SARS-CoV-2 Omicron lineage XBB spike structures, conformations, antigenicity, and receptor recognition

Kavli Affiliate: Robert Edwards | Authors: Qianyi E Zhang, Jared Lindenberger, Ruth Parsons, Bhishem Thakur, Rob Parks, Chan Soo Park, Xiao Huang, Salam Sammour, Katarzyna Janowska, Taylor N Spence, Robert J. Edwards, Mitchell Martin, Wilton B Williams, Sophie Gobeil, David C Montefiori, Bette Korber, Kevin O’Neil Saunders, Barton F Haynes, Barton F. Haynes, Rory Henderson […]


Continue.. SARS-CoV-2 Omicron lineage XBB spike structures, conformations, antigenicity, and receptor recognition

Intercalated amygdala dysfunction drives extinction deficits in the Sapap3 mouse model of obsessive-compulsive disorder

Kavli Affiliate: Anatol Kreitzer | Authors: Robyn St. Laurent, Kelly M Kusche, Anatol C Kreitzer and Robert C Malenka | Summary: Background The avoidance of aversive stimuli due to negative reinforcement learning is critical for survival in real-world environments, which demand dynamic responding to both positive and negative stimuli that often conflict with each other. […]


Continue.. Intercalated amygdala dysfunction drives extinction deficits in the Sapap3 mouse model of obsessive-compulsive disorder

Neurofeedback training can modulate task-relevant memory replay in rats

Kavli Affiliate: Loren Frank | Authors: Anna K Gillespie, Daniela A Astudillo Maya, Eric L. Denovellis, Sachi Desse and Loren M Frank | Summary: Hippocampal replay – the time-compressed, sequential reactivation of ensembles of neurons related to past experience – is a key neural mechanism of memory consolidation. Replay typically coincides with a characteristic pattern […]


Continue.. Neurofeedback training can modulate task-relevant memory replay in rats

A foundational atlas of autism protein interactions reveals molecular convergence

Kavli Affiliate: Jeremy Willsey | Authors: Belinda Wang, Rasika Vartak, Yefim Zaltsman, Zun Zar Chi Naing, Kelsey M Hennick, Benjamin J Polacco, Ali Bashir, Manon Eckhardt, Mehdi Bouhaddou, Jiewei Xu, Nawei Sun, Micaela Lasser, Yuan Zhou, Keelan Z Guiley, Una Chan, Julia A Kaye, Prachi Khare, Sam Drake, Vanessa Drury, David F Burke, Silvano Gonzalez, […]


Continue.. A foundational atlas of autism protein interactions reveals molecular convergence

Protein property prediction based on local environment by 3D equivariant convolutional neural networks

Kavli Affiliate: Yifan Cheng | Authors: He Chen, Yifan Cheng, Jianqiang Dong, Jie Mao, Xin Wang, Yuan Gao, Yuchao Li, Chengzhi Wang and Qiong Wu | Summary: Predicting the properties of proteins is an important procedure in protein engineering. It determines the subspace of mutations for protein modifications, which is critical to the success of […]


Continue.. Protein property prediction based on local environment by 3D equivariant convolutional neural networks

An experimental census of retrons for DNA production and genome editing

Kavli Affiliate: Seth Shipman | Authors: Asim G. Khan, Matías Rojas-Montero, Alejandro González-Delgado, Santiago C. Lopez, Rebecca F. Fang and Seth L. Shipman | Summary: Abstract Retrons are bacterial immune systems that use reverse transcribed DNA as a detector of phage infection. They are also increasingly deployed as a component of biotechnology. For genome editing, […]


Continue.. An experimental census of retrons for DNA production and genome editing

Regional specialization manifests in the reliability of neural population codes

Kavli Affiliate: Razi Haque Christoph Kirst Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Sam Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Andrew Tritt, Oliver Oliver Ruebel, Thinh Nguyen, […]


Continue.. Regional specialization manifests in the reliability of neural population codes

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

Kavli Affiliate: Xin Duan, Arnold R. Kriegstein, and Xin Duan | Authors: Li Wang, Cheng Wang, Juan A. Moriano, Songcang Chen, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Arantxa Cebrian-Silla, Qiuli Bi, Jonathan J. Augustin, Lilian G. de Oliveira, Mengyi Song, Xinxin Ge, Guolong Zuo, Mercedes F. Paredes, Eric J. Huang, Arturo Alvarez-Buylla, Xin Duan, Jingjing […]


Continue.. Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

De novo-designed minibinders expand the synthetic biology sensing repertoire

Kavli Affiliate: Hana El-Samad | Authors: Zara Y. Weinberg, Sarah S. Soliman, Matthew S. Kim, Irene P. Chen, Melanie Ott and Hana El-Samad | Summary: Synthetic and chimeric receptors capable of recognizing and responding to user-defined antigens have enabled “smart” therapeutics based on engineered cells. These cell engineering tools depend on antigen sensors which are […]


Continue.. De novo-designed minibinders expand the synthetic biology sensing repertoire

Comment on ‘Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation’

Kavli Affiliate: Joshua Berke | Authors: James Taniguchi, Riccardo Melani, Lynne Chantranupong, Michelle J Wen, Ali Mohebi, Joshua D Berke, Bernardo L Sabatini and Nicolas X Tritsch | Summary: Acetylcholine is widely believed to modulate the release of dopamine in the striatum of mammals. Experiments in brain slices clearly show that synchronous activation of striatal […]


Continue.. Comment on ‘Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation’