Kavli Affiliate: Yishi Jin | Authors: Yishi Jin, Stephan M Blazie, Daniel Fortunati and Yan Zhao | Summary: Protein translation initiation is a complex and conserved process involving many proteins acting in concert. The eukaryotic initiation factor 3 (eIF3) complex is essential for the assembly of the pre-initiation complex that scans and positions mRNA at […]
Kavli Affiliate: Sreekanth Chalasani | Authors: Nadia B Haghani, Robert H Lampe, Buck Samuel, Sreekanth H Chalasani and Molly A Matty | Summary: In the wild, C. elegans are emersed in environments teeming with a veritable menagerie of microorganisms. The C. elegans cuticular surface serves as a barrier and first point of contact with this […]
Kavli Affiliate: Mark Ellisman | Authors: Yi Sak Kim, SOO-HO CHOI, Keun-Young Kim, Juliana M Navia Pelaez, Guy A Perkins, Seunghwan Choi, Nicolaus Nazarenkov Miller, Jungsu Kim, Wonkyu Ju, Robert A Rissman, Mark H Ellisman and Yury I Miller | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia […]
Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang, Mia Cameron and Terrence J Sejnowski | Summary: The hippocampus receives sequences of sensory inputs from the cortex during exploration and encodes the sequences with millisecond precision. We developed a predictive autoencoder model of the hippocampus including the trisynaptic and monosynaptic circuits from the entorhinal […]
Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B. Kennedy | Summary: Activation of N-methyl-D-aspartate-type glutamate receptors (NMDARs) at synapses in the CNS triggers changes in synaptic strength that underlie memory formation in response to strong synaptic stimuli. The primary target of Ca2+ flowing through […]
Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Abstract Everyday perceptual tasks require sensory stimuli to be dynamically encoded and analyzed according to changing behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating […]
Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, Beth Friedman, Jun Takatoh, Fan Wang, David Kleinfeld and Yoav Freund | Summary: One of the important yet labor intensive tasks in neuroanatomy is the identification of select populations of cells. Current high-throughput techniques enable marking cells with histochemical fluorescent molecules as well as through the genetic […]
Kavli Affiliate: John Reynolds | Authors: Tom P. Franken and John H. Reynolds | Summary: Our perception of how objects are laid out in visual scenes is remarkably stable, despite rapid shifts in the patterns of light that fall on the retina with each saccade. One mechanism that may help establish perceptual stability is border […]
Kavli Affiliate: Anders Dale | Authors: Atle Eskeland Rimehaug, Anders M. Dale, Anton Arkhipov and Gaute T. Einevoll | Summary: The local field potential (LFP), the low-frequency part of the extracellular potential, reflects transmembrane currents in the vicinity of the recording electrode. Thought mainly to stem from currents caused by synaptic input, it provides information […]
Kavli Affiliate: Terrence Sejnowski | Authors: Dana E Cobb-Lewis, Anne George, Shannon Hu, Katherine Packard, Mingyuan Song, Oliver Nguyen-Lopez, Emily Ikematsu Tesone, Jhanay Rowden, Julie Wang and Maya Opendak | Summary: Long-term potentiation (LTP) has become a standard model for investigating synaptic mechanisms of learning and memory. Increasingly, it is of interest to understand how […]