Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli and Shawn Ferguson | Authors: Xinbo Wang, Peng Xu, Amanda Bentley-DeSousa, William Hancock-Cerutti, Shujun Cai, Benjamin T Johnson, Francesca Tonelli, Lin Shao, Gabriel Talaia, Dario R Alessi, Shawn M Ferguson and Pietro De Camilli | Summary: Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in […]


Continue.. Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

A distinctive subset of microglia positioned at the paraventricular zone are dedicated to cleaning the cerebrospinal fluid

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Guoyang Zhou, Jian He, Baojie Mao, Guo Cheng, Rui Zhang, Qiang Wang, Xiaoli Liu, Jiaxin Zheng, Ming Wang, Li Zhao, Peng Shi, Xiao Z Shen and Shu Wan | Summary: The interconnected ventricles in the central nervous system are filled with cerebrospinal fluid (CSF) which serves multifaceted roles including […]


Continue.. A distinctive subset of microglia positioned at the paraventricular zone are dedicated to cleaning the cerebrospinal fluid

Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Olivia V. Goldman, Alexandra E. DeFoe, Yanyan Qi, Yaoyu Jiao, Shih-Che Weng, Leah Houri-Zeevi, Priyanka Lakhiani, Takeshi Morita, Jacopo Razzauti, Adriana Rosas-Villegas, Yael N. Tsitohay, Madison M. Walker, Ben R. Hopkins, Mosquito Cell Atlas Consortium, Omar S. Akbari, Laura B. Duvall, Helen White-Cooper, Trevor R. Sorrells, Roshan Sharma, […]


Continue.. Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami, Nick Belenko, Griffin Dennis, Cuidong Wang, Maria Esterlita Siantoputri, Yurie Maeda, Christina Pressl and Nathaniel Heintz | Summary: Fluorescent imaging enables visualization of the specific molecules of interest with high contrast, and the use of multiple fluorophores in a single tissue sample allows visualization of complex […]


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Structural and Antigenic Characterization of Novel and Diverse Henipavirus Glycoproteins

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Aaron J. May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Moumita Dutta, Maggie Barr, Rob Parks, Amanda Newman, Xiao Huang, Kijun Song, Victor Ilevbare, Salam Sammour, Chan Soo Park, Radha Devkota Adhikari, Priyanka Devkota, Katarzyna Janowska, Yanshun Liu, Garrett Scapellato, Taylor N. Spence, Katayoun Mansouri, Robert J Edwards, […]


Continue.. Structural and Antigenic Characterization of Novel and Diverse Henipavirus Glycoproteins

Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila.

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Francisco Joaquín Tassara, Mariano Barella, Lourdes Simó, Mailen Folgueira, Micaela Rodríguez-Caron, Juan Ignacio Ispizua, Mark H. Ellisman, Horacio O. de la Iglesia, M. Fernanda Ceriani and Julián Gargiulo | Summary: In vivo imaging of dynamic sub-cellular brain structures in Drosophila melanogaster is key to understanding several phenomena in neuroscience. […]


Continue.. Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila.

An evolutionarily conserved role for separase in the regulation of nuclear lamins

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Francesca Cipressa, Gaelle Pennarun, Giuseppe Bosso, Serena Rosignoli, Liliana Tullo, Nadia Schiralli, Chiara Borghi, Alessandro Paiardini, Michael L Goldberg, Pascale Bertrand and Giovanni Cenci | Summary: Separase is a well conserved endopeptidase that facilitates sister chromatid separation at the metaphase-anaphase transition by cleaving cohesins. Beyond its role in chromosome […]


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Human precentral gyrus neurons link speech sequences from listening to speaking

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Duo Xu, Jason E Chung, Alexander B Silva, Quinn R Greicius, Sean L Metzger, Yizhen Zhang, Matthew K Leonard, Manish K Aghi, Shawn L Hervey-Jumper and Edward F Chang | Summary: Speech perception and production are interconnected processes, but the underlying neural mechanisms remain unclear. We investigated this relationship […]


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Neuromodulation in neural organoids with shell MEAs

Posted by dbos Hopkins

Kavli Affiliate: Brian Caffo | Authors: Chris Acha, Derosh George, Lauren C. Diaz, Ziwei Ouyang, Dowlette-Mary M. Alam El Din, Hrishikesh Surlekar, Babak Moghadas, Pratyush Sai R. Rayasam, Yu-Chiao Lai, Lena Smirnova, Brian S. Caffo, Erik C. Johnson and David H. Gracias | Summary: Neural organoids (NOs) have emerged as important tissue engineering models for […]


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No Disconnection Syndrome after Near-Complete Callosotomy

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Selin Bekir, Johanna L. Hopf, Theresa Paul, Valerie M. Wiemer, Tyler Santander, Henri E. Skinner, Anna Rada, Friedrich G. Woermann, Thilo Kalbhenn, Barry Giesbrecht, Christian G. Bien, Olaf Sporns, Michael S. Gazzaniga, Lukas J. Volz and Michael B. Miller | Summary: Much of the sensory-motor processing in the human […]


Continue.. No Disconnection Syndrome after Near-Complete Callosotomy