Neuroscience – Page 19 – Kavli Institute Pre-Print Publications

Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Posted by dbos February 5, 2025February 19, 2025UCSF

Kavli Affiliate: Michael Keiser | Authors: Parker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Steven Boggess, Angelique De Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J Keiser, Jamie Ifkovits, Adam Yala and Martin Kampmann | Summary: High-throughput phenotypic screening has historically relied on manually […]

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Separable Dorsal Raphe Dopamine Projections mediate the Facets of Loneliness-like state

Posted by dbos February 4, 2025February 10, 2025UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran, Faith Aloboudi, May G Chan, Enzo Peroni, Grace Pereira, Alba López-Moraga, Anna Pall é, Eyal Y Kimchi, Nancy Padilla-Coreano, Romy Wichmann and […]

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Mental exploration of future choices during immobility theta oscillations

Posted by dbos February 3, 2025February 10, 2025UCSD / Salk

Kavli Affiliate: Jill Leutgeb | Authors: Mengni Wang, Li Yuan, Stefan Leutgeb and Jill K. Leutgeb | Summary: Mental exploration enables flexible evaluation of potential future choices, guiding decision-making without requiring direct real-world iterations. Although the hippocampus is known to be active while imagining the future, the precise mechanisms that support mental exploration of future […]

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Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

Posted by dbos February 3, 2025February 10, 2025UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]

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Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

Posted by dbos February 2, 2025March 12, 2025UCSF

Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]

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Population Representation of the Confidence in a Decision in the Parietal Cortex

Posted by dbos February 2, 2025February 10, 2025Columbia

Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg and Michael N Shadlen | Summary: Confidence in a decision is the belief, prior to feedback, that one’s choice is correct. In the brain, many decisions are implemented as a race between competing evidence-accumulation processes. We ask whether the neurons that represent evidence accumulation also carry information […]

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Evaluation of sequencing reads at scale using rdeval

Posted by dbos February 1, 2025February 10, 2025Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Bonhwang Koo, Marco Sollitto, Jennifer Balacco, Nadolina Brajuka, Richard Burhans, Erick Duarte, Alice Maria Giani, Kirsty McCaffrey, Jack A Medico, Eugene W Myers and Erich D Jarvis | Summary: Motivation Large sequencing data sets are produced and deposited into public archives at unprecedented rates. The availability of […]

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Phage defense and genome editing using novel retrons sourced from isolated environmental bacteria

Posted by dbos January 29, 2025February 10, 2025UCSF

Kavli Affiliate: Seth Shipman | Authors: Kazuo Nakamura, Karen Zhang, Mario R Mestre, Matias Rojas-Montero and Seth Shipman | Summary: Retrons are bacterial immune systems that protect a bacterial population against phages by killing infected hosts. Retrons typically comprise a reverse transcriptase, a template noncoding RNA that is partially reverse transcribed into RT-DNA, and a […]

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Cigarette smoke and biological age induce degenerative heterogeneity in retinal pigment epithelium

Posted by dbos January 28, 2025February 10, 2025Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Krishna Singh, yang jin, Mingwen Hu, Isabella Pallazo, Marisol Cano,, Thanh Hoang, Imran Bhutto, Shusheng Wang, Debasish Sinha, Seth Blackshaw, Jiang Qian and James T. Handa | Summary: Environmental exposure such as cigarette smoke induces epigenetic changes that can induce degenerative heterogeneity and accelerate aging. In early age-related macular […]

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KV1.8 (Kcna10) potassium channels enhance fast, linear signaling in vestibular hair cells and facilitate vestibulomotor reflexes and balance

Posted by dbos January 28, 2025February 10, 2025Hopkins

Kavli Affiliate: Kathleen Cullen | Authors: Hannah R Martin, Brandie Morris Verdone, Omar Lopez-Ramirez, Merrill Green, Dana Silvian, Emily Scott, Kathleen E Cullen and Ruth Anne Eatock | Summary: Vestibular hair cells (HCs) faithfully and rapidly detect head motions and gravity, driving motor reflexes that stabilize balance and gaze during locomotion. With the transition from […]

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