Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Posted by dbos Columbia

Kavli Affiliate: Franck Polleux | Authors: Carlos Diaz-Salazar, Marine A KRZISCH, Juyoun Yoo, Patricia Nano, Aparna Bhaduri, Rudolph Jaenisch and Franck Polleux | Summary: Microglia play key roles in shaping synaptic connectivity during neural circuits development. Whether microglia display human-specific features of structural and functional maturation is currently unknown. We show that the ancestral gene […]


Continue.. Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Gannon A. McDonough, Yuchen Cheng, Katherine Morillo, Ryan N. Doan, Connor J. Kenny, Aaron Foutz, Chae Kim, Mark L. Cohen, Brian S. Appleby, Christopher A. Walsh, Jiri G. Safar, August Yue Huang and Michael B. Miller | Summary: Creutzfeldt-Jakob Disease (CJD), the most common human prion disease, is associated […]


Continue.. Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans

Posted by dbos UCSF

Kavli Affiliate: Saul Kato | Authors: Daniel Yutaka Sprague, Kevin Rusch, Raymond L Dunn, Jackson Borchardt, Greg Bubnis, Grace Chiu, Chentao Wen, Ryoga Suzuki, Shivesh Chaudhary, Ben Dichter, Ryan Ly, Shuichi Onami, Hang Lu, Kotaro Kimura, Eviatar I Yemini and Saul Kato | Summary: We develop a data harmonization approach for C. elegans volumetric microscopy […]


Continue.. Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans

YuLan: An Open-source Large Language Model

Posted by dbos Berkeley

Kavli Affiliate: Feng Wang | First 5 Authors: Yutao Zhu, Kun Zhou, Kelong Mao, Wentong Chen, Yiding Sun | Summary: Large language models (LLMs) have become the foundation of many applications, leveraging their extensive capabilities in processing and understanding natural language. While many open-source LLMs have been released with technical reports, the lack of training […]


Continue.. YuLan: An Open-source Large Language Model

YuLan: An Open-source Large Language Model

Posted by dbos Berkeley

Kavli Affiliate: Feng Wang | First 5 Authors: Yutao Zhu, Kun Zhou, Kelong Mao, Wentong Chen, Yiding Sun | Summary: Large language models (LLMs) have become the foundation of many applications, leveraging their extensive capabilities in processing and understanding natural language. While many open-source LLMs have been released with technical reports, the lack of training […]


Continue.. YuLan: An Open-source Large Language Model

Rateless Stochastic Coding for Delay-Constrained Semantic Communication

Posted by dbos UCAS

Kavli Affiliate: Cheng Peng | First 5 Authors: Cheng Peng, Rulong Wang, Yong Xiao, , | Summary: We consider the problem of joint source-channel coding for semantic communication from a rateless perspective, the purpose of which is to settle the balance between reliability (distortion/perception) and effectiveness (rate) of transmission over uncertain channels. In particular, we […]


Continue.. Rateless Stochastic Coding for Delay-Constrained Semantic Communication

Rateless Stochastic Coding for Delay-Constrained Semantic Communication

Posted by dbos UCAS

Kavli Affiliate: Cheng Peng | First 5 Authors: Cheng Peng, Rulong Wang, Yong Xiao, , | Summary: We consider the problem of joint source-channel coding for semantic communication from a rateless perspective, the purpose of which is to settle the balance between reliability (distortion/perception) and effectiveness (rate) of transmission over uncertain channels. In particular, we […]


Continue.. Rateless Stochastic Coding for Delay-Constrained Semantic Communication

Rateless Stochastic Coding for Delay-constrained Semantic Communication

Posted by dbos UCAS

Kavli Affiliate: Cheng Peng | First 5 Authors: Cheng Peng, Rulong Wang, Yong Xiao, , | Summary: We consider the problem of joint source-channel coding with distortion and perception constraints from a rateless perspective, the purpose of which is to settle the balance between reliability (distortion/perception) and effectiveness (rate) of transmission over uncertain channels. We […]


Continue.. Rateless Stochastic Coding for Delay-constrained Semantic Communication

Epistasis between N-terminal and receptor-binding domains drives cell entry in a bat coronavirus spike

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Alexandra L. Tse, Cory M. Acreman, Inna Ricardo-Lax, Jacob Berrigan, Gorka Lasso, Toheeb Balogun, Fiona L. Kearns, Lorenzo Casalino, Georgia L. McClain, Amartya Mudry Chandran, Charlotte Lemeunier, Rommie E. Amaro, Charles M. Rice, Rohit K. Jangra, Jason S. McLellan, Kartik Chandran and Emily Happy Miller | Summary: The […]


Continue.. Epistasis between N-terminal and receptor-binding domains drives cell entry in a bat coronavirus spike

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

Posted by dbos UCSF

Kavli Affiliate: Daniel Minor | Authors: Shatabdi Roy-Chowdhury, Seil Jang, Fayal Abderemane-Ali, Fiona Naughton, Michael Grabe and Daniel L Minor, Jr. | Summary: The halothane-inhibited K2P leak potassium channel K2P13.1 (THIK-1)1–3 is found in diverse cells1,4 including neurons1,5 and microglia6–8 where it affects surveillance6, synaptic pruning7, phagocytosis7, and inflammasome-mediated interleukin-1β release6,8,9. As with many K2Ps1,5,10–14 […]


Continue.. Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site