Spatiotemporal development of growth and death zones in expanding bacterial colonies driven by emergent nutrient dynamics

Kavli Affiliate: David Kleinfeld | Authors: Harish Kannan, Paul Sun, Tolga Çağlar, Pantong Yao, Brian R Taylor, Kinshuk Sahu, Daotong Ge, Matteo Mori, Mya Warren, David Kleinfeld, JiaJia Dong, Bo Li and Terence Hwa | Summary: Bacterial colony growth on hard agar is commonplace in microbiology; yet, what occurs inside a growing colony is complex […]


Continue.. Spatiotemporal development of growth and death zones in expanding bacterial colonies driven by emergent nutrient dynamics

Beyond Lux: Methods for Species and Photoreceptor-Specific Quantification of Ambient Light for Mammals

Kavli Affiliate: Timothy Brown | Authors: Richard J McDowell, Altug Didikoglu, Tom Woelders, Mazie J Gatt, Roelof A. Hut, Timothy M Brown and Robert J Lucas | Summary: Background Light is a key environmental regulator of physiology and behaviour. Mistimed or insufficient light disrupts circadian rhythms and is associated with impaired health and well-being across […]


Continue.. Beyond Lux: Methods for Species and Photoreceptor-Specific Quantification of Ambient Light for Mammals

Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.

Kavli Affiliate: Mark Ellisman | Authors: Cristiane dos Santos, Shristi Shrestha, Matthew A Cottam, Guy Perkins, Varda Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Melanie Cutler, Danielle Dean, Jean Philippe Cartailler, Patrick E MacDonald, Martin W Hetzer, Mark H Ellisman and Rafael Arrojo e Drigo | Summary: Caloric restriction (CR) extends organismal lifespan […]


Continue.. Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Kavli Affiliate: Anders Dale | Authors: Elleke Tissink, Alexey A Shadrin, Dennis van der Meer, Nadine Parker, Guy Hindley, Daniel Roelfs, Oleksandr Frei, Chun Chieh Fan, Mats Nagel, Terje Naerland, Magdalena Budisteanu, Srdjan Djurovic, Lars T. Westlye, Martijn van den Heuvel, Danielle Posthuma, Tobias Kaufmann, Anders M. Dale and Ole Andreassen | Summary: Genetic pleiotropy […]


Continue.. Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Estimating the Total Variance Explained by Whole-Brain Imaging for Zero-inflated Outcomes

Kavli Affiliate: Wesley Thompson | Authors: Junting Ren, Robert John Loughnan, Bohan Xu, Wesley K. Thompson and Chun Chieh Fan | Summary: Zero-inflated outcomes are very common in behavioral data, particularly for responses to psychological questionnaires. Modeling these challenging distributions is further exacerbated by the absence of established statistical models capable of characterizing total signals […]


Continue.. Estimating the Total Variance Explained by Whole-Brain Imaging for Zero-inflated Outcomes

Gene editing in the Chagas disease vector Rhodnius prolixus by Cas9-mediated ReMOT Control

Kavli Affiliate: Ethan Bier | Authors: Leonardo Lima, Mateus Berni, Jamile Mota, Daniel Bressan, Alison Julio, Robson Cavalcante, Vanessa Macias, Zhiqian Li, Jason L. Rasgon, Ethan Bier and Helena Marcolla Araujo | Summary: Rhodnius prolixus is currently the model vector of choice for studying Chagas disease transmission, a debilitating disease caused by Trypanosoma cruzi parasites. […]


Continue.. Gene editing in the Chagas disease vector Rhodnius prolixus by Cas9-mediated ReMOT Control

Xylem sap residue in cut-open conduits can affect gas discharge in pneumatic experiments

Kavli Affiliate: Gabriel Silva | Authors: Marcela Trevenzoli Miranda, Luciano Pereira, Gabriel Silva Pires, Xinyi Guan, Luciano Melo Silva, Swetlana Kreinert, Eduardo Caruso Machado, Steven Jansen and Rafael Ribeiro | Summary: Considerable progress has been made in understanding the mechanisms of embolism formation based on the pneumatic method, which relies on gas discharge measurements. Here, […]


Continue.. Xylem sap residue in cut-open conduits can affect gas discharge in pneumatic experiments

A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)

Kavli Affiliate: Wesley Thompson | Authors: Rong Zablocki, Bohan Xu, Chun-Chieh Fan and Wesley K. Thompson | Summary: Here we present a development of the novel Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC) model. BRAINIAC allows for both estimation of total variance explained by all features for a given cognitive phenotype, as well […]


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Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components using a large adolescent sample

Kavli Affiliate: Anders Dale | Authors: Diana M. Smith, Pravesh Parekh, Joseph Kennedy, Robert J. Loughnan, Oleksandr Frei, Thomas E. Nichols, Ole A. Andreassen, Terry L. Jernigan and Anders M. Dale | Summary: The relative contributions of genetic variation and experience in shaping the morphology of the adolescent brain are not fully understood. Using longitudinal […]


Continue.. Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components using a large adolescent sample

Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

Kavli Affiliate: Andrea Hasenstaub | Authors: David A. McCormick, Yousheng Shu and Andrea R Hasenstaub | Summary: The ventral pallidum (VP) contains GABA and glutamate (Glut) neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the cell-type-specific mechanisms by which VP projections to VTA drive […]


Continue.. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types