Kavli Affiliate: Hana El-Samad | Authors: Zara Y. Weinberg, Sarah S. Soliman, Matthew S. Kim, Irene P. Chen, Melanie Ott and Hana El-Samad | Summary: Synthetic and chimeric receptors capable of recognizing and responding to user-defined antigens have enabled “smart” therapeutics based on engineered cells. These cell engineering tools depend on antigen sensors which are […]

Kavli Affiliate: Joshua Berke | Authors: James Taniguchi, Riccardo Melani, Lynne Chantranupong, Michelle J Wen, Ali Mohebi, Joshua D Berke, Bernardo L Sabatini and Nicolas X Tritsch | Summary: Acetylcholine is widely believed to modulate the release of dopamine in the striatum of mammals. Experiments in brain slices clearly show that synchronous activation of striatal […]

Kavli Affiliate: Alan David Kaplan | Authors: Duy Duong-Tran, Ralph Kaufmann, Jiong Chen, Xuan Wang, Sumita Garai, Frederick Xu, Jingxuan Bao, Enrico Amico, Alan David Kaplan, Giovanni Petri, Joaquin Goni, Yize Zhao and Li Shen | Summary: Human whole-brain functional connectivity networks have been shown to exhibit both local/quasilocal (e.g., set of functional sub-circuits induced […]

Kavli Affiliate: Michael Stryker | Authors: Antonella Antonini, Sheri L Harris and Michael P Stryker | Summary: Current hypotheses on the mechanisms underlying the development and plasticity of the ocular dominance system through competitive interactions between pathways serving the two eyes strongly suggest the involvement of neurotrophins and their high affinity receptors. In the cat, […]

Kavli Affiliate: Robert Edwards | Authors: Ryan Cook, Andrea Telatin, George Bouras, Antonio Pedro Camargo, Martin Larralde, Robert A Edwards and Evelien M Adriaenssens | Summary: The majority of bacteriophage diversity remains uncharacterised, and new intriguing mechanisms of their biology are being continually described. Members of some phage lineages, such as the Crassvirales, repurpose stop […]

Kavli Affiliate: Philip Starr | Authors: Colin W Hoy, Coralie de Hemptinne, Sarah S Wang, Catherine J Harmer, Matthew A J Apps, Masud Husain, Philip A Starr and Simon Little | Summary: Choosing whether to exert effort to obtain rewards is fundamental to human motivated behavior. However, the neural dynamics underlying the evaluation of reward […]

Kavli Affiliate: Kira Poskanzer | Authors: Michelle K. Cahill, Yeraldith Rojas Perez, Amara Larpthaveesarp, Roberto Etchenique and Kira E Poskanzer | Summary: Norepinephrine (NE) is a critical neuromodulator that mediates a wide range of behavior and neurophysiology, including attention, arousal, plasticity, and memory consolidation. A major source of NE is the brainstem nucleus the locus […]

Kavli Affiliate: Reza Abbasi Asl & Adam Gazzaley | Authors: Fernando E. Rosas, Pedro A.M. Mediano, Christopher Timmermann, Andrea I Luppi, Diego Candia-Rivera, Reza Abbasi-Asl, Adam Gazzaley, Morten L Kringelbach, Suresh Daniel Muthukumaraswamy, Daniel Bor, Sarah Garfinkel and Robin Carhart-Harris | Summary: A growing body of work shows that autonomic signals provide a privileged evidence-stream […]

Kavli Affiliate: Vikaas Sohal | Authors: Nicholas A Frost, Kevin C Donohue and Vikaas Sohal | Summary: The prefrontal cortex plays a key role in social interactions, anxiety-related avoidance, and flexible context- dependent behaviors, raising the question: how do prefrontal neurons represent socioemotional information across different environments? Are contextual and socioemotional representations segregated or intermixed, […]