Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

Kavli Affiliate: Yifan Cheng | Authors: Xi Liu, Yang Li, Lennice Castro, Zanlin Yu, Yifan Cheng, Matthew D Daugherty and John D Gross | Summary: ZYG11B is a substrate specificity factor for Cullin-RING ubiquitin ligase (CRL2) involved in many biological processes, including Gly/N-degron pathways. Yet how the binding of ZYG11B with CRL2 is coupled to […]


Continue.. Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

Nonlinear compliance of NompC gating spring and its implication in mechanotransduction

Kavli Affiliate: Yuh Nung and Jan Yifan Cheng and Yuh Nung Jan | Authors: Yukun Wang, Peng Jin, Avinash Kumar, Lily Jan, Yifan Cheng, Yuh-Nung Jan and Yongli Zhang | Summary: TCytoskeleton-tethered mechanosensitive channels (MSCs) utilize compliant proteins or protein domains called gating springs to convert mechanical stimuli into electric signals, enabling sound and touch […]


Continue.. Nonlinear compliance of NompC gating spring and its implication in mechanotransduction

Oxytocin receptor function regulates neural signatures of pair bonding and fidelity in the nucleus accumbens

Kavli Affiliate: Devanand Manoli | Authors: Kimberly Lorraine Page Long, Nerissa Emmy Graetz Hoglen, Alex J. Keip, Robert M. Klinkel, Déjenaé L. See, Joseph Maa, Jenna C. Wong, Michael Sherman and Devanand Manoli | Summary: The formation of enduring relationships dramatically influences future behavior, promoting affiliation between familiar individuals. How such attachments are encoded to […]


Continue.. Oxytocin receptor function regulates neural signatures of pair bonding and fidelity in the nucleus accumbens

Nonparametric analysis of correlations in the binary black hole population with LIGO-Virgo-KAGRA data

Kavli Affiliate: Salvatore Vitale | Summary:Formation channels of merging compact binaries imprint themselves on the distributions and correlations of their source parameters, but current understanding of this population is hindered by simplified parametric models. We overcome such limitations using PixelPop [Heinzel et al. (2025)]-our Bayesian nonparametric multidimensional population model. We analyze data from the first […]


Continue.. Nonparametric analysis of correlations in the binary black hole population with LIGO-Virgo-KAGRA data

PixelPop: High Resolution Nonparameteric Inference of Gravitational-Wave Populations in Multiple Dimensions

Kavli Affiliate: Salvatore Vitale | Summary:The origins of merging compact binaries observed by gravitational-wave detectors remains highly uncertain. Several astrophysical channels may contribute to the overall merger rate, with distinct formation processes imprinted on the structure and correlations in the underlying distributions of binary source parameters. In the absence of confident theoretical models, the current […]


Continue.. PixelPop: High Resolution Nonparameteric Inference of Gravitational-Wave Populations in Multiple Dimensions

MEReQ: Max-Ent Residual-Q Inverse RL for Sample-Efficient Alignment from Intervention

Kavli Affiliate: Xiang Zhang | First 5 Authors: Yuxin Chen, Yuxin Chen, , , | Summary: Aligning robot behavior with human preferences is crucial for deploying embodied AI agents in human-centered environments. A promising solution is interactive imitation learning from human intervention, where a human expert observes the policy’s execution and provides interventions as feedback. […]


Continue.. MEReQ: Max-Ent Residual-Q Inverse RL for Sample-Efficient Alignment from Intervention

Probing critical spin fluctuations with a composite magnetoelectric method: A case study on a Kitaev spin liquid candidate Na$_3$Co$_2$SbO$_6$

Kavli Affiliate: Long Zhang | First 5 Authors: Xinrun Mi, Xintong Li, Long Zhang, Aifeng Wang, Yuan Li | Summary: In correlated quantum materials, divergent critical fluctuations near the quantum critical point are often closely associated with exotic quantum phases of matter, such as unconventional superconductivity and quantum spin liquids. Here we present a simple […]


Continue.. Probing critical spin fluctuations with a composite magnetoelectric method: A case study on a Kitaev spin liquid candidate Na$_3$Co$_2$SbO$_6$

Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline

Kavli Affiliate: Flora Vaccarino | Authors: Yeongjun Jang, Livia Tomasini, Taejeong Bae, Anna Szekely, Flora M. Vaccarino and Alexej Abyzov | Summary: Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing […]


Continue.. Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline

The FRB-searching pipeline of the Tianlai Cylinder Pathfinder Array

Kavli Affiliate: Albert Stebbins | First 5 Authors: Zijie Yu, Furen Deng, Shijie Sun, Chenhui Niu, Jixia Li | Summary: This paper presents the design, calibration, and survey strategy of the Fast Radio Burst (FRB) digital backend and its real-time data processing pipeline employed in the Tianlai Cylinder Pathfinder array. The array, consisting of three […]


Continue.. The FRB-searching pipeline of the Tianlai Cylinder Pathfinder Array

Tailored topotactic chemistry unlocks heterostructures of magnetic intercalation compounds

Kavli Affiliate: Kwabena Bediako| Summary:The construction of thin film heterostructures has been a widely successful archetype for fabricating materials with emergent physical properties. This strategy is of particular importance for the design of multilayer magnetic architectures in which direct interfacial spin–spin interactions between magnetic phases in dissimilar layers lead to emergent and controllable magnetic behavior. […]


Continue.. Tailored topotactic chemistry unlocks heterostructures of magnetic intercalation compounds