Scalable high-fidelity human vascularized cortical assembloids recapitulate neurovascular co-development and cell specialization

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Arnold R. Kriegstein and Edward Chang | Authors: Shubhang Bhalla, Belda Gulsuyu, Damian Sanchez, Jayden M Ross, Santhosh Arul, Adnan Gopinadhan, Muhammet Ozturk, Tanzila Mukhtar, Jonathan J Augustin, Jerry C Wang, Joseph Kim, Chang N Kim, Sena Oten, Yohei Rosen, […]


Continue.. Scalable high-fidelity human vascularized cortical assembloids recapitulate neurovascular co-development and cell specialization

A genetically encoded reporter reveals interferon responses in multiple cell lineages

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Anna Molofsky | Authors: Sarah R Anderson, Pailin Chiaranunt, Nicholas M Mroz, Sarah D Wade, Ari B Molofsky and Anna V Molofsky | Summary: Interferons (IFNs) are canonical antiviral cytokines with emerging homeostatic functions across tissues, including in the brain. […]


Continue.. A genetically encoded reporter reveals interferon responses in multiple cell lineages

An orthogonal TRAP enables intersectional genetic access to activated neurons in the mouse brain

Kavli Affiliate: Zachary Knight | Authors: Nikolaos Chatziris, Brooke C Jarvie, Can Liu and Zachary A Knight | Summary: The study of neural circuits has been greatly enabled by methods for obtaining genetic access to activated neurons. However, these approaches typically tag neurons based on their response to only a single stimulus, which limits the […]


Continue.. An orthogonal TRAP enables intersectional genetic access to activated neurons in the mouse brain

Progenitor Diversity and Architecture of the Human Ganglionic Eminences Shaping the Basal Ganglia

Kavli Affiliate: John Rubenstein, Arnold R. Kriegstein, and Arturo Alvarez-Buylla | Authors: Clara V. Siebert, Mengyi Song, Juan A. Moriano, Zhengmeiyu Li, Arantxa Cebrian Silla, Miranda Walker, Songcang Chen, Jennifer Baltazar, Lilian Gomes de Oliveira, Merut Shankar, Yuhan Xie, Pranav Suraparaju, Shaohui Wang, Qiuli Bi, Yajun Xie, Yuqi Ren, Miguel Turrero Garcia, Li Wang, Guolong […]


Continue.. Progenitor Diversity and Architecture of the Human Ganglionic Eminences Shaping the Basal Ganglia

Meta-learning is expressed through altered prefrontal cortical dynamics

Kavli Affiliate: Joshua Berke, Loren Frank, and Razi Haque | Authors: Xulu Sun, Alison E. Comrie, Ari E. Kahn, Emily J. Monroe, Abhilasha Joshi, Jennifer A. Guidera, Eric L. Denovellis, Timothy A. Krausz, Jenny Zhou, Paige Thompson, Jose Hernandez, Allison Yorita, Razi Haque, Joshua D. Berke, Nathaniel D. Daw and Loren M. Frankn | Summary: […]


Continue.. Meta-learning is expressed through altered prefrontal cortical dynamics

High-Fidelity Neural Speech Reconstruction through an Efficient Acoustic-Linguistic Dual-Pathway Framework

Kavli Affiliate: Edward Chang | Authors: Jiawei Li, Chunxu Guo, Chao Zhang, Edward F Chang and Yuanning Li | Summary: Reconstructing speech from neural recordings is crucial for understanding speech coding and developing brain-computer interfaces (BCIs). However, existing methods trade off acoustic richness (pitch, prosody) for linguistic intelligibility (words, phonemes). To overcome this limitation, we […]


Continue.. High-Fidelity Neural Speech Reconstruction through an Efficient Acoustic-Linguistic Dual-Pathway Framework

Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer’s disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types

Kavli Affiliate: Robert Edwards | Authors: Susana Furman, Latifa Zayou, Kate I Inman Tsourmas, Dominic Ibarra Javonillo, Gema M Olivarria, Yuting Cheng, Collin Pachow, Kellie Fernandez, Lucas Le, Robert Andrew Edwards, Dequina Nicholas, Gabriela Pacheco Sanchez, Ralph S. Baric, Kim N Green and Thomas E. Lane | Summary: Alzheimer’s disease (AD) is a progressive neurodegenerative […]


Continue.. Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer’s disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types

Central carbon metabolism switching in lytic versus temperate coral reef viral communities

Kavli Affiliate: Robert Edwards | Authors: Jacob Kelman, Meena Khan, Chibundu Umunna, Russell Brainard, Grace Donohue, Robert A Edwards, Natalie A Falta, Emma E. George, Eleanor Gorham, Juris Grasis, Kevin Green, Andreas F Haas, Kimberly Halsey, Eric Hester, Summer Jacob, Aydin Loid Karatas, Yan Wei Lim, Mark Little, Stuart Sandin, Jessie Segnitz, Maya Serota, Natalia […]


Continue.. Central carbon metabolism switching in lytic versus temperate coral reef viral communities

Degraded sensory coding in a mouse model of Scn2a-related disorder and its rescue by CRISPRa gene activation

Kavli Affiliate: Kevin Bender | Authors: Kaeli Vandemark, Hannah R Monday, Lucia Rodriguez, Manya Zhao, Meeseo Lee, Amit Ahituv, Anwita Satapathy, Nicolas F Page, Kelly An, Elizabeth C Hamada, Nadav Ahituv, Kevin J Bender and Daniel E Feldman | Summary: Heterozygous loss-of-function mutations in SCN2A, a sodium channel gene expressed in cortical pyramidal (PYR) cells, […]


Continue.. Degraded sensory coding in a mouse model of Scn2a-related disorder and its rescue by CRISPRa gene activation

An integrated workflow for structural virology with a 100 keV electron microscope

Kavli Affiliate: Robert Edwards | Authors: Rasangi Pathirage, Moumita Dutta, Ruth J Parsons, Muralikirshna Lella, Emma Atwood, Qianyi E Zhang, Aaron May, Alexis Johnson, Xiao Huang, Jordan Flemming, Ujjwal Kumar, Bahjat F. Marayati, M. Ariel Spurrier, Coco Liu, Junlin Zhuo, Ki Song, Radha Devkota Adhikari, Salam Sammour, Victor Ilevbare, Carter Abram, Michael Diaz, Albert Guzman, […]


Continue.. An integrated workflow for structural virology with a 100 keV electron microscope