Scalable Human Cellular Models of Parkinson Disease Reveal A Druggable Link Between the Angiotensin Receptor 1 and Alpha-Synuclein Pathology

Posted by dbos UCSF

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Su Guo | Authors: Mathieu Daynac, Vincent Mouilleau, Yuxi Liu, Xiaoyu Yang, Yin Shen and Su Guo | Summary: Background Parkinson’s disease (PD) involves progressive loss of midbrain dopaminergic (mDA) neurons in the substantia nigra. No disease-modifying treatments exist, only […]


Continue.. Scalable Human Cellular Models of Parkinson Disease Reveal A Druggable Link Between the Angiotensin Receptor 1 and Alpha-Synuclein Pathology

CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction

Posted by dbos Hopkins

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Kathleen Cullen | Authors: Chenhao Bao, Robyn Mildren, Adam Charles and Kathleen E Cullen | Summary: Background Complex spikes (CSs) in cerebellar Purkinje cells convey unique signals complementary to Simple spike (SS) action potentials, but are infrequent and variable in […]


Continue.. CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction

The antiviral Interferon pathway drives astrocyte aging and motor decline

Posted by dbos UCSD / Salk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Nicola Allen and Eiman Azim | Authors: Lara Labarta-Bajo, Ayesha R Thanawalla, Irene L Gutierrez, Su May Lei Soe, Brent Y Chick, Ioanna Andritsogianni, Setareh Metanat, Diana C Hargreaves, Susan M Kaech, Eiman Azim and Nicola J Allen | Summary: […]


Continue.. The antiviral Interferon pathway drives astrocyte aging and motor decline

Shared striatal neurons exhibit context-specific dynamics for internally and externally driven actions

Posted by dbos Columbia

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Darcy Peterka and Rui Costa | Authors: Jan L. Klee, Sulekh Fernando-Peiris, Sahil Suresh, Ines Rodrigues-Vaz, Darcy S Peterka, Rui M. Costa, Vivek R. Athalye and Tanya Sippy | Summary: Animals can initiate movements either in response to external cues […]


Continue.. Shared striatal neurons exhibit context-specific dynamics for internally and externally driven actions

Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Posted by dbos UCSF

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: The global rise in human […]


Continue.. Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression

Posted by dbos UCSD / Salk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Kay Tye | Authors: Austin Coley, Kanha Batra, Jeremy Delahanty, Laurel Keyes, Rachelle Pamintuan, Assaf Ramot, Jim Hagemann, Christopher Lee, Vivian Liu, Harini Adivikolanu, Jianna Cressy, Caroline Jia, Francesca Massa, Deryn LeDuke, Moumen Gabir, Braa Durubeh, Lexe linderhof, Reesha Patel, […]


Continue.. Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression

Spatial deconstruction of the plasma membrane

Posted by dbos Rockefeller

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Roderick MacKinnon | Authors: Venkata Shiva Mandala, Chen Zhao, Qiuying Chen, Steven Gross, Jacob B Geri and Roderick MacKinnon | Summary: The plasma membrane of cells is known to be heterogeneous with regards to the spatial distribution of proteins and […]


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Early impairment in dentate pattern separation in a rodent model of temporal lobe epilepsy.

Posted by dbos UCSD / Salk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Jill Leutgeb | Authors: Laura A. Ewell, Ario Ramezani, Gabrielle Suarez, Veronica C. Piatti, Vicky Lam, Tatyana G. Mills, Anelah McGinness, Raafat Kuk, Mika Ukai, Anna-Lena Schlenner, Stefan Leutgeb and Jill K. Leutgeb | Summary: The dentate gyrus of the […]


Continue.. Early impairment in dentate pattern separation in a rodent model of temporal lobe epilepsy.

eIF2B Selectively Anchors and Activates Mutant KRAS

Posted by dbos UCSF

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Peter Walter | Authors: Hyungdong Kim, Shiqi Diao, Kwang-Jin Cho, Hyun-Ro Lee, Junchen Liu, Pascal Egea, Tatu Pantsar, Milla Kurki, Nour Ghaddar, Shuo Wang, Jia Yi Zou, Mehdi Amiri, Ritchel Gannaban, John F. Hancock, Kylie M Rice, Qiyun Deng, Atsuo […]


Continue.. eIF2B Selectively Anchors and Activates Mutant KRAS

Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex

Posted by dbos Hopkins

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: James Knierim | Authors: Gorkem Secer, Bharath Krishnan, Noah Cowan and James J Knierim | Summary: The brain relies on external landmarks to anchor internal spatial representations. The neural mechanisms underlying this process and the sources of landmark signals remain […]


Continue.. Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex