Spyglass: a data analysis framework for reproducible and shareable neuroscience research

Kavli Affiliate: Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Samuel R Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Emrey Broyles, Donghoon Shin, Sharon Chiang, Cristofer Holobetz, Andrew Tritt, […]


Continue.. Spyglass: a data analysis framework for reproducible and shareable neuroscience research

The mood stabilizer lithium alters behaviour and physiology via the gut brain axis

Kavli Affiliate: Robert Edwards | Authors: Daniel William Thorpe, Yoichiro Ootsuka, Rochelle A Peterson, Lauren A Jones, Adam Humenick, Alyce M Martin, Jett Zivkovic, Junichi Sakaguchi, Jack McArdle, Arne Ittner, Simon J Brookes, Ali Habib, Rata Sirimaharaj, Youssef Tawodros, Michael J. Roach, Robert A Edwards, Hans Clevers, Joep Beumer, Jens Puschof, Lai Wei, Rajan Singh, […]


Continue.. The mood stabilizer lithium alters behaviour and physiology via the gut brain axis

Single-Cell Raman Profiling Enables Rapid Precision Phage Therapy Against Multidrug-Resistant Hypervirulent Klebsiella pneumoniae

Kavli Affiliate: Wei Min | Authors: Beimin Liu, Chao Wang, Qingyang Zeng, Min Wei, Weilai Lu, Xueyan Gao, Jing Wan, Jie Feng and Yu Vincent Fu | Summary: Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) poses a severe global health threat. Phage therapy is a promising alternative, but requires precise matching of phage to the bacterial strain. […]


Continue.. Single-Cell Raman Profiling Enables Rapid Precision Phage Therapy Against Multidrug-Resistant Hypervirulent Klebsiella pneumoniae

A Physics-based Model Reveals Mechanisms of Epigenetic Memory

Kavli Affiliate: Hana El-Samad | Authors: Erik J. Navarro, William Poole, Ariane Lismer, Jieqiong Qu, Ioannis Kafetzopoulos, Aled Parry, Jannat Ijaz, Alice Santambrogio, Ryan Spangler, Francisco M. Martin-Zamora, Ken Raj, Wolf Reik, Hana El-Samad, Carlos F. Lopez and Simone Bianco | Summary: In multi-cellular eukaryotic organisms, cell type and specific functional identity are defined by […]


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Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: The global rise in human […]


Continue.. Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

NPEPPS segmental duplication drives position effect expression of TBC1D3 in the human brain

Kavli Affiliate: Alex Pollen | Authors: Xavi Guitart, Jessie W. Brunner, Luyao Ren, Hyeonsoo Jeong, DongAhn Yoo, David Porubsky, Mitchell R. Vollger, Kendra Hoekzema, Katherine M. Munson, Kaitlyn Sun, Marcelo Ayllon, Kaylynn Hoglin, Reed McMullen, Bryan Pavlovic, Alex Aaron Pollen and Evan E Eichler | Summary: In humans, the TBC1D3 gene family is thought to […]


Continue.. NPEPPS segmental duplication drives position effect expression of TBC1D3 in the human brain

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

Kavli Affiliate: Jeanne Paz | Authors: Hayk Davtyan, Sarah Naguib, Yuliya Voskobiynyk, Jean Paul Chadarevian, Joia K. Capocchi, Jeannie L. Giacchino, Ghazaleh Eskandari-Sedighi, Vivianna Denittis, Jeremy Ford, Ani Agababian, Jasmine Nguyen, Alina Chadarevian, Madison Sutherland, Sepideh Kiani Shabestari, Alissa Nanali, Jiasheng Zhang, Salvatore Spina, Man Ying Wong, Lea Tenenholz Grinberg, William W Seeley, Eric Huang, […]


Continue.. Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

Scalable high-fidelity human vascularized cortical assembloids recapitulate neurovascular co-development and cell specialization

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Arnold R. Kriegstein and Edward Chang | Authors: Shubhang Bhalla, Belda Gulsuyu, Damian Sanchez, Jayden M Ross, Santhosh Arul, Adnan Gopinadhan, Muhammet Ozturk, Tanzila Mukhtar, Jonathan J Augustin, Jerry C Wang, Joseph Kim, Chang N Kim, Sena Oten, Yohei Rosen, […]


Continue.. Scalable high-fidelity human vascularized cortical assembloids recapitulate neurovascular co-development and cell specialization

A genetically encoded reporter reveals interferon responses in multiple cell lineages

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Anna Molofsky | Authors: Sarah R Anderson, Pailin Chiaranunt, Nicholas M Mroz, Sarah D Wade, Ari B Molofsky and Anna V Molofsky | Summary: Interferons (IFNs) are canonical antiviral cytokines with emerging homeostatic functions across tissues, including in the brain. […]


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An orthogonal TRAP enables intersectional genetic access to activated neurons in the mouse brain

Kavli Affiliate: Zachary Knight | Authors: Nikolaos Chatziris, Brooke C Jarvie, Can Liu and Zachary A Knight | Summary: The study of neural circuits has been greatly enabled by methods for obtaining genetic access to activated neurons. However, these approaches typically tag neurons based on their response to only a single stimulus, which limits the […]


Continue.. An orthogonal TRAP enables intersectional genetic access to activated neurons in the mouse brain