High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

Kavli Affiliate: Mark Ellisman | Authors: George A. Spirou, Matthew Kersting, Sean Carr, Bayan Razzaq, Carolyna Y. Alves-Pinto, Mariah Dawson, Mark H. Ellisman and Paul B. Manis | Summary: Globular bushy cells (GBCs) of the cochlear nucleus play central roles in the temporal processing of sound. Despite investigation over many decades, fundamental questions remain about […]


Continue.. High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

Domain-specific cognitive impairment reflects prefrontal dysfunction in aged common marmosets

Kavli Affiliate: John Reynolds | Authors: Courtney Glavis-Bloom, Casey R Vanderlip, Payton A Asch and John H Reynolds | Summary: Age-related cognitive impairment is not expressed uniformly across cognitive domains. Cognitive functions that rely on brain areas that undergo substantial neuroanatomical changes with age often show age-related impairment, while those that rely on brain areas […]


Continue.. Domain-specific cognitive impairment reflects prefrontal dysfunction in aged common marmosets

Reward contingency gates selective cholinergic suppression of amygdala neurons

Kavli Affiliate: Kay Tye | Authors: Eyal Y. Kimchi, Anthony Burgos-Robles, Gillian A Matthews, Tatenda Chakoma, Makenzie Patarino, Javier C Weddington, Cody A Siciliano, Wannan Yang, Shaun Foutch, Renee Simons, Ming-fai Fong, miao jing, Yulong Li, Daniel B Polley and Kay M. Tye | Summary: Basal forebrain cholinergic neurons modulate how organisms process and respond […]


Continue.. Reward contingency gates selective cholinergic suppression of amygdala neurons

Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans egg laying behavior

Kavli Affiliate: Sreekanth Chalasani | Authors: Amy Pribadi, Michael A Rieger, Kaila Rosales, Kirthi C Reddy and Sreekanth H Chalasani | Summary: Prey respond to predators by altering their behavior to optimize their own fitness and survival. Specifically, prey are known to avoid predator-occupied territories to reduce their risk of harm or injury to themselves […]


Continue.. Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans egg laying behavior

Automatic Discovery of Cognitive Strategies with Tiny Recurrent Neural Networks

Kavli Affiliate: Marcelo Mattar | Authors: Li Ji-An, Marcus K Benna and Marcelo G Mattar | Summary: Normative frameworks such as Bayesian inference and reward-based learning are useful tools for explaining the fundamental principles of adaptive behavior. However, their ability to describe realistic animal behavior is limited by the often small number of parameters that […]


Continue.. Automatic Discovery of Cognitive Strategies with Tiny Recurrent Neural Networks

Brain-wide Correspondence Between Neuronal Epigenomics and Long-Distance Projections

Kavli Affiliate: Edward Callaway | Authors: Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Angeline C. Rivkin, Will N. Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew I. Aldridge, Qiurui Zeng, J.L. Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Jordan […]


Continue.. Brain-wide Correspondence Between Neuronal Epigenomics and Long-Distance Projections

FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data

Kavli Affiliate: Wesley Thompson, Anders Dale | Authors: Pravesh Parekh, Chun Chieh Fan, Oleksandr Frei, Clare E Palmer, Diana M. Smith, Carolina Makowski, John Iverson, Diliana Pecheva, Dominic Holland, Robert Loughnan, Pierre Nedelec, Wesley K Thompson, Donald J. Hagler, Jr., Ole A. Andreassen, Terry L Jernigan, Thomas Nichols and Anders M. Dale | Summary: The […]


Continue.. FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data

TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis

Kavli Affiliate: Mark Ellisman | Authors: Sumin Kim, Sebastien Phan, Thomas R Shaw, Mark H Ellisman, Sarah L Veatch, Sami J Barmada, Samuel S Pappas and William T Dauer | Summary: Nuclear pore complexes (NPCs) regulate information transfer between the nucleus and cytoplasm. NPC defects are linked to several neurological diseases, but the processes governing […]


Continue.. TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis

The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Kavli Affiliate: Angela Yu | Authors: Liang Liu, Angela M Yu, Xiuye Wang, Lindsey V. Soles, Yiling Chen, Yoseop Yoon, Kristianna S.K. Sarkan, Marielle Cárdenas Valdez, Johannes Linder, Ivan Marazzi, Zhaoxia Yu, Feng Qiao, Wei Li, Georg Seelig and Yongsheng Shi | Summary: JTE-607 is a small molecule compound with anti-inflammation and anti-cancer activities. Upon […]


Continue.. The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery