Degraded sensory coding in a mouse model of Scn2a-related disorder and its rescue by CRISPRa gene activation

Kavli Affiliate: Kevin Bender | Authors: Kaeli Vandemark, Hannah R Monday, Lucia Rodriguez, Manya Zhao, Meeseo Lee, Amit Ahituv, Anwita Satapathy, Nicolas F Page, Kelly An, Elizabeth C Hamada, Nadav Ahituv, Kevin J Bender and Daniel E Feldman | Summary: Heterozygous loss-of-function mutations in SCN2A, a sodium channel gene expressed in cortical pyramidal (PYR) cells, […]


Continue.. Degraded sensory coding in a mouse model of Scn2a-related disorder and its rescue by CRISPRa gene activation

An integrated workflow for structural virology with a 100 keV electron microscope

Kavli Affiliate: Robert Edwards | Authors: Rasangi Pathirage, Moumita Dutta, Ruth J Parsons, Muralikirshna Lella, Emma Atwood, Qianyi E Zhang, Aaron May, Alexis Johnson, Xiao Huang, Jordan Flemming, Ujjwal Kumar, Bahjat F. Marayati, M. Ariel Spurrier, Coco Liu, Junlin Zhuo, Ki Song, Radha Devkota Adhikari, Salam Sammour, Victor Ilevbare, Carter Abram, Michael Diaz, Albert Guzman, […]


Continue.. An integrated workflow for structural virology with a 100 keV electron microscope

A genetic screen in enteroendocrine cells reveals mechanisms that control protein sensing and GLP-1 release

Kavli Affiliate: Zachary Knight | Authors: Shenliang Yu, Yoochae Lee, Steven C Boggess, Nicole R Klein, Noam Teyssier, Martin Kampmann and Zachary A Knight | Summary: Enteroendocrine cells (EECs) are the principal nutrient sensors in the gastrointestinal (GI) tract and release hormones such as glucagon-like-peptide 1 (GLP-1) that modulate GI function and appetite. While some […]


Continue.. A genetic screen in enteroendocrine cells reveals mechanisms that control protein sensing and GLP-1 release

Towards individualized deep brain stimulation: A stereoelectroencephalography-based workflow for neurostimulation target identification

Kavli Affiliate: Edward Chang | Authors: Jeremy Saal, Kelly Kadlec, Anusha B. Allawala, Lucille Johnston, Ryan Leriche, Ritwik Vatsyayan, Yiyuan Han, Audrey Kist, Tommaso Di Ianni, Heather E. Dawes, Edward F. Chang, A Moses Lee, Andrew D. Krystal, Khaled Moussawi, Prasad Shirvalkar and Kristin K. Sellers | Summary: Objectives Deep brain stimulation (DBS) is increasingly […]


Continue.. Towards individualized deep brain stimulation: A stereoelectroencephalography-based workflow for neurostimulation target identification

Saxiphilin functions as a “toxin sponge” protein that counteracts the effects of saxitoxin poisoning

Kavli Affiliate: Daniel Minor | Authors: Samantha A Nixon, Sandra Zakrzewska, Seil Jang, Keli Huang, Anissa Bara, Zhou Chen, Daynen R Goss, Elizabeth Park, J Du Bois and Daniel L Minor, Jr. | Summary: Saxitoxin (STX) is among the most potent toxins known, is classified as a chemical weapon, and is the archetype of the […]


Continue.. Saxiphilin functions as a “toxin sponge” protein that counteracts the effects of saxitoxin poisoning

Need-selective gating of dopamine neuron cue responses by real and virtual hunger

Kavli Affiliate: Anatol Kreitzer, Joshua Berk and Zachary Knight | Authors: Aphroditi A Mamaligas, Joshua Berke, Anatol C Kreitzer and Zachary A Knight | Summary: The midbrain dopamine system is important for linking reward-predictive cues to learning and 20 motivation. Here we investigated how dopamine neuron responses to food and water cues are modulated by […]


Continue.. Need-selective gating of dopamine neuron cue responses by real and virtual hunger

Interrogating the Regulatory Function of HAQERs during Human Cortical Development

Kavli Affiliate: Alex Pollen | Authors: Yashodara Abeykoon, Natalie Dzikowski, Yanting Luo, Enakshi Sinniah, Seth Weaver, Bryan J Pavlovic, Jenelle L Wallace, Riley J Mangan, Craig B Lowe and Alex Aaron Pollen | Summary: Background Sequence divergence within gene regulatory elements has been proposed to play an important role in the evolution of human-specific traits, […]


Continue.. Interrogating the Regulatory Function of HAQERs during Human Cortical Development

Non-visual light modulates behavioral memory and gene expression in C. elegans

Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]


Continue.. Non-visual light modulates behavioral memory and gene expression in C. elegans

Mechanistic and Antigenic Boundaries of Henipavirus and Parahenipavirus Glycoproteins

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Robert Edwards | Authors: Aaron J May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Moumita Dutta, Maggie Barr, Rob Parks, Xiaozhi Lu, Madison Berry, Amanda Newman, Xiao Huang, Arpita Mrigwani, Kijun Song, Victor Ilevbare, Salam Sammour, Chan Soo Park, […]


Continue.. Mechanistic and Antigenic Boundaries of Henipavirus and Parahenipavirus Glycoproteins

A lateralized pathway for associating nutrients with flavors

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Zachary Knight | Authors: James C.R. Grove, Anna M Hakimi, Queenie Li, Jingkun Zhang, Heiko Backes, Bojana Kuzmanovic, Jaewon Choi, Violeta Ubadiah, Longhui Qiu, Zhengya Liu, Dana M. Small, Marc Tittgemeyer and Zachary A Knight | Summary: Animals learn about […]


Continue.. A lateralized pathway for associating nutrients with flavors