Kavli Affiliate: Timothy A. Ryan | Camila Pulido, Matthew S. Gentry and Timothy A. Ryan | Summary: The brain is a metabolically vulnerable organ as neurons have both high resting metabolic rates and the need for local rapid conversion of carbon sources to ATP during activity. Midbrain dopamine neurons are thought to be particularly vulnerable […]
Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: In auditory cortex, neural responses to stimuli inside receptive fields (RFs) can be further facilitated by behavioral demands, such as attending to a spatial location. It is less clear how off-RF stimuli modulate neural responses and contribute to […]
Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: Intelligent behavior necessitates an adaptive integration of feedback. It is well-known that animals asymmetrically learn from positive and negative feedback. While asymmetrical learning is a robust behavioral effect, the latent computations behind how animals represent their environments and […]
Kavli Affiliate: Michael W. Young | Zheng Zhang, Milo White, Jennifer A Kim, Victor M Torres-Lopez, Aya Khalaf, David Jin, Aaron D Boes, Brian L Edlow, Stephen W English, David Fischer, Joel Geerling, Saleem M Halablab, Maarten G Lansberg, Margy McCullough-Hicks, James F Meschia, Patrik L Michel, Paola Palazzo, Benjamin D Reasoner, Robert W Regenhardt, […]
Kavli Affiliate: Frank W. Wise | First 5 Authors: Varun Sharma, Varun Sharma, , , | Summary: While nonlinear effects in graded-index (GRIN) multimode fibers have been studied extensively, little is known about nonlinear effects in larger GRIN waveguides, where the number of modes approaches infinity and modal dispersion becomes negligible. Here we show that […]
Kavli Affiliate: David T. Limmer | First 5 Authors: Jorge L. Rosa-Raíces, Jorge L. Rosa-Raíces, , , | Summary: We propose a method to compute free-energy differences from nonadiabatic alchemical transformations using flow-based generative models. The method, nonadiabatic force matching, hinges on estimating the dissipation along an alchemical switching process in terms of a nonadiabatic […]
Kavli Affiliate: David T. Limmer | First 5 Authors: Jorge L. Rosa-Raíces, Jorge L. Rosa-Raíces, , , | Summary: We propose a method to compute free energies from nonadiabatic alchemical transformations using diffusion-denoising generative models. The method, nonadiabatic force matching, hinges on estimating — rather than minimizing — the dissipation along an alchemical transition as […]
Kavli Affiliate: Marshall W. Bautz | First 5 Authors: Abigail Y. Pan, Abigail Y. Pan, , , | Summary: The Advanced X-ray Imaging Satellite (AXIS) is one of two candidate mission concepts selected for Phase-A study for the new NASA Astrophysics Probe Explorer (APEX) mission class, with a planned launch in 2032. The X-ray camera […]
Kavli Affiliate: Gregory Prigozhin | First 5 Authors: Abigail Y. Pan, Abigail Y. Pan, , , | Summary: The Advanced X-ray Imaging Satellite (AXIS) is one of two candidate mission concepts selected for Phase-A study for the new NASA Astrophysics Probe Explorer (APEX) mission class, with a planned launch in 2032. The X-ray camera for […]
Kavli Affiliate: Marshall W. Bautz | First 5 Authors: Catherine E. Grant, Catherine E. Grant, , , | Summary: The Advanced X-ray Imaging Satellite (AXIS), an astrophysics NASA probe mission currently in phase A, will provide high-throughput, high-spatial resolution X-ray imaging in the 0.3 to 10 keV band. We report on the notional ground calibration […]