JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux

Posted by dbos Yale

Kavli Affiliate: Shawn Ferguson | Authors: Layla M Nassar, xiaojian Shi, Agnes Roczniak-Ferguson, Hongying Shen and Shawn M Ferguson | Summary: Lysosomes break down macromolecules, clear cellular waste and recycle nutrients such as cystine. We describe a novel mechanism whereby JIP4 regulates lysosomal cystine storage by controlling the abundance of cystinosin (CTNS), the transporter responsible […]


Continue.. JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux

Measurement of the CP asymmetry in $D^+ to π^+ π^0$ decays at Belle II

Posted by dbos Tokyo

Kavli Affiliate: T. Higuchi | First 5 Authors: Belle II Collaboration, I. Adachi, L. Aggarwal, H. Ahmed, H. Aihara | Summary: We measure the CP asymmetry in $D^+ to pi^+ pi^0$ decays reconstructed in $e^+ e^-$ collisions at the Belle II experiment using a data set corresponding to an integrated luminosity of 428 fb$^{-1}$. A […]


Continue.. Measurement of the CP asymmetry in $D^+ to π^+ π^0$ decays at Belle II

Mitigating Polarization Leakage in Gas Pixel Detectors through Hybrid Machine Learning and Analytic Event Reconstruction

Posted by dbos Stanford

Kavli Affiliate: Nicola Omodei | First 5 Authors: Nicoló Cibrario, Michela Negro, Raffaella Bonino, Nikita Moriakov, Luca Baldini | Summary: Spatially resolved polarization measurements of extended X-ray sources are expanding our understanding of the emission mechanisms and magnetic field properties involved. Such measurements have been possible in the past few years thanks to the Imaging […]


Continue.. Mitigating Polarization Leakage in Gas Pixel Detectors through Hybrid Machine Learning and Analytic Event Reconstruction

Torsion Balance Experiments Enable Direct Detection of Sub-eV Dark Matter

Posted by dbos Tokyo

Kavli Affiliate: Shigeki Matsumoto | First 5 Authors: Shigeki Matsumoto, Jie Sheng, Chuan-Yang Xing, Lin Zhu, | Summary: Light dark matter with sub-eV masses has a high number density in our galaxy, and its scattering cross section with macroscopic objects can be significantly enhanced by coherence effects. Repeated scattering with a target object can induce […]


Continue.. Torsion Balance Experiments Enable Direct Detection of Sub-eV Dark Matter

Indirect Detection of Dark Matter Around a Supermassive Black Hole with High Energy-Resolution Gamma-Ray Telescopes

Posted by dbos Tokyo

Kavli Affiliate: Shigeki Matsumoto | First 5 Authors: Yu Watanabe, Alexander Kusenko, Shigeki Matsumoto, , | Summary: We explore whether the unprecedented energy resolution of upcoming gamma-ray telescopes can uncover relativistic effects in photon spectra resulting from dark matter (DM) annihilation or decay near the supermassive black hole (SMBH) at the Galactic Center (GC), specifically, […]


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Parametric Gaussian Human Model: Generalizable Prior for Efficient and Realistic Human Avatar Modeling

Posted by dbos UCAS

Kavli Affiliate: Cheng Peng | First 5 Authors: Cheng Peng, Jingxiang Sun, Yushuo Chen, Zhaoqi Su, Zhuo Su | Summary: Photorealistic and animatable human avatars are a key enabler for virtual/augmented reality, telepresence, and digital entertainment. While recent advances in 3D Gaussian Splatting (3DGS) have greatly improved rendering quality and efficiency, existing methods still face […]


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Cryogenic systems for the TUCAN EDM experiment

Posted by dbos Tokyo

Kavli Affiliate: T. Higuchi | First 5 Authors: Jeffery W. Martin, B. Algohi, D. Anthony, L. Barrón-Palos, M. Bradley | Summary: The TUCAN (TRIUMF UltraCold Advanced Neutron) Collaboration is completing a new ultracold neutron (UCN) source. The UCN source will deliver UCNs to a neutron electric dipole moment (EDM) experiment. The EDM experiment is projected […]


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Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity

Posted by dbos Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: Karina Chaudhari, Luis E Guzman-Clavel and Alex L Kolodkin | Summary: There is great diversity in retinal ganglion cells subtypes in the mouse retina, but little is known about the molecular factors required to generate this subtype diversity. Here, we identify the transcription factor Gfi1 as a conserved driver […]


Continue.. Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity

An improved model for prediction of de novo designed proteins with diverse geometries

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Benjamin Orr, Stephanie E Crilly, Deniz Akpinaroglu, Eleanor Zhu, Michael J. Keiser and Tanja Kortemme | Summary: Nature uses structural variations on protein folds to fine-tune the geometries of proteins for diverse functions, yet deep learning-based de novo protein design methods generate highly regular, idealized protein fold geometries that […]


Continue.. An improved model for prediction of de novo designed proteins with diverse geometries