July 22, 2025 – Kavli Institute Pre-Print Publications

mGluR4-Npdc1 complex mediates α-synuclein fibril-induced neurodegeneration

Posted by klaurent July 22, 2025August 4, 2025Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Azucena Perez-Canamas, Mingming Chen, Leire Almandoz-Gil, Nabab Khan, Si Jie Tang, Allyson Ho, Erik C Gunther and Stephen M. Strittmatter | Summary: Fibrils of misfolded α-synuclein (α-syn) accumulate in Parkinson’s disease and other synucleinopathies, spreading between cells to template further misfolding and drive neurodegeneration. α-syn fibril entry into healthy […]

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StreamME: Simplify 3D Gaussian Avatar within Live Stream

Posted by klaurent July 22, 2025August 4, 2025UCAS

Kavli Affiliate: Yi Zhou | First 5 Authors: Luchuan Song, Luchuan Song, , , | Summary: We propose StreamME, a method focuses on fast 3D avatar reconstruction. The StreamME synchronously records and reconstructs a head avatar from live video streams without any pre-cached data, enabling seamless integration of the reconstructed appearance into downstream applications. This […]

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On-chip stencil lithography for superconducting qubits

Posted by klaurent July 22, 2025August 4, 2025Delft

Kavli Affiliate: Gary A. Steele | First 5 Authors: Roudy Hanna, Roudy Hanna, , , | Summary: Improvements in circuit design and more recently in materials and surface cleaning have contributed to a rapid development of coherent superconducting qubits. However, organic resists commonly used for shadow evaporation of Josephson junctions (JJs) pose limitations due to […]

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Blood-tumor barrier organoids recapitulate glioblastoma microenvironment and enable high-throughput modeling of therapeutic delivery

Posted by dbos July 22, 2025August 4, 2025Columbia

Kavli Affiliate: Wei Min | Authors: Pei Zhuang, Benjamin Scott, Shuai Gao, Wei-Min Meng, Rui Yin, Xinyu Nie, Ludovica Gaiaschi, Sean E Lawler, Martine LM Lamfers, Fengfeng Bei and Choi-Fong Cho | Summary: The blood-brain barrier (BBB) is a highly specialized system that is critical for regulating transport between the blood and the central nervous […]

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Diet Processing and Nutrient Composition Drive Divergent Obesity Phenotypes in Wistar Rats

Posted by dbos July 22, 2025August 4, 2025UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Pedro Rocha Tenorio, Gabriel Smolak Sobieski e Silva, Débora Hipólito Quadreli, Glaura Scantamburlo Alves Fernandes and Fábio Goulart de Andrade | Summary: Purpose This study aimed to investigate whether food processing, alone or combined with high-fat/high-sugar content, promotes obesity, metabolic syndrome (MtS), and oxidative stress in adult rats. Methods […]

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Mouse pups lacking a cerebral cortex develop abnormal vocal behavior

Posted by dbos July 22, 2025August 4, 2025Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: J. Lomax Boyd, Cesar Vargas and Erich D. Jarvis | Summary: Vocal learning is an essential component of spoken language and critically depends on the cerebral cortex. The evolutionary origins of cortical/pallial control over vocal learning abilities in mammals and songbirds remains largely unknown. For instance, reports conflict on […]

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Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

Posted by dbos July 22, 2025August 4, 2025UCSF

Kavli Affiliate: Tejal Desai | Authors: Qinghe Zeng, Landon Flemming, Yuanzhou Chen, Thomas Mazumder, Heinz Hammerlindl, Greg M. Allen, Ricardo Almeida, Jasper Z. Williams, Rogelio A. Hernandez-Lopez, Justin Eyquem, Chun Jimmie Ye, Wendell A Lim, Qizhi Tang, Tejal Desai and Xiao Huang | Summary: T cell proliferative capacity and persistence critically determine the therapeutic success […]

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Variable X-ray reverberation in the rapidly accreting AGN Ark 564: the response of the soft excess to the changing geometry of the inner accretion flow

Posted by klaurent July 22, 2025August 4, 2025Stanford

Kavli Affiliate: Steven W. Allen | First 5 Authors: Zhefu Yu, Zhefu Yu, , , | Summary: X-ray reverberation, which exploits the time delays between variability in different energy bands as a function of Fourier frequency, probes the structure of the inner accretion disks and X-ray coronae of active galactic nuclei. We present a systematic […]

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Stellar Mass-Dispersion Measure Correlations Constrain Baryonic Feedback in Fast Radio Burst Host Galaxies

Posted by klaurent July 22, 2025August 4, 2025MIT

Kavli Affiliate: Kiyoshi W. Masui | First 5 Authors: Calvin Leung, Calvin Leung, , , | Summary: Low redshift fast radio bursts (FRBs) provide robust measurements of the host-galaxy contribution to the dispersion measure (DM), which can constrain the circumgalactic medium (CGM) of the hosts. We curate a sample of 20 nearby FRBs with low […]

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WGRAMMAR: Leverage Prior Knowledge to Accelerate Structured Decoding

Posted by klaurent July 22, 2025August 4, 2025Peking

Kavli Affiliate: Ran Wang | First 5 Authors: Ran Wang, Ran Wang, , , | Summary: Structured decoding enables large language models (LLMs) to generate outputs in formats required by downstream systems, such as HTML or JSON. However, existing methods suffer from efficiency bottlenecks due to grammar compilation, state tracking, and mask creation. We observe […]

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