Kavli Affiliate: Mark H. Tuszynski; | Authors: Pabitra K Sahoo, Nick Hanovice, Patricia Ward, Manasi A Agrawal, Terika P Smith, HaoMin SiMa, Jennifer N Dulin, Lauren S Vaughn, Mark Tuszynski, Kristy Welshhans, Larry Benowitz, Arthur English, John D Houle and Jeffery L Twiss | Summary: Depletion or inhibition of core stress granule proteins, G3BP1 in […]
Kavli Affiliate: Mark Ellisman; | Authors: Aaron T Kuan, Sebastien Phan, Keun-Young Kim, Mason Mackey, Minsu Kim, Steven T Peltier, Mark Ellisman and Wei-Chung Allen Lee | Summary: We demonstrate limited-tilt, serial section electron tomography (ET), which can non-destructively map brain circuits over large 3D volumes and reveal high-resolution, supramolecular details within subvolumes of interest. […]
Kavli Affiliate: Stephan Anagnostaras; | Authors: Joseph Offenberger, Bianca Chen, Leigh-Ana Rossitto, Irisa Jin, Liam Conaboy, Helios Gallego-Gutierrez, Bliss Nelsen, Eduardo Frias-Anaya, David J. Gonzalez, Stephan Anagnostaras and Miguel Alejandro Lopez-Ramirez | Summary: Background Cerebral Cavernous Malformations (CCMs) are neurovascular abnormalities in the central nervous system (CNS) caused by loss of function mutations in KRIT1 […]
Kavli Affiliate: Sreekanth Chalasani | Authors: Kathleen T Quach, Gillian A Hughes and Sreekanth H Chalasani | Summary: Prey must balance the need to avoid predators with the need to feed, a dilemma central to prey refuge theory. Additionally, prey must also assess predatory imminence, or how close predator threats are in space and time. […]
Kavli Affiliate: Timothy Brown | Authors: Fadi Jradi, Brian P English, Timothy A Brown, Jesse Arron, Satya Khuon, James A Galbraith, Catherine G Galbraith and Luke D Lavis | Summary: Single-molecule localization microscopy (SMLM) uses activatable or switchable fluorophores to create non-diffraction limited maps of molecular location in biological samples. Despite the utility of this […]
Kavli Affiliate: Anders Dale | Authors: Diana M. Smith, Pravesh Parekh, Joseph Kennedy, Robert J. Loughnan, Oleksandr Frei, Thomas E. Nichols, Ole A. Andreassen, Terry L. Jernigan and Anders M. Dale | Summary: The relative contributions of genetic variation and experience in shaping the morphology of the adolescent brain are not fully understood. Using longitudinal […]
Kavli Affiliate: Kay Tye | Authors: Alexander Lin, Cyril Akafia, Olga Dal Monte, Siqi Fan, Nicholas Fagan, Philip Putnam, Kay M. Tye, Steve Chang, Demba Ba and AZA Stephen Allsop; | Summary: In neuroscience, understanding how single-neuron firing contributes to distributed neural ensembles is crucial. Traditional methods of analysis have been limited to descriptions of […]
Kavli Affiliate: Yishi Jin | Authors: Seungmee Park, Nathaniel Noblett, Lauren Pitts, Antonio Colavita, Ann M Wehman, Yishi Jin and Andrew D Chishol/p> | Summary: Mature neurons maintain their distinctive morphology for extended periods in adult life. Compared to developmental neurite outgrowth, axon guidance, and target selection, relatively little is known of mechanisms that maintain […]
Kavli Affiliate: Marcelo Mattar | Authors: Kristopher T. Jensen, Guillaume Hennequin and Marcelo G. Mattar | Summary: When interacting with complex environments, humans can rapidly adapt their behavior to changes in task or context. To facilitate this adaptation, we often spend substantial periods of time contemplating possible futures before acting. For such planning to be […]
Kavli Affiliate: Yishi Jin | Authors: Dana T Byrd, Ziyuan Christina Han, Christopher A Piggott and Yishi Jin | Summary: PACS (Phosphofurin Acidic Cluster Sorting Protein) proteins are known for their roles in sorting cargo proteins to organelles and can physically interact with WD40 repeat-containing protein WDR37. PACS1, PACS2, and WDR37 variants are associated with […]