Kavli Affiliate: Yifan Cheng | Authors: Hayden S Saunders, Un Seng Chio, Camille M Moore, Vijay Ramani, Yifan Cheng and Geeta Narlikar | Summary: Summary: The essential architectural protein HMGB1 increases accessibility of nucleosomal DNA and counteracts the effects of linker histone H1. However, HMGB1 is less abundant than H1 and binds nucleosomes more weakly […]
Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris and Christopher Timmermann | Summary: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory […]
Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: We report the existence of a working memory system in the nematode C. elegans that is employed for deferred action in a […]
Kavli Affiliate: Kevin Bender | Authors: Ryan Alexander and Kevin Bender | Summary: Opioids regulate circuits associated with motivation and reward across the brain. Of the opioid receptor types, delta opioid receptors (DORs) appear to have a unique role in regulating the activity of circuits related to reward without a liability for abuse. In neocortex, […]
Kavli Affiliate: Xin Duan | Authors: Julieta Gomez-Frittelli, Gabrielle Frederique Devienne, Lee Travis, Melinda A Kyloh, Xin Duan, Tim J Hibberd, Nick J Spencer, John R Huguenard and Julia Kaltschmidt | Summary: Intrinsic sensory neurons are an essential part of the enteric nervous system (ENS) and play a crucial role in gastrointestinal tract motility and […]
Kavli Affiliate: Xin Duan | Authors: Travis D Goode, Jason Bondoc Alipio, Antoine Besnard, Devesh Pathak, Michael Kritzer-Cheren, Ain Chung, Xin Duan and Amar Sahay | Summary: Adaptive regulation of feeding depends on linkage of internal states and food outcomes with contextual cues. Human brain imaging has identified dysregulation of a hippocampal-lateral hypothalamic area (LHA) […]
Kavli Affiliate: Alex Pollen | Authors: Emily K Corrigan, Michael DeBerardine, Aunoy Poddar, Miguel Turrero Garcia, Matthew T Schmitz, Corey Harwell, Mercedes Paredes, Fenna M Krienen and Alex Aaron Pollen | Summary: Mammalian brains vary in size, structure, and function, but the extent to which evolutionarily novel cell types contribute to this variation remains unresolved1–4. […]
Kavli Affiliate: Arturo Alvarez-Buylla Arnold R. Kriegstein Xin Duan | Authors: Li Wang, Cheng Wang, Juan A. Moriano, Songcang Chen, Guolong Zuo, Arantxa Cebrian-Silla, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Mengyi Song, Lilian G. de Oliveira, Qiuli Bi, Jonathan J. Augustin, Xinxin Ge, Mercedes F. Paredes, Eric J. Huang, Arturo Alvarez-Buylla, Xin Duan, Jingjing Li […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Sajad Hamid Ahanger, Chujing Zhang, Evan R. Semenza, Eugene Gil, Mitchel A. Cole, Li Wang, Arnold R. Kriegstein and Daniel Lim | Summary: The nuclear genome is spatially organized into a three-dimensional (3D) architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina […]
Kavli Affiliate: Jeremy Willsey | Authors: Nia Teerikorpi, Micaela C Lasser, Sheng Wang, Elina Kostyanovskaya, Ethel Bader, Nawei Sun, Jeanselle Dea, Tomasz J. Nowakowski, A Jeremy Willsey and Helen Willsey | Summary: Autism spectrum disorder (ASD) commonly co-occurs with congenital heart disease (CHD), but the molecular mechanisms underlying this comorbidity remain unknown. Given that children […]