Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate

Kavli Affiliate: Kira Poskanzer | Authors: Kira Poskanzer, Trisha V Vaidyanathan, Vincent Tse and Esther M Lim | Summary: Astrocytes perform critical functions in the nervous system, many of which are dependent on neurotransmitter-sensing through G protein-coupled receptors (GPCRs). However, whether specific astrocytic outputs follow specific GPCR activity remains unclear, and exploring this question is […]


Continue.. Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

Kavli Affiliate:Allan Basbaum | Authors: Wendy W.S. Yue, Lin Yuan, Joao M. Bráz, Allan I. Basbaum and David Julius | Summary: TRPV1, a capsaicin- and heat-sensitive ion channel, is expressed by peripheral nociceptors and has been implicated in various inflammatory and neuropathic pain conditions. Although pharmacological modulation of TRPV1 has attracted therapeutic interest, their utility […]


Continue.. TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses

Kavli Affiliate: Saul Kato | Authors: Rashmi Chandra, Fatima Farah, Fernando Munoz-Lobato, Anirudh Bokka, Kelli L Benedetti, Chantal Brueggemann, Fatema Mashel Saifuddin, Julia M. Miller, Joy Li, Eric Chang, Aruna Varshney, Vanessa Jiminez, Anjana Baradwaj, Cibelle Nassif, Sara Alladin, Kristine E Andersen, Veronica Bi, Sarah K Nordquist, Raymond L Dunn, Bryan Tsujimoto, Alan Tran, Alexander […]


Continue.. Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses

A Spectrum of Time Horizons for Dopamine Signals

Kavli Affiliate: Joshua Berke | Authors: Wei Wei, Ali Mohebi and Joshua Berke | Summary: Dopamine input to striatum can encode reward prediction error, a critical signal for updating predictions of future rewards. However, it is unclear how this mechanism handles the need to make predictions, and provide feedback, over multiple time horizons: from seconds […]


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Deep learning from multiple experts improves identification of amyloid neuropathologies

Kavli Affiliate: Michael Keiser | Authors: Daniel R. Wong, Ziqi Tang, Nicholas C. Mew, Sakshi Das, Justin Athey, Kirsty E. McAleese, Julia K. Kofler, Margaret E. Flanagan, Ewa Borys, Charles L. White III, Atul J Butte, Brittany N Dugger and Michael J. Keiser | Summary: Pathologists can label pathologies differently, making it challenging to yield […]


Continue.. Deep learning from multiple experts improves identification of amyloid neuropathologies

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

Kavli Affiliate: Robert Edwards | Authors: Victoria Stalls, Jared Lindenberger, Sophie Gobeil, Rory Henderson, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Robert J Edwards, Amanda Eaton, David Montefiori, Wilton Williams, Kevin O’Neil Saunders, Kevin Wiehe, Barton F Haynes and Priyamvada Acharya | Summary: The […]


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Long-range inhibition synchronizes and updates prefrontal task activity

Kavli Affiliate: Vikaas Sohal | Authors: Kathleen Cho, Jingcheng Shi and Vikaas Singh Sohal | Summary: Changes in patterns of activity within the medial prefrontal cortex enable rodents, non-human primates, and humans to update their behavior to adapt to changes in the environment, e.g., during cognitive tasks1–5. Within medial prefrontal cortex, inhibitory neurons expressing parvalbumin […]


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CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

Kavli Affiliate: Kevin Bender, Jeanne Tamar Paz | Authors: Serena Tamura, Andrew D Nelson, Perry WE Spratt, Henry Kyoung, Xujia Zhou, Zizheng Li, Jingjing Zhao, Stephanie S Holden, Atehsa Sahagun, Caroline M Keeshen, Congyi Lu, Elizabeth C Hamada, Roy Ben-Shalom, Jen Q Pan, Jeanne T Paz, Stephan J Sanders, Navneet Matharu, Nadav Ahituv and Kevin […]


Continue.. CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

The Neurodata Without Borders ecosystem for neurophysiological data science

Kavli Affiliate: Kristofer Bouchard, Loren Frank | Authors: Oliver Rübel, Andrew Tritt, Ryan Ly, Benjamin K. Dichter, Satrajit Ghosh, Lawrence Niu, Ivan Soltesz, Karel Svoboda, Loren Frank and Kristofer E. Bouchard | Summary: The neurophysiology of cells and tissues are monitored electrophysiologically and optically in diverse experiments and species, ranging from flies to humans. Understanding […]


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Persistent postnatal migration of interneurons into the human entorhinal cortex

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Marcos Assis Nascimento, Sean Biagiotti, Vicente Herranz-Perez, Raymund Bueno, Chun Jimmie Ye, Taylor Abel, Juan S Rubio Moll, Jose Manuel Garcia-Verdugo, Eric J. Huang, Arturo Alvarez-Buylla and Shawn F Sorrells | Summary: The entorhinal cortex (EC) is a highly-interconnected hub for multisensory integration and memory processing1-3, containing diverse neuronal […]


Continue.. Persistent postnatal migration of interneurons into the human entorhinal cortex