Kavli Affiliate: Seth Shipman | Authors: Jihoon Han and Seth Shipman | Summary: Here, we introduce Detectrons, modular biosensors that couples programmable toehold switches with retron-mediated reverse transcription to transduce RNA inputs into unique DNA barcodes. The ability to convert dynamic RNA signals into durable DNA records within living cells unlocks powerful new modes of […]
Kavli Affiliate: Karunesh Ganguly | Authors: Ian S Heimbuch, Preeya Khanna, Lisa Novik, Robert J Morecraft and Karunesh Ganguly | Summary: Although somatosensation is known to be important for precise hand control, how coordinated activity across sensory and motor cortical areas supports hand movements and object interactions is unclear. We simultaneously recorded neural activity from […]
Kavli Affiliate: Robert Edwards | Authors: Jacob Insua-Rodríguez, Pascal Naef, Hannah Savage, Isam Adam, Sung Kook Chun, Axel A Almet, Gautham Prabhakar, Sharon Kwon, Cassandra G Sweet, Sevilla Farah Hennessey, Angela Lincy Prem Antony Samy, Hamad Alshetaiwi, Maren Pein, Sharmila Mallya, Delia F Tifrea, Declan M Edwards, Angela Gomez-Arboledas, Zander Esh, Carina Sandoval, Katrina Taylor […]
Kavli Affiliate: Yifan Cheng | Authors: Marcell Zimanyi, Monica Dayao, Andoni I Asencor, Sravani Kondapavulur, James Asaki, Krista McCutcheon, Cristina Dabaco, Aaron Bodansky, Charles Craik, Samuel Pleasure, Joseph L DeRisi, Yifan Cheng, Michael Wilson and John V Pluvinage | Summary: Despite rapid progress in the diagnosis of autoantibody-mediated neurologic diseases, standard-of-care therapeutic options remain limited […]
Kavli Affiliate: Robert Edwards | Authors: Matthew Clark, Hui Li, Mitchell Martin, Tyler Evangelous, Sophie Gobeil, Madison Berry, Kshitij Wagh, Elena Giorgi, Michael Hogarty, Chengyan Zhao, Shuyi Wang, Lorie Marchitto, Wenge Ding, Younghoon Park, Juliette Rando, John Carey, Andrew Connell, Ashwin Skelly, Yue Chen, Seth Rohr, Chuancang Jiang, Sravani Venkatayogi, Katayoun Mansouri, Robert J. Edwards, […]
Kavli Affiliate: Yifan Cheng | Authors: Huida Duan, Junxing Chen, Felicia Fianu, Wei Sun and Yifan Cheng | Summary: Under acidic conditions, polycationic polymer coatings function as protective immobilization supports through protonation-mediated local pH buffering. However, it remains unclear how polymer support design parameters, such as film thickness and charge density, govern that vital protonation […]
Kavli Affiliate: Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Samuel R Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Emrey Broyles, Donghoon Shin, Sharon Chiang, Cristofer Holobetz, Andrew Tritt, […]
Kavli Affiliate: Robert Edwards | Authors: Daniel William Thorpe, Yoichiro Ootsuka, Rochelle A Peterson, Lauren A Jones, Adam Humenick, Alyce M Martin, Jett Zivkovic, Junichi Sakaguchi, Jack McArdle, Arne Ittner, Simon J Brookes, Ali Habib, Rata Sirimaharaj, Youssef Tawodros, Michael J. Roach, Robert A Edwards, Hans Clevers, Joep Beumer, Jens Puschof, Lai Wei, Rajan Singh, […]
Kavli Affiliate: Wei Min | Authors: Beimin Liu, Chao Wang, Qingyang Zeng, Min Wei, Weilai Lu, Xueyan Gao, Jing Wan, Jie Feng and Yu Vincent Fu | Summary: Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) poses a severe global health threat. Phage therapy is a promising alternative, but requires precise matching of phage to the bacterial strain. […]
Kavli Affiliate: Hana El-Samad | Authors: Erik J. Navarro, William Poole, Ariane Lismer, Jieqiong Qu, Ioannis Kafetzopoulos, Aled Parry, Jannat Ijaz, Alice Santambrogio, Ryan Spangler, Francisco M. Martin-Zamora, Ken Raj, Wolf Reik, Hana El-Samad, Carlos F. Lopez and Simone Bianco | Summary: In multi-cellular eukaryotic organisms, cell type and specific functional identity are defined by […]