July 22, 2025 – Kavli Institute Pre-Print Publications

mGluR4-Npdc1 complex mediates α-synuclein fibril-induced neurodegeneration

Posted by klaurent July 22, 2025August 4, 2025Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Azucena Perez-Canamas, Mingming Chen, Leire Almandoz-Gil, Nabab Khan, Si Jie Tang, Allyson Ho, Erik C Gunther and Stephen M. Strittmatter | Summary: Fibrils of misfolded α-synuclein (α-syn) accumulate in Parkinson’s disease and other synucleinopathies, spreading between cells to template further misfolding and drive neurodegeneration. α-syn fibril entry into healthy […]

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StreamME: Simplify 3D Gaussian Avatar within Live Stream

Posted by klaurent July 22, 2025August 4, 2025UCAS

Kavli Affiliate: Yi Zhou | First 5 Authors: Luchuan Song, Luchuan Song, , , | Summary: We propose StreamME, a method focuses on fast 3D avatar reconstruction. The StreamME synchronously records and reconstructs a head avatar from live video streams without any pre-cached data, enabling seamless integration of the reconstructed appearance into downstream applications. This […]

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On-chip stencil lithography for superconducting qubits

Posted by klaurent July 22, 2025Delft

Kavli Affiliate: Gary A. Steele | First 5 Authors: Roudy Hanna, Roudy Hanna, , , | Summary: Improvements in circuit design and more recently in materials and surface cleaning have contributed to a rapid development of coherent superconducting qubits. However, organic resists commonly used for shadow evaporation of Josephson junctions (JJs) pose limitations due to […]

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On-chip stencil lithography for superconducting qubits

Posted by klaurent July 22, 2025August 4, 2025Delft

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Blood-tumor barrier organoids recapitulate glioblastoma microenvironment and enable high-throughput modeling of therapeutic delivery

Posted by dbos July 22, 2025August 4, 2025Columbia

Kavli Affiliate: Wei Min | Authors: Pei Zhuang, Benjamin Scott, Shuai Gao, Wei-Min Meng, Rui Yin, Xinyu Nie, Ludovica Gaiaschi, Sean E Lawler, Martine LM Lamfers, Fengfeng Bei and Choi-Fong Cho | Summary: The blood-brain barrier (BBB) is a highly specialized system that is critical for regulating transport between the blood and the central nervous […]

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Diet Processing and Nutrient Composition Drive Divergent Obesity Phenotypes in Wistar Rats

Posted by dbos July 22, 2025August 4, 2025UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Pedro Rocha Tenorio, Gabriel Smolak Sobieski e Silva, Débora Hipólito Quadreli, Glaura Scantamburlo Alves Fernandes and Fábio Goulart de Andrade | Summary: Purpose This study aimed to investigate whether food processing, alone or combined with high-fat/high-sugar content, promotes obesity, metabolic syndrome (MtS), and oxidative stress in adult rats. Methods […]

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Mouse pups lacking a cerebral cortex develop abnormal vocal behavior

Posted by dbos July 22, 2025August 4, 2025Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: J. Lomax Boyd, Cesar Vargas and Erich D. Jarvis | Summary: Vocal learning is an essential component of spoken language and critically depends on the cerebral cortex. The evolutionary origins of cortical/pallial control over vocal learning abilities in mammals and songbirds remains largely unknown. For instance, reports conflict on […]

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Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

Posted by dbos July 22, 2025August 4, 2025UCSF

Kavli Affiliate: Tejal Desai | Authors: Qinghe Zeng, Landon Flemming, Yuanzhou Chen, Thomas Mazumder, Heinz Hammerlindl, Greg M. Allen, Ricardo Almeida, Jasper Z. Williams, Rogelio A. Hernandez-Lopez, Justin Eyquem, Chun Jimmie Ye, Wendell A Lim, Qizhi Tang, Tejal Desai and Xiao Huang | Summary: T cell proliferative capacity and persistence critically determine the therapeutic success […]

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Variable X-ray reverberation in the rapidly accreting AGN Ark 564: the response of the soft excess to the changing geometry of the inner accretion flow

Posted by klaurent July 22, 2025August 4, 2025Stanford

Kavli Affiliate: Steven W. Allen | First 5 Authors: Zhefu Yu, Zhefu Yu, , , | Summary: X-ray reverberation, which exploits the time delays between variability in different energy bands as a function of Fourier frequency, probes the structure of the inner accretion disks and X-ray coronae of active galactic nuclei. We present a systematic […]

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Stellar Mass-Dispersion Measure Correlations Constrain Baryonic Feedback in Fast Radio Burst Host Galaxies

Posted by klaurent July 22, 2025August 4, 2025MIT

Kavli Affiliate: Kiyoshi W. Masui | First 5 Authors: Calvin Leung, Calvin Leung, , , | Summary: Low redshift fast radio bursts (FRBs) provide robust measurements of the host-galaxy contribution to the dispersion measure (DM), which can constrain the circumgalactic medium (CGM) of the hosts. We curate a sample of 20 nearby FRBs with low […]

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