Neuroscience – Page 4 – Kavli Institute Pre-Print Publications

Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

Posted by dbos December 12, 2024January 13, 2025UCSD / Salk

Kavli Affiliate: Eiman Azim | Authors: Jake Lustig, Alexander Lammers, Julia Kaiser, Payal Patel, Aidan Raghu, James M. Conner, Phong Nguyen, Eiman Azim and Vibhu Sahni | Summary: The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPN) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular delineation […]

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Proactive and reactive construction of memory-based preferences

Posted by dbos December 11, 2024January 13, 2025Columbia

Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Nathaniel D. Daw and Daphna Shohamy | Summary: We are often faced with decisions we have never encountered before, requiring us to infer possible outcomes before making a choice. Computational theories suggest that one way to make these types of decisions is by accessing and linking related […]

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Neural mechanisms underlying the effects of cognitive fatigue on physical effort-based decision-making Michael Dryzer and Vikram S. Chib

Posted by dbos December 11, 2024January 13, 2025Hopkins

Kavli Affiliate: Vikram Chib | Authors: Michael Dryzer and Vikram S. Chib | Summary: Fatigue is a state of exhaustion that influences our willingness to engage in effortful tasks. While both physical and cognitive exertion can cause fatigue, there is a limited understanding of how fatigue in one exertion domain (e.g., cognitive) affects decisions to […]

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An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

Posted by dbos December 11, 2024January 13, 2025Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Erik D. Nelson, Madhavi Tippani, Anthony D. Ramnauth, Heena R. Divecha, Ryan A. Miller, Nicholas J. Eagles, Elizabeth A. Pattie, Sang Ho Kwon, Svitlana V. Bach, Uma M. Kaipa, Jianing Yao, Joel E. Kleinman, Leonardo Collado-Torres, Shizhong Han, Kristen R. Maynard, Thomas M. Hyde, Keri Martinowich, Stephanie C. Page […]

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Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson’s Disease

Posted by dbos December 9, 2024January 13, 2025UCSF

Kavli Affiliate: Jeremy Willsey | Authors: Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, David B. Kastner, Aliza T. Ehrlich, Matthew W. State, A. Jeremy Willsey and Helen […]

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Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Posted by dbos December 9, 2024January 13, 2025Columbia

Kavli Affiliate: Liam Paninski | Authors: Stefano Fusi and Liam Paninski | Summary: The brain is highly structured both at anatomical and functional levels. However, within individual brain areas, neurons often exhibit very diverse and seemingly disorganized responses. A more careful analysis shows that these neurons can sometimes be grouped together into specialized subpopulations (categorical […]

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Convergence of autism proteins at the cilium

Posted by dbos December 5, 2024January 6, 2025UCSF

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Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

Posted by dbos December 4, 2024January 6, 2025UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Erin M Ritchie, Siming Zhong, Qianyi Pu, Yunbo Li, Binhai Zheng and Yishi Jin | Summary: The conserved MAP3K12/Dual Leucine Zipper Kinase (DLK) plays versatile roles in neuronal development, axon injury and stress responses, and neurodegeneration, depending on cell-type and cellular contexts. Emerging evidence implicates abnormal DLK signaling in […]

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How much is ‘enough’? Considerations for functional connectivity reliability in pediatric naturalistic fMRI

Posted by dbos December 2, 2024January 6, 2025UCSD / Salk

Kavli Affiliate: Deanna J. Greene and Jeremy Willsey | Authors: Shefali S. Rai, Kate J. Godfrey, Kirk Graff, Ryann Tansey, Daria Merrikh, Shelly Yin, Matthew Feigelis, Damion V. Demeter, Tamara Vanderwal, Deanna J. Greene and Signe L. Bray | Summary: functional connectivity (FC) measurements are important for robust and reproducible findings, yet pediatric functional magnetic […]

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Oxytocin receptor controls promiscuity and development in prairie voles

Posted by dbos December 2, 2024January 6, 2025UCSF

Kavli Affiliate: Devanand Manoli and Jeremy Willsey | Authors: Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt, Belinda Wang, Gina Williams, Shuyu Wang, Kara Quine, Rose D. Larios, Kimberly L. P. Long, Nerissa Hoglen, Bibi Alika Sulaman, Marie C. Heath, Michael Sherman, Robert Klinkel, Angela Cai, Denis Galo, Lizandro Chan Caamal, Nastacia L. Goodwin, Annaliese Beery, […]

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