Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to […]


Continue.. Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling

In-situ vs. ex-situ drivers of galaxy quenching: ubiquity of main sequence and critical black hole mass from the FLAMINGO simulation

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | First 5 Authors: Seunghwan Lim, Sandro Tacchella, Roberto Maiolino, Joop Schaye, Matthieu Schaller | Summary: Exploiting a large sample of 5.3 million galaxies with $M_ast,{=},10^{10-11},{rm M}_odot$ from the highest-resolution FLAMINGO simulation, we carry out a statistical analysis of quiescent and star-forming galaxies to explore quenching mechanisms. From redshift $z,{simeq},7$ to […]


Continue.. In-situ vs. ex-situ drivers of galaxy quenching: ubiquity of main sequence and critical black hole mass from the FLAMINGO simulation

Self Consistent Thermal Resummation: A Case Study of the Phase Transition in 2HDM

Posted by klaurent Chicago

Kavli Affiliate: Carlos E. M. Wagner | First 5 Authors: Pedro Bittar, Subhojit Roy, Carlos E. M. Wagner, , | Summary: An accurate description of the scalar potential at finite temperature is crucial for studying cosmological first-order phase transitions (FOPT) in the early Universe. At finite temperatures, a precise treatment of thermal resummations is essential, […]


Continue.. Self Consistent Thermal Resummation: A Case Study of the Phase Transition in 2HDM

Interference with Gravitational Instability: Hot and Fuzzy Dark Matter

Posted by klaurent Chicago

Kavli Affiliate: Wayne Hu | First 5 Authors: Rayne Liu, Wayne Hu, Huangyu Xiao, , | Summary: Wave or fuzzy dark matter produced with high momenta behaves in many ways like hot particle dark matter while also possessing seemingly different phenomenology due to wave interference. We develop wave perturbation theory to show that white noise […]


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Deciphering the Nature of Virgil: An Obscured AGN Lurking Within an Apparently Normal Lyman-α Emitter During Cosmic Reionization

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | First 5 Authors: Pierluigi Rinaldi, Pablo G. Pérez-González, George H. Rieke, Jianwei Lyu, Francesco D’Eugenio | Summary: We present a comprehensive analysis of the MIRI Extremely Red Object Virgil, a Lyman-$alpha$ emitter at $z_{spec} = 6.6379 pm 0.0035$ with the photometric properties of a Little Red Dot. Leveraging new JWST/MIRI […]


Continue.. Deciphering the Nature of Virgil: An Obscured AGN Lurking Within an Apparently Normal Lyman-α Emitter During Cosmic Reionization

US National Input to the European Strategy Update for Particle Physics

Posted by klaurent Tokyo

Kavli Affiliate: Hitoshi Murayama | First 5 Authors: André de Gouvêa, Hitoshi Murayama, Mark Palmer, Heidi Schellman, | Summary: In this document we summarize the output of the US community planning exercises for particle physics that were performed between 2020 and 2023 and comment upon progress made since then towards our common scientific goals. This […]


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Sub-second spin and lifetime-limited optical coherences in $^{171}$Yb$^{3+}$:CaWO$_4$

Posted by klaurent Caltech

Kavli Affiliate: Andrei Faraon | First 5 Authors: Alexey Tiranov, Emanuel Green, Sophie Hermans, Erin Liu, Federico Chiossi | Summary: Optically addressable solid-state spins have been extensively studied for quantum technologies, offering unique advantages for quantum computing, communication, and sensing. Advancing these applications is generally limited by finding materials that simultaneously provide lifetime-limited optical and […]


Continue.. Sub-second spin and lifetime-limited optical coherences in $^{171}$Yb$^{3+}$:CaWO$_4$

Versatile silicon integrated photonic processor: a reconfigurable solution for netx-generation AI clusters

Posted by klaurent Tokyo

Kavli Affiliate: Jia Liu | First 5 Authors: Ying Zhu, Yifan Liu, Xinyu Yang, Kailai Liu, Xin Hua | Summary: The Artificial Intelligence models pose serious challenges in intensive computing and high-bandwidth communication for conventional electronic circuit-based computing clusters. Silicon photonic technologies, owing to their high speed, low latency, large bandwidth, and complementary metal-oxide-semiconductor compatibility, […]


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Flexible and Explainable Graph Analysis for EEG-based Alzheimer’s Disease Classification

Posted by klaurent Peking

Kavli Affiliate: Jing Wang | First 5 Authors: Jing Wang, Jun-En Ding, Feng Liu, Elisa Kallioniemi, Shuqiang Wang | Summary: Alzheimer’s Disease is a progressive neurological disorder that is one of the most common forms of dementia. It leads to a decline in memory, reasoning ability, and behavior, especially in older people. The cause of […]


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Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

Posted by klaurent UCSF

Kavli Affiliate: Kevin Bender | Authors: Joshua D Garcia, Chenyu Wang, Ryan Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George, Roy Ben-Shalom, David H Hackos and Kevin J Bender | Summary: Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized […]


Continue.. Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability