Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Kay Tye | Authors: Austin Coley, Kanha Batra, Jeremy Delahanty, Laurel Keyes, Rachelle Pamintuan, Assaf Ramot, Jim Hagemann, Christopher Lee, Vivian Liu, Harini Adivikolanu, Jianna Cressy, Caroline Jia, Francesca Massa, Deryn LeDuke, Moumen Gabir, Braa Durubeh, Lexe linderhof, Reesha Patel, […]


Continue.. Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression

Parsing auditory neural code into maximum-entropy packets

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Tatyana Sharpee | Authors: Huanqiu Zhang, Israel Nelken and Tatyana Sharpee | Summary: Deciphering the neural code requires identifying its fundamental symbols or code-words. Neural activity is usually interpreted either as a rate code – based on average spike counts […]


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A switch in arousal circuit architecture shapes sleep across the lifespan

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Kenta Asahina | Authors: Milan Szuperak, Mareike S Selcho, Katharina Eichler, Patrick D McClanahan, Kenta Asahina, Jeffrey Rosa, Christopher Fang-Yen, Andreas S Thum and Matthew S Kayser | Summary: Sleep is a continuous behavior across the lifespan, yet its features […]


Continue.. A switch in arousal circuit architecture shapes sleep across the lifespan

Human Strategy Adaptation in Reinforcement Learning Resembles Policy Gradient Ascent

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Marcelo Mattar | Authors: Hua-Dong Xiong, Li Ji-An, Robert C Wilson and Marcelo G Mattar | Summary: A hallmark of intelligence is the ability to adapt behavior to changing environments, which requires adapting one’s own learning strategies. This phenomenon is […]


Continue.. Human Strategy Adaptation in Reinforcement Learning Resembles Policy Gradient Ascent

Shared Molecular Landscape of Human Brain Structure and Systemic Metabolism

Kavli Affiliate: Anders Dal | Authors: Dennis van der Meer, Jakub Kopal, Sara Stinson, Olav Smeland, Alexey Shadrin, Julian Fuhrer, Jaroslav Rokicki, Tiril Gurholt, Ida Sonderby, Ibrahim Akkouh, Oleksandr Frei, Kevin O’Connell, Lars T. Westlye, Srdjan Djurovic, Anders Dale and Ole Andreassen | Summary: The human brain is metabolically demanding, yet the causal interplay between […]


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Developmental variation in dopamine neurobiology, neurocognitive functioning, and impulsivity shape substance use trajectories in youth

Kavli Affiliate: Wesley Thompson | Authors: Ashley Clare Parr, Amar Ojha, Daniel Petrie, Finnegan Calabro, Brenden Tervo-Clemmens, Will Foran, Douglas Fitzgerald, Susan Tapert, Kate Nooner, Wesley Thompson, David Goldston, Duncan Clark and Beatriz Luna | Summary: Theoretical neurodevelopmental models implicate increases in dopamine (DA) function and limitations in neurocognitive control in risk-taking behavior, including substance […]


Continue.. Developmental variation in dopamine neurobiology, neurocognitive functioning, and impulsivity shape substance use trajectories in youth

Memory recall errors reflect interacting sensory and mnemonic representations

Kavli Affiliate: John Serences | Authors: Holly Kular and John Serences | Summary: Visual working memory (WM) enables the maintenance of information that is no longer present in the environment. Some accounts propose that WM is supported by abstract representations so that new sensory inputs do not interfere with existing memories. Others posit that early […]


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A genetically-defined population of amygdalofugal neurons promotes suckling and early postnatal growth

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Samuel Pfaff | Authors: Jeffrey Moore, Lukas Bachmann, Lauren McElvain, Samuel Pfaff and Catherine Dulac | Summary: Suckling by newborns is an instinctive behavior defining the mammalian class. Yet, due to experimental difficulty in assessing neural function in the very […]


Continue.. A genetically-defined population of amygdalofugal neurons promotes suckling and early postnatal growth

Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Angela Yu | Authors: Samantha E. Koplik, Angela M Yu, Madelyn R. Shelby, Gabriel C. Fonseca, Charles M. Roco, Yue Zhang, Nicholas Bogard, Alex K. Sabo, Alexander B. Rosenberg, Johannes Linder and Georg Seelig | Summary: Splice-disrupting variants (SDVs) underlie […]


Continue.. Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation

Astrocyte SEMA3C reduction improves Rett Syndrome phenotypes

Kavli Affiliate: Nicola Allen | Authors: Krissy A Lyon, Adrien Paumier, Ananya Kandikonda, Andrea Melendez and Nicola J Allen | Summary: During typical neurodevelopment, astrocytes secrete proteins that support neuronal connectivity. This process is disrupted in Rett Syndrome (RTT), a regressive neurodevelopmental disorder characterized by motor, sensory, and cognitive impairments. While astrocytes typically promote neuron […]


Continue.. Astrocyte SEMA3C reduction improves Rett Syndrome phenotypes