Reconstructing Waddington’s Landscape from Data

Kavli Affiliate: Eric D. Siggia | Authors: Dillon J. Cislo, M Joaquina Delás, James Briscoe and Eric D. Siggia | Summary: The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within developmental signaling networks that coordinate […]


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Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

Kavli Affiliate: Denis Wirtz | Authors: Devon E Mason, Megan Goeckel, Sebastian L Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A Burdick, Levi Wood, Brain Y Chow, Amber N Stratman and Joel D Boerckel | Summary: Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. […]


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Accessible, realistic genome simulation with selection using stdpopsim

Kavli Affiliate: Scott Small | Authors: Graham Gower, Nathaniel S. Pope, Murillo F. Rodrigues, Silas Tittes, Linh N. Tran, Ornob Alam, Maria Izabel Alves Cavassim, Peter D. Fields, Benjamin C. Haller, Xin Huang, Ben Jeffrey, Kevin Korfmann, Christopher C. Kyriazis, Jiseon Min, Ines Rebollo, Clara T Rehmann, Scott T. Small, Christopher C. R. Smith, Georgia […]


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Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Kavli Affiliate: Vikaas Sohal | Authors: Carlos Johnson-Cruz, Kathleen K.A. Cho and Vikaas S. Sohal | Summary: The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs. stable maintenance of different encodings contribute to behavioral adaptation. We addressed this […]


Continue.. Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Kavli Affiliate: Vikaas Sohal | Authors: Carlos Johnson-Cruz, Kathleen K.A. Cho and Vikaas S. Sohal | Summary: The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs. stable maintenance of different encodings contribute to behavioral adaptation. We addressed this […]


Continue.. Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Causal Dynamics of Social Gaze in Primate Prefrontal-Amygdala Networks Revealed by Dynamic Bayesian Modeling

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Siqi Fan, Olga Dal Monte, Monika Jadi, Steve Chang and Anirvan Nandy | Summary: Social gaze is a fundamental channel of primate communication, shaping dynamic interactions and fostering mutual understanding. While prior studies have mapped the behavioral correlates of social gaze across the prefrontal-amygdala circuits, the causal […]


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A Scalable Toolkit for Modeling 3D Surface-based Brain Geometry

Kavli Affiliate: Anders Dale and Lisa T. Eyler | Authors: Yanghee Im, Leila Nabulsi, Melody J.Y. Kang, Sophia I. Thomopoulos, Ana M. Diaz Zuluaga, Anders M. Dale, Andriana Karuk, Annabella Di Giorgio, Benson Mwangi, Boris Gutman, Bronwyn Overs, Carlos Lopez Jaramillo, Colm McDonald, Dan Stein, Dara M. Cannon, David Glahn, Diego Hidalgo-Mazzei, Diliana Pecheva, Dominik […]


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Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex

Kavli Affiliate: Alex Kolodkin and Solange Brown | Authors: Alan Y. Gutman-Wei, Sriram Sudarsanam, Alec G. Cabalinan, Naseer Shahid, Anny Shi, Luis E. Guzman Clavel, Sophia M. Spindler-Krage, Amit Agarwal, Alex L. Kolodkin and Solange P. Brown | Summary: The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased […]


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StCEL-based platform enables detection and sequencing of native sialoglycoRNA

Kavli Affiliate: Wei Min | Authors: Guang-Dong Zeng, Yun-Long Wang, Xu-Hui Chen, Yi Ma, Zhu Zhu, Huan-Lei Liu, Li-Yuan Fan, Hao Nan, Ziwaregul Nur, Min Wei, Xin-Yuan Liu, Li Yi, Jiu-Yu Jin, Yu-Song Cao, Meng-Bo Qiu, Wei-Peng Sun, Yang Bai, Quan-Bo Zhou, Guo-Qing Zhang, Jing-Feng Chen, Jie Shi, Jian Zheng, Yixuan Xie, Peng Li, Xiang-Bo […]


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Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation

Kavli Affiliate: Michael Beer | Authors: Jielin Yan, Hyein S. Cho, Renhe Luo, Michael A. Beer, Wei Li and Danwei Huangfu | Summary: Precise regulation of transcription factor (TF) expression is critical for maintaining cell identity, but studies on how graded expression levels affect cellular phenotypes are limited. To address this gap, we employed human […]


Continue.. Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation