Kavli Affiliate: Robert Edwards | Authors: Cedric Lood, Swapnil Doijad, Evelien Adriaenssens, Yiming Bao, Jakub Barylski, Benjamin Bolduc, George Bouras, Rodney J. Brister, Titus C. Brown, Antonio Pedro Camargo, Lander De Coninck, Sebastian Deorowicz, Robert Edgar, Robert Edwards, Shitao Gong, Arthur Gruber, Adam Gudys, Ernestina Hauptfeld, Anneliek ter Horst, Tianyang Huang, Jingzhe Jiang, Lars Kaderali, […]
Kavli Affiliate: Yifan Cheng | Authors: Chengmin Li, Wooyoung Choi, Hao Wu and Yifan Cheng | Summary: In single particle cryo-EM, analysis of continuous conformational heterogeneity has always been challenging. Both linear and deep learning-based methods treat conformational heterogeneity as perturbations to the consensus average conformation, limiting their capability in analyzing large protein motions. While […]
Kavli Affiliate: Robert Edwards | Authors: Anita Tarasenko, Bhavya Papudeshi, Van Nguyen, Susanna Rose Grigson, George Bouras, Vijini Mallawaarachchi, Abbey Louise, Kelly Hutton, Renee Green, Jack Ramsay, Hamza Hajama, Ana Georgina Cobian-Guemes, Anca Mara Segall, Morgyn Warner, Sarah Giles, Clarice Harker and Robert A Edwards | Summary: Achromobacter species are emerging multidrug-resistant (MDR) pathogens in people […]
Kavli Affiliate: Lily Jan | Authors: Kunal Shroff, Molly C O’Brien, Tyler J Smith, Jialing Fang, Kelly S Yu, Sonia I Lombroso, Shengjie Feng, Chao Chen, Gregory A Mohl, Indigo V L Rose, Nidhi R Lokesh, Mark E Pownall, Lily Y Jan and Martin Kampmann | Summary: Neuronal synapses are eliminated during brain development and […]
Kavli Affiliate: Bjoern Schwer | Authors: Joseph A Stewart, Jeanmarie Mishler, Samreen Ahmed, Bjoern Schwer, Thomas W. Glover and Thomas E Wilson | Summary: High-fidelity detection of rare structural variants (SVs) remains challenging because library preparation and sequencing techniques generate artifactual junctions that obscure true single-molecule events. Here, we present HiFiRe3, an error-minimized sequencing framework […]
Kavli Affiliate: Alexandra Nelson | Authors: Emily L Twedell, Chloe J Bair-Marshall, Allison E Girasole, Lara K Scaria, Sadhana Sridhar and Alexandra B Nelson | Summary: Striatal medium spiny neurons (MSNs) integrate convergent cortical, thalamic, and dopaminergic inputs to shape motor output. In addition, MSNs form local inhibitory synaptic connections with one another. The function […]
Kavli Affiliate: Yifan Cheng | Authors: Makoto Nakamura, Xiaoxin Chen, Shun Yao, Lynette Xin Chan, Ruan Hongmei, Alexis Boulinguiez, Nav Lally, Hao Wu, Kara Kodani, Kentaro Hirose, James Pirruccello, Alberto Malerba, Yifan Cheng, Vasanth Vedantham, Longzhi Tan, Jeffrey E. Olgin, Di Lang and Guo N. Huang | Summary: Three-dimensional genome organization stabilizes cell-type-specific gene expression, […]
Kavli Affiliate: Edward Chang | Authors: Jeremy Saal, Ankit N. Khambhati, Edward F. Chang and Prasad Shirvalkar | Summary: Chronic pain engages distributed cortical and subcortical circuits, and large-scale intracranial recordings in humans offer a valuable opportunity to characterize its neural signatures. Here, we recorded multi-day stereoelectroencephalography (sEEG) from six participants with refractory chronic neuropathic […]
Kavli Affiliate: David Rowitch | Authors: Guy LAM, Zhaoyang Xu, Adrien M Vaquie, Stavros Vagionitis, Michael Perry, Omar de Faria, Jr., Georgios Solomou, John H Stockley, Gemma C Girdler, Daniel Yamamoto, Juan A Oses, Qianqian Zhang, Gregory Jordan, Laura R Morcom, Jacob Stillman, Hani S Mousa, Alma Burlingame, Murray Stewart, Hauke B. Werner, Andras Lakatos, […]
Kavli Affiliate: Zachary Knight | Authors: Alejandro Lopez-Cruz, Natalie S. Figueredo Burgos, Anna M Hakimi, Kathryn Xie, Mo Mao, Mahekdeep Kaur, Antionette Spina, Katie Choi, Longhui Qui, Teresa E Lever, Fiona M Gribble, Frank Reimann, Martin G Myers, Alice E Adriaenssens and Zachary A Knight | Summary: Nausea arises from activation of specialized neurons in […]