Neuroscience – Page 13 – Kavli Institute Pre-Print Publications

Mobius Assembly for Plant Systems highlights promoter-coding sequence terminator interaction in gene regulation

Posted by dbos September 21, 2024September 30, 2024Hopkins

Kavli Affiliate: Andreas Andreou | Authors: Elif Gediz Kocaoglan, Andreas Andreou, Jessica Nirkko, Marisol Ochoa-Villarreal, Gary Loake and Naomi Nakayama | Summary: Plants are the primary biological platforms for producing food, energy, and materials in agriculture; however, they remain a minor player in the recent synthetic biology-driven transformation in bioproduction. Molecular tools and technologies for […]

Continue..

Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

Posted by dbos September 20, 2024September 30, 2024Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Christa Whelan Habela, Shiyu Liu, Arens Taga, Raha Dastgheyb, Norman Haughey, Dwight E Bergles, Hongjun Song, Guo-Li Ming and Nicholas J. Maragakis | Summary: The chromosome 15q11.2 locus is deleted in 1.5% of patients with genetic epilepsy and confers a risk for intellectual disability and schizophrenia. Individuals with this […]

Continue..

Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Muller glia.

Posted by dbos September 19, 2024September 30, 2024Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Nguyet Le, Sherine Awad, Isabella Palazzo, Thanh Hoang and Seth Blackshaw | Summary: Retinal Müller glia in cold-blooded vertebrates can reprogram into neurogenic progenitors to replace neurons lost to injury, but mammals lack this ability. While recent studies have shown that transgenic overexpression of neurogenic bHLH factors and glial-specific […]

Continue..

Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

Posted by dbos September 19, 2024September 30, 2024UCSD / Salk

Kavli Affiliate: Sreekanth Chalasani | Authors: Jessica A Haley, Tianyi Chen, Mikio Aoi and Sreekanth H Chalasani | Summary: Decision-making is a ubiquitous component of animal behavior that is often studied in the context of foraging. Foragers make a series of decisions while locating food (food search), choosing between food types (diet or patch choice), […]

Continue..

Lateral prefrontal cortex controls interplay between working memory and actions

Posted by dbos September 18, 2024September 30, 2024UCSD / Salk

Kavli Affiliate: Anastasia Kiyonaga | Authors: Anastasia Kiyonaga, Jacob Miller and Mark D’Esposito | Summary: Humans must often keep multiple task goals in mind, at different levels of priority and immediacy, while also interacting with the environment. We might need to remember information for an upcoming task while engaged in more immediate actions. Consequently, actively […]

Continue..

Machine-learning convergent melanocytic morphology despite noisy archival slides

Posted by dbos September 17, 2024September 30, 2024UCSF

Kavli Affiliate: Michael Keiser | Authors: Mikio Tada, Garrett Gaskins, Sina Ghandian, Nicholas Mew, Michael J. Keiser and Elizabeth S. Keiser | Summary: Melanocytic atypia, ranging from benign to malignant, often leads to diagnostic discordance, complicating its prediction by machine learning models. To overcome this, we paired H&E-stained histology images with contiguous or serial sections […]

Continue..

3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Posted by dbos Columbia

Kavli Affiliate: Aniruddha Das | Authors: Jacqueline Salotti, Nida Asif, Srikanta Basu, Aniruddha Das, Mei Yang, Baktiar Karim, Karen Saylor, Nancy Martin, David A Scheiblin, Sweta Misra, Brian Luke, Thorkell Andresson, Stephen Lockett, Lino Tessarollo and Peter F Johnson | Summary: C/EBPβ is a potent regulator of oncogene-induced senescence (OIS) and the SASP. C/EBPβ is […]

Continue..

Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Posted by dbos September 16, 2024September 30, 2024UCSD / Salk

Kavli Affiliate: John Serences | Authors: Rosanne L Rademaker and John Serences | Summary: People often remember visual information over brief delays while actively engaging with ongoing inputs from the surrounding visual environment. Depending on the situation, one might prioritize mnemonic contents (i.e., remembering details of a past event), or preferentially attend sensory inputs (i.e., […]

Continue..

Heterogeneous responses to embryonic critical period perturbations among different components of the Drosophila larval locomotor circuit

Posted by dbos September 16, 2024September 30, 2024Hopkins

Kavli Affiliate: Michael Miller | Authors: Niklas Krick, Jacob Davies, Bramwell Coulson, Daniel Sobrido-Camean, Michael Miller, Matthew C.W. Oswald, Aref Arzan Zarin, Richard Baines and Matthias Landgraf | Summary: As developing neural circuits become functional, they undergo a phase of heightened plasticity in response to intrinsic and/or extrinsic stimuli. These developmental windows are termed critical […]

Continue..

Exploiting correlations across trials and behavioral sessions to improve neural decoding

Posted by dbos September 15, 2024September 23, 2024Columbia

Kavli Affiliate: Liam Paninski | Authors: Yizi Zhang, Hanrui Lyu, Cole Hurwitz, Shuqi Wang, Charles Lincoln Findling, Felix Hubert, Alexandre Pouget, International Brain Laboratory, Erdem Varol and Liam Paninski | Summary: Traditional neural decoders model the relationship between neural activity and behavior within individual trials of a single experimental session, neglecting correlations across trials and […]

Continue..