Kavli Affiliate: Carey Priebe and Joshua Vogelstein | Authors: Qingyang Wang, Nadine Randel, Yijie Yin, Cameron Shand, Amy Strange, Michael Winding, Albert Cardona, Marta Zlatic, Joshua Vogelstein and Carey Priebe | Summary: The emerging electron microscopy connectome datasets provides connectivity maps of the brains at single cell resolution, enabling us to estimate various network statistics, […]
Kavli Affiliate: Liam Paninski | Authors: Han Yu, Hanrui Lyu, Ethan YiXun Xu, Charlie Windolf, Eric Kenji Lee, Fan Yang, Andrew M Shelton, Shawn Olsen, Sahar Minavi, Olivier Winter, The International Brain Laboratory, Eva L Dyer, Chandramouli Chandrasekaran, Nicholas A Steinmetz, Liam Paninski and Cole Hurwitz | Summary: Current electrophysiological approaches can track the activity […]
Kavli Affiliate: Xingde Li | Authors: Yongping Chen and Xingde Li | Summary: This study investigates the synthesis of pH-responsive, reversible nanocomposites comprising polystyrene sulfonate (PSS)-coated gold nanorods and poly(allylamine hydrochloride) (PAH)-coated gold nanorods, along with their optical properties. We observed a pH-dependent swelling/shrinking of the nanocomposites and a dramatic red-shift (~ 60 nm) of […]
Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Donald Kramer, Yu Shen, Habin Bea, Margarita Tsapatsis, Jianglu Ping, Vasco Queiroga, Kyu Sang Han, Saurabh Joshi, Casey Grubel, Maria L. Beery, Irina Kusmartseva, Mark A. Atkinson, Ashley L Kiemen and Denis Wirtz | Summary: Nuclear morphology is an indicator of cellular function and disease states, as […]
Kavli Affiliate: Seth Blackshaw | Authors: Leah J Elias, Harrison Khoo, Francois Kroll, Caroline Zhang, Soojung C Hur, Jason Rihel and Seth Blackshaw | Summary: While sleep deprivation broadly disrupts health and well-being, the neural and molecular mechanisms that signal increased sleep pressure remain poorly understood. A key obstacle to progress is the fact that […]
Kavli Affiliate: Damon Clark | Authors: Samuel Brudner, Baohua Zhou, Viraaj Jayaram, Gustavo Madeira Santana, Damon Clark and Thierry Emonet | Summary: Odor cues guide animals to food and mates. Different environmental conditions can create differently patterned odor plumes, making navigation more challenging. Prior work has shown that animals turn upwind when they detect odor […]
Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: Cell migration plays a key role in normal developmental programs and in disease, including immune responses, tissue repair, and metastasis. Unlike other cell functions, such as proliferation which can be studied using high-throughput assays, cell migration […]
Kavli Affiliate: Patrick Kanold | Authors: Kate Maximov and Patrick O. Kanold | Summary: Presbycusis, or age-related hearing loss, is caused by changes in both the peripheral and the central auditory system. Many of the peripheral structures that degrade with age have been identified and characterized, but there is still a dearth of information pertaining […]
Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to […]
Kavli Affiliate: Kevin Bender | Authors: Joshua D Garcia, Chenyu Wang, Ryan Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George, Roy Ben-Shalom, David H Hackos and Kevin J Bender | Summary: Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized […]