Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity

Posted by dbos UCSF

Kavli Affiliate: Kevin Bender | Authors: Ryan Alexander and Kevin Bender | Summary: Opioids regulate circuits associated with motivation and reward across the brain. Of the opioid receptor types, delta opioid receptors (DORs) appear to have a unique role in regulating the activity of circuits related to reward without a liability for abuse. In neocortex, […]


Continue.. Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity

Proof of principle X-ray reflection mass measurement of the black hole in H1743-322

Posted by dbos MIT

Kavli Affiliate: Erin Kara | First 5 Authors: Edward Nathan, Adam Ingram, James F. Steiner, Ole König, Thomas Dauser | Summary: The black hole X-ray binary H1743-322 lies in a region of the Galaxy with high extinction, and therefore it has not been possible to make a dynamical mass measurement. In this paper we make […]


Continue.. Proof of principle X-ray reflection mass measurement of the black hole in H1743-322

Absence of High-mass Prestellar Cores in the Orion Giant Molecular Cloud

Posted by dbos Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Wenyu Jiao, Ke Wang, Fengwei Xu, , | Summary: A fundamental difference between "core-fed" and "clump-fed" star formation theories lies in the existence or absence of high-mass cores at the prestellar stage. However, only a handful of such cores have been observed. Here, different than previous search […]


Continue.. Absence of High-mass Prestellar Cores in the Orion Giant Molecular Cloud

Correlators of $mathcal{N}=4$ SYM on real projective space at strong coupling

Posted by dbos UCAS

Kavli Affiliate: Xinan Zhou | First 5 Authors: Xinan Zhou, , , , | Summary: We consider type IIB supergravity on a $mathbb{Z}_2$ quotient of AdS$_5times$S$^5$ as the holographic dual of strongly coupled 4d $mathcal{N}=4$ SYM on $mathbb{RP}^4$ space with the gauging of charge conjugation. Using bootstrap techniques, we determine all two-point functions of $frac{1}{2}$-BPS […]


Continue.. Correlators of $mathcal{N}=4$ SYM on real projective space at strong coupling

The SDSS-V Black Hole Mapper Reverberation Mapping Project: Multi-Line Dynamical Modeling of a Highly Variable Active Galactic Nucleus with Decade-long Light Curves

Posted by dbos Peking

Kavli Affiliate: Claudio Ricci | First 5 Authors: Zachary Stone, Yue Shen, Scott F. Anderson, Franz Bauer, W. N. Brandt | Summary: We present dynamical modeling of the broad-line region (BLR) for the highly variable AGN SDSS J141041.25+531849.0 ($z = 0.359$) using photometric and spectroscopic monitoring data from the Sloan Digital Sky Survey Reverberation Mapping […]


Continue.. The SDSS-V Black Hole Mapper Reverberation Mapping Project: Multi-Line Dynamical Modeling of a Highly Variable Active Galactic Nucleus with Decade-long Light Curves

The SDSS-V Black Hole Mapper Reverberation Mapping Project: Multi-Line Dynamical Modeling of a Highly Variable Active Galactic Nucleus with Decade-long Light Curves

Posted by dbos Peking

Kavli Affiliate: Claudio Ricci | First 5 Authors: Zachary Stone, Yue Shen, Scott F. Anderson, Franz Bauer, W. N. Brandt | Summary: We present dynamical modeling of the broad-line region (BLR) for the highly variable AGN SDSS J141041.25+531849.0 ($z = 0.359$) using photometric and spectroscopic monitoring data from the Sloan Digital Sky Survey Reverberation Mapping […]


Continue.. The SDSS-V Black Hole Mapper Reverberation Mapping Project: Multi-Line Dynamical Modeling of a Highly Variable Active Galactic Nucleus with Decade-long Light Curves

ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Eric KF Donahue, Nathaniel L Hepowit, Brennen Keuchel, Alexandra G Mulligan, Derek J Johnson, Mark Ellisman, Rafael Arrojo e Drigo, Jason A MacGurn and Kristopher Burkewitz | Summary: The endoplasmic reticulum (ER) comprises an array of structurally distinct subdomains, each with characteristic functions. While altered ER-associated processes are linked […]


Continue.. ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan

Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility

Posted by dbos UCSF

Kavli Affiliate: Xin Duan | Authors: Julieta Gomez-Frittelli, Gabrielle Frederique Devienne, Lee Travis, Melinda A Kyloh, Xin Duan, Tim J Hibberd, Nick J Spencer, John R Huguenard and Julia Kaltschmidt | Summary: Intrinsic sensory neurons are an essential part of the enteric nervous system (ENS) and play a crucial role in gastrointestinal tract motility and […]


Continue.. Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology

Posted by dbos Hopkins

Kavli Affiliate: Jin Kang | Authors: Yingying Zhang, Alden K Leung, Jin Joo Kang, Yu Sun, Guanxi Wu, Le Li, Jiayang Sun, Lily Cheng, Tian Qiu, Junke Zhang, Shayne Wierbowski, Shagun Gupta, James Booth and Haiyuan Yu | Summary: A major goal of cancer biology is to understand the mechanisms underlying tumorigenesis driven by somatically […]


Continue.. A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology

Dynamical scaling behavior of the two-dimensional random singlet state in the random $Q$ model

Posted by dbos UCAS

Kavli Affiliate: Long Zhang | First 5 Authors: Chen Peng, Long Zhang, , , | Summary: In this work, we study the scaling relation of energy and length scales in the 2D random-singlet (RS) state of the random $Q$ model. To investigate the intrinsic energy scale of the spinon subsystem arising from the model, we […]


Continue.. Dynamical scaling behavior of the two-dimensional random singlet state in the random $Q$ model