September 25, 2025 – Kavli Institute Pre-Print Publications

Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Posted by dbos September 25, 2025October 7, 2025Hopkins

Kavli Affiliate: Alexander Szalay | Authors: Tricia R Cottrell, Jeffrey S Roskes, Michael Fotheringham, Emily Cohen, Boyang Zhang, Logan L Engle, Daphne Wang, Elizabeth Will, Joel C Sunshine, Daniel Jimenez-Sanchez, Zhen Zheng, Justina X Caushi, Jiajia Zhang, Nina D’Amiano, Julie Stein-Deutsch, Sonali Uttam, Katie Pirie, Darah Vlaminck, Michelle Mataj, Alexa Fiorante, Nicole Espinosa, Teodora Popa, […]

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Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Posted by dbos September 25, 2025October 7, 2025UCSF

Kavli Affiliate: Michael Keiser | Authors: Parker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Steven Boggess, Angelique De Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J Keiser, Jamie Ifkovits, Adam Yala and Martin Kampmann | Summary: High-throughput phenotypic screening has historically relied on manually […]

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A nearly pristine star from the Large Magellanic Cloud

Posted by klaurent September 25, 2025Chicago

Kavli Affiliate: Alexander Ji | Summary:The first stars formed out of pristine gas, causing them to be so massive that none are expected to have survived until today. If their direct descendants were sufficiently low-mass stars, such stars could exist today and would be recognizable by having the lowest metallicities (abundance of elements heavier than […]

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A nearly pristine star from the Large Magellanic Cloud

Posted by klaurent September 25, 2025October 7, 2025Chicago

Kavli Affiliate: Alexander P. Ji | First 5 Authors: Alexander P. Ji, Alexander P. Ji, , , | Summary: The first stars formed out of pristine gas, causing them to be so massive that none are expected to have survived until today. If their direct descendants were sufficiently low-mass stars, they could exist today and […]

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Limb Asymmetries on WASP-39b: A Multi-GCM Comparison of Chemistry, Clouds, and Hazes

Posted by klaurent September 25, 2025Caltech

Kavli Affiliate: Nathan S. Lewis| First 5 Authors: Maria E. Steinrueck, Maria E. Steinrueck, , , | Summary:With JWST, observing separate spectra of the morning and evening limbs of hot Jupiters has finally become a reality. The first such observation was reported for WASP-39b, where the evening terminator was observed to have a larger transit […]

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BlackTHUNDER: Evidence of three massive black holes in a z~5 galaxy

Posted by klaurent September 25, 2025Cambridge

Kavli Affiliate: Roberto Maiolino | Summary:We present observational evidence of three massive, accreting black holes (BHs) in the z=5.0167 galaxy J0148-4214 from JWST/NIRSpec-IFU spectroscopy. The BHs are revealed through broad H$α$ emission (FWHM=430-2920 km/s) without a forbidden-line counterpart in the bright [OIII] doublet. Channel maps of the asymmetric central H$α$ profile isolate two spatially distinct […]

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BlackTHUNDER: evidence for three massive black holes in a z~5 galaxy

Posted by klaurent September 25, 2025Cambridge

Kavli Affiliate: Debora Sijacki | Summary:We present observational evidence for three massive, accreting black holes in the $z=5.0167$ galaxy J0148-4214 from JWST/NIRSpec-IFU spectroscopy. The black holes are revealed through broad H$α$ emission (FWHM = 430-2920 km/s) without a forbidden-line counterpart in the bright [O III] doublet. Channel maps of the asymmetric central H$α$ profile isolate […]

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Electrostatic waves in astrophysical Druyvesteyn plasmas: I. Langmuir waves

Posted by klaurent September 25, 2025Stanford

Kavli Affiliate: Dustin M. Schroeder| First 5 Authors: Simon Tischmann, Simon Tischmann, , , | Summary:Plasmas in various astrophysical systems are in non-equilibrium states as evidenced by direct in-situ measurements in the solar wind, solar corona and planetary environments as well as by indirect observations of various sources of waves and emissions in astrophysical systems. […]

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Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

Posted by dbos September 25, 2025October 7, 2025Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Prashanthi Ravichandran, Svitlana V. Bach, Robert A. Phillips III, Madeline R. Valentine, Nicholas J. Eagles, Yufeng Du, Ishbel Del Rosario, Ryan A. Miller, Heena R. Divecha, Madhavi Tippani, Kelsey D. Montgomery, Joel E. Kleinman, Shizhong Han, Stephanie Cerceo Page III, Thomas M. Hyde, Leonardo Collado Torres, Alexis Battle, Keri […]

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MMR1: Enhancing Multimodal Reasoning with Variance-Aware Sampling and Open Resources

Posted by klaurent September 25, 2025October 7, 2025Peking

Kavli Affiliate: Jing Wang | First 5 Authors: Sicong Leng, Sicong Leng, , , | Summary: Large multimodal reasoning models have achieved rapid progress, but their advancement is constrained by two major limitations: the absence of open, large-scale, high-quality long chain-of-thought (CoT) data, and the instability of reinforcement learning (RL) algorithms in post-training. Group Relative […]

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