate: Karunesh Ganguly | Authors: Preeya Khanna, behraz farrokhi, Hoseok Choi, Sandon Griffin, Ian Heimbuch, Lisa Novik, Katherina Thiesen, John H Morrison, Robert Morecraft and Karunesh Ganguly | Summary: Sensorimotor beta band oscillations are known to modulate during normal movement control and abnormal beta modulation is linked to pathological bradykinesia. However, the functional differences […]


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Seizure-induced Transient Disruptive Changes in Brain Microstructure

Kavli Affiliate: Anders Dale | Authors: Akihiro Takamiya, Frank Riemer, Vera Jane Erchinger, Max Korbmacher, Hauke Bartsch, Olga Therese Ousdal, Ivan Maximov, Anders Dale, Louise Emsell, Ketil Joachim Oedegaard, Ute Kessler and Leif Oltedal | Summary: A leading hypothesis for the mechanisms of electroconvulsive therapy (ECT) posits an initial disruptive effect followed by enhanced neuroplasticity. […]


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Diverse and Flexible Strategies Enable Successful Cooperation in Marmoset Dyads

Kavli Affiliate: Anirvan Nandy | Authors: Olivia C Meisner, Weikang Shi, Amrita Nair, Gargi Nandy, Monika P Jadi, Anirvan S Nandy and Steve W. C. Chang | Summary: In humans, cooperation relies on advanced social cognition, but the extent to which these mechanisms support cooperation in nonhuman primates remains unclear. To investigate this, we examined […]


Continue.. Diverse and Flexible Strategies Enable Successful Cooperation in Marmoset Dyads