Kavli Affiliate: Alex Pollen | Authors: Alyssa M Yoxsimer, Rhea R Daugherty, Emily E Hare, Yingguang Frank Chan, Felicity C Jones, Garrett A Roberts Kingman, Emma G Offenberg, Timothy R Howes, Haili Zhang, Alex Aaron Pollen, Shannon D Brady, Kathleen T Xie, Heidi I Chen, Craig B Lowe, Eric H Au, Jane Grimwood, Jeremy Schmutz, […]
Kavli Affiliate: Daniel Minor | Authors: Sandra Zakrzewska, Zhou Chen, Elizabeth Park, Roshni G Bhaskar, T. Aaron Bedell, J Du Bois and Daniel L Minor, Jr. | Summary: Saxitoxin (STX) and its congeners (paralytic shellfish toxins, PSTs) are among the most potent small-molecule toxins. PSTs are produced by harmful algal blooms and derive toxicity by […]
Kavli Affiliate: Adam Gazzaley | Authors: Andrew C Heusser, Tony J Simon, Esther Elliot, Christopher James, Adam Gazzaley and Nicole Gibson | Summary: Background Emotion regulation—the ability to respond to and restore equilibrium after emotional perturbations—is central to mental health. Yet objective measurement remains limited to lab-based studies with group-level results, while consumer wearables focus […]
Kavli Affiliate: Mazen Kheirbek | Authors: Joshua X Bratsch-Prince, Mingyang Wei, Srutika Sureshbabu, Vivan Chhaya, Nuria Cano Adamuz, Kelsey Logas and Mazen Kheirbek | Summary: In uncertain, threatening environments, rapid and flexible behavioral decisions are essential for survival. The ventral CA1 region of the hippocampus encodes threatening contexts and can regulate avoidance-related behaviors. While activity […]
Kavli Affiliate: Roger Nicoll | Authors: tianli dou, junting zhang, yidan hong, xiumin chen and roger nicoll | Summary: Excitatory glutamatergic synapses in the brain are remarkably plastic. Two forms of plasticity have received the most attention: long-term potentiation (LTP) and synaptic homeostasis. While LTP requires the activation of NMDA receptors, synaptic homeostasis does not. […]
Kavli Affiliate: Zachary Knight | Authors: Truong Ly, Xinyang Yi, Grace R. Lee, James CR Grove, Youssef E. Sibih, Yun Y. Oh, Longhui Qiu, Nilla Sivakumar and Zachary A Knight | Summary: The termination of a meal is triggered by sensory feedback from the stomach and intestines that reports on ingested food1–10 and is relayed […]
Kavli Affiliate: Seth Shipman | Authors: Jihoon Han and Seth Shipman | Summary: Here, we introduce Detectrons, modular biosensors that couples programmable toehold switches with retron-mediated reverse transcription to transduce RNA inputs into unique DNA barcodes. The ability to convert dynamic RNA signals into durable DNA records within living cells unlocks powerful new modes of […]
Kavli Affiliate: Karunesh Ganguly | Authors: Ian S Heimbuch, Preeya Khanna, Lisa Novik, Robert J Morecraft and Karunesh Ganguly | Summary: Although somatosensation is known to be important for precise hand control, how coordinated activity across sensory and motor cortical areas supports hand movements and object interactions is unclear. We simultaneously recorded neural activity from […]
Kavli Affiliate: Robert Edwards | Authors: Jacob Insua-Rodríguez, Pascal Naef, Hannah Savage, Isam Adam, Sung Kook Chun, Axel A Almet, Gautham Prabhakar, Sharon Kwon, Cassandra G Sweet, Sevilla Farah Hennessey, Angela Lincy Prem Antony Samy, Hamad Alshetaiwi, Maren Pein, Sharmila Mallya, Delia F Tifrea, Declan M Edwards, Angela Gomez-Arboledas, Zander Esh, Carina Sandoval, Katrina Taylor […]
Kavli Affiliate: Yifan Cheng | Authors: Marcell Zimanyi, Monica Dayao, Andoni I Asencor, Sravani Kondapavulur, James Asaki, Krista McCutcheon, Cristina Dabaco, Aaron Bodansky, Charles Craik, Samuel Pleasure, Joseph L DeRisi, Yifan Cheng, Michael Wilson and John V Pluvinage | Summary: Despite rapid progress in the diagnosis of autoantibody-mediated neurologic diseases, standard-of-care therapeutic options remain limited […]