Kavli Affiliate: Su Guo | Authors: Chee San Tong, Maohan Su, He Sun, Xiang Le Chua, Su Guo, Ravinraj S/O Ramaraj, Ann Gie Lee, Nicole Wen Pei Ong, Yansong Miao and Min Wu | Summary: The coordination between actin and microtubule network is crucial, yet our understanding of the underlying mechanisms remains limited. In this […]
Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Santiago C Lopez, Matias Rojas-Montero, Chloe B Fishman and Seth L Shipman | Summary: Our understanding of genomics is limited by the scale of our genomic technologies. While libraries of genomic manipulations scaffolded on CRISPR gRNAs have been transformative, these existing approaches are typically multiplexed across genomes. […]
Kavli Affiliate: Andrea Hasenstaub | Authors: David A. McCormick, Yousheng Shu and Andrea R Hasenstaub | Summary: A fundamental feature of the cerebral cortex is the ability to rapidly turn on and off maintained activity within ensembles of neurons through recurrent excitation balanced by inhibition. Here we demonstrate that reduction of the h-current, which is […]
Kavli Affiliate: Kristofer Bouchard, Loren Frank, Christoph Kirst | Authors: Pratik Sachdeva, Ji Hyun Bak, Jesse A Livezey, Loren Frank, Christoph Kirst, Sharmodeep Bhattacharyya and Kristofer Bouchard | Summary: In the brain, all neurons are driven by the activity of other neurons, some of which maybe simultaneously recorded, but most are not. As such, models […]
Kavli Affiliate: Jeanne Paz | Authors: Virginie Loison, Yuliya Voskobiynyk, Britta Lindquist, Deanna Necula, Dan Longrois, Jeanne T. Paz and David Holcman | Summary: Cortical electro-encephalography (EEG) has become the clinical reference for monitoring unconsciousness during general anesthesia. The current EEG-based monitors classify general anesthesia states simply as underdosed, adequate, or overdosed, with no transition […]
Kavli Affiliate: John Rubenstein | Authors: Rinaldo Catta-Preta, Susan Lindtner, Athena Ypsilanti, James Price, Armen Abnousi, Linda Su-Feher, Yurong Wang, Ivan Juric, Ian Jones, Jennifer Akiyama, Ming Hu, Yin Shen, Axel Visel, Len Pennacchio, Diane Dickel, John Rubenstein and Alex Nord | Summary: Transcription factors (TFs) bind combinatorially to genomic cis-regulatory elements (cREs), orchestrating transcription […]
Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Andra M Rudzite, Mahmood S Hoseini, Mishek Thapa, Michael P Stryker, Greg D Field and Steven W Zucker | Summary: The retina and primary visual cortex (V1) both exhibit diverse neural populations sensitive to diverse visual features. Yet it remains unclear how neural populations in each area […]
Kavli Affiliate: Philip Starr | Authors: Md Fahim Anjum, Clay Smyth, Derk-Jan Dijk, Philip Starr, Timothy Denison and Simon Little | Summary: Background: Sleep disturbance is a prevalent and highly disabling comorbidity in individuals with Parkinson’s disease (PD) that leads to worsening of daytime symptoms, accelerated disease progression and reduced quality of life. Objectives: We […]
Kavli Affiliate: Michael Stryker | Authors: Megumi Kaneko, Mahmood S Hoseini, James A Waschek and Michael P Stryker | Summary: When adult mice are repeatedly exposed to a particular visual stimulus for as little as one hour per day for several days while their visual cortex (V1) is in the high-gain state produced by locomotion, […]
Kavli Affiliate: Yifan Cheng | Authors: Un Seng Chio, Eugene Palovcak, Anton A. A. Autzen, Henriette E. Autzen, Elise N. Munoz, Zanlin Yu, Feng Wang, David A. Agard, Jean-Paul Armache, Geeta Narlikar and Yifan Cheng | Summary: Single-particle cryo-EM is widely used to determine enzyme-nucleosome complex structures. However, cryo-EM sample preparation remains challenging and inconsistent […]